Blar i Department of Clinical Science på tidsskrift "Frontiers in Endocrinology"
Viser treff 1-9 av 9
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Coexistence of Congenital Adrenal Hyperplasia and Autoimmune Addison's Disease
(Peer reviewed; Journal article, 2019-09-27)Background: Underlying causes of adrenal insufficiency include congenital adrenal hyperplasia (CAH) and autoimmune adrenocortical destruction leading to autoimmune Addison's disease (AAD). Here, we report a patient with a ... -
The effect of WnT pathway modulators on human iPSC-derived pancreatic beta cell maturation
(Peer reviewed; Journal article, 2019-05-08)Current published protocols for targeted differentiation of human stem cells toward pancreatic β-cells fail to deliver sufficiently mature cells with functional properties comparable to human islet β-cells. We aimed to ... -
Increased Plasma Soluble Interleukin-2 Receptor Alpha Levels in Patients With Long-Term Type 1 Diabetes With Vascular Complications Associated With IL2RA and PTPN2 Gene Polymorphisms
(Journal article; Peer reviewed, 2020)Type 1 diabetes (T1D) is largely considered an autoimmune disease leading to the destruction of insulin-producing pancreatic β cells. Further, patients with T1D have 3–4-fold increased risk of developing micro- and ... -
Metabolic and Epigenetic Regulation by Estrogen in Adipocytes
(Journal article; Peer reviewed, 2022-02-22)Sex hormones contribute to differences between males and females in body fat distribution and associated disease risk. Higher concentrations of estrogens are associated with a more gynoid body shape and with more fat storage ... -
Modulating Wnt signaling in human induced pluripotent stem cell-derived S7 cells
(Peer reviewed; Journal article, 2019)Current published protocols for targeted differentiation of human stem cells toward pancreatic β-cells fail to deliver sufficiently mature cells with functional properties comparable to human islet β-cells. We aimed to ... -
Multi-omics and machine learning for the prevention and management of female reproductive health
(Journal article; Peer reviewed, 2023)Females typically carry most of the burden of reproduction in mammals. In humans, this burden is exacerbated further, as the evolutionary advantage of a large and complex human brain came at a great cost of women’s ... -
Peripheral and central macrophages in obesity
(Journal article; Peer reviewed, 2023)Obesity is associated with chronic, low-grade inflammation. Excessive nutrient intake causes adipose tissue expansion, which may in turn cause cellular stress that triggers infiltration of pro-inflammatory immune cells ... -
Sex-Specific Limitations in Physical Health in Primary Adrenal Insufficiency
(Journal article; Peer reviewed, 2021)Background: Patients with primary adrenal insufficiency (PAI) suffer reduced quality of life (QoL), but comparisons with large-scale normative data are scarce. The clinical characteristics associated with reduced QoL are ... -
Subtype-specific surface proteins on adipose tissue macrophages and their association to obesity-induced insulin resistance
(Journal article; Peer reviewed, 2022)A chronic low-grade inflammation, originating in the adipose tissue, is considered a driver of obesity-associated insulin resistance. Macrophage composition in white adipose tissue is believed to contribute to the pathogenesis ...