Browsing Department of Clinical Science by Journals "European Respiratory Journal Open Research (ERJ Open Research)"
Now showing items 1-9 of 9
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Clinical characteristics, risk factors and outcomes in patients with severe COVID-19 registered in the ISARIC WHO clinical characterisation protocol: a prospective, multinational, multicentre, observational study
(Journal article; Peer reviewed, 2022)Due to the large number of patients with severe coronavirus disease 2019 (COVID-19), many were treated outside the traditional walls of the intensive care unit (ICU), and in many cases, by personnel who were not trained ... -
A genome-wide association study of bronchodilator response in participants of European and African ancestry from six independent cohorts
(Journal article; Peer reviewed, 2022)Introduction Bronchodilator response (BDR) is a measurement of acute bronchodilation in response to short-acting β2-agonists, with a heritability between 10 and 40%. Identifying genetic variants associated with BDR may ... -
Low levels of endogenous anabolic androgenic steroids in females with severe asthma taking corticosteroids
(Journal article; Peer reviewed, 2023)Rationale Patients with severe asthma are dependent upon treatment with high doses of inhaled corticosteroids (ICS) and often also oral corticosteroids (OCS). The extent of endogenous androgenic anabolic steroid (EAAS) ... -
Pharmacological treatment of asthma in a cohort of adults during a 20-year period: results from the European Community Respiratory Health Survey I, II and III
(Peer reviewed; Journal article, 2019)Asthma often remains uncontrolled, despite the fact that the pharmacological treatment has undergone large changes. We studied changes in the treatment of asthma over a 20-year period and identified factors associated with ... -
A prospective study of pulmonary outcomes and chest computed tomography in the first year after COVID-19
(Journal article; Peer reviewed, 2023)COVID-19 primarily affects the respiratory system. We aimed to evaluate how pulmonary outcomes develop after COVID-19 by assessing participants from the first pandemic wave prospectively 3 and 12 months following hospital ... -
Protected sampling is preferable in bronchoscopic studies of the airway microbiome
(Journal article; Peer reviewed, 2017)The aim was to evaluate susceptibility of oropharyngeal contamination with various bronchoscopic sampling techniques. 67 patients with obstructive lung disease and 58 control subjects underwent bronchoscopy with ... -
Reliability of maximum oxygen uptake in cardiopulmonary exercise testing with continuous laryngoscopy
(Journal article; Peer reviewed, 2020)Aims: A cardiopulmonary exercise test (CPET) is the gold standard to evaluate symptom-limiting exercise intolerance, while continuous laryngoscopy performed during exercise (CLE) is required to diagnose exercise-induced ... -
Reliability of translaryngeal airway resistance measurements during maximal exercise
(Journal article; Peer reviewed, 2022)Objective Exercise-induced laryngeal obstruction is an important cause of exertional dyspnoea. The diagnosis rests on visual judgement of relative changes of the laryngeal inlet during continuous laryngoscopy exercise (CLE) ... -
Use of inhaled ipratropium bromide to improve exercise-induced laryngeal obstruction cannot be recommended
(Journal article; Peer reviewed, 2023)Introduction: Exercise-induced laryngeal obstruction (EILO) is a common cause of exertional breathing problems in young adults. Current management generally consists of breathing advice, speech therapy, inspiratory muscle ...