Blar i Department of Clinical Science på tidsskrift "Molecular Oncology"
Viser treff 1-5 av 5
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Chromosomal instability and a deregulated cell cycle are intrinsic features of high-risk gastrointestinal stromal tumours with a metastatic potential
(Journal article; Peer reviewed, 2023)Patients with localised, high-risk gastrointestinal stromal tumours (GIST) benefit from adjuvant imatinib treatment. Still, approximately 40% of patients relapse within 3 years after adjuvant therapy and the clinical and ... -
FLT3-ITD mutations in acute myeloid leukaemia – molecular characteristics, distribution and numerical variation
(Journal article; Peer reviewed, 2021)Recurrent somatic internal tandem duplications (ITD) in the FMS-like tyrosine kinase 3 (FLT3) gene characterise approximately one third of patients with acute myeloid leukaemia (AML), and FLT3-ITD mutation status guides ... -
imPlatelet classifier: image-converted RNA biomarker profiles enable blood-based cancer diagnostics
(Journal article; Peer reviewed, 2021)Liquid biopsies offer a minimally invasive sample collection, outperforming traditional biopsies employed for cancer evaluation. The widely used material is blood, which is the source of tumor-educated platelets. Here, we ... -
Low Z-4OHtam concentrations are associated with adverse clinical outcome among early stage premenopausal breast cancer patients treated with adjuvant tamoxifen
(Journal article; Peer reviewed, 2021)Low steady‐state levels of active tamoxifen metabolites have been associated with inferior treatment outcomes. In this retrospective analysis of 406 estrogen receptor‐positive breast cancer (BC) patients receiving adjuvant ... -
Sex disparity in acute myeloid leukaemia with FLT3 internal tandem duplication mutations: implications for prognosis
(Journal article; Peer reviewed, 2021)Incidence, molecular presentation and outcome of acute myeloid leukaemia (AML) are influenced by sex, but little attention has been directed at untangling sex-related molecular and phenotypic differences between female and ...