Department of Clinical Science: Recent submissions

Now showing items 241-260 of 2318

    • Immune regulatory mechanisms in endocrine autoimmune disorders 

      Sjøgren, Thea (Doctoral thesis, 2023-09-15)
      Ulike mekanismer eksisterer for at immunforsvaret skal lære å skille det som er eget fra det som er fremmed, også kjent som immunologisk toleranse. I noen tilfeller brytes denne toleransen, noe som kan føre til at enkelte ...

    • Sex-specific responses in glucose-insulin homeostasis and lipoprotein-lipid components after high-dose supplementation with marine n-3 PUFAs in abdominal obesity: a randomized double-blind crossover study 

      Laupsa-Borge, Johnny; Grytten, Elise; Bohov, Pavol; Bjørndal, Bodil; Strand, Elin; SKORVE, JON; Nordrehaug, Jan Erik; Berge, Rolf Kristian; Rostrup, Espen; Mellgren, Gunnar; Dankel, Simon N; Nygård, Ottar Kjell (Journal article; Peer reviewed, 2023)
      Background: Clinical studies on effects of marine-derived omega-3 (n-3) polyunsaturated fatty acids (PUFAs), mainly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), and the plant-derived omega-6 (n-6) PUFA ...

    • Primary Treatment Effects for High-Grade Serous Ovarian Carcinoma Evaluated by Changes in Serum Metabolites and Lipoproteins 

      Torkildsen, Cecilie Fredvik; Austdal, Marie; Iversen, Ann-Charlotte; Bathen, Tone Frost; Giskeødegård, Guro F.; Nilsen, Elisabeth Berge; Iversen, Grete Alræk; Sande, Ragnar; Bjørge, Line; Thomsen, Liv Cecilie Vestrheim (Journal article; Peer reviewed, 2023)
      High-grade serous ovarian carcinoma (HGSOC) is the most common and deadliest ovarian cancer subtype. Despite advances in treatment, the overall prognosis remains poor. Regardless of efforts to develop biomarkers to predict ...

    • The use of 16S rRNA targeted next generation sequencing in diagnostics of polymicrobial invasive infections 

      Dyrhovden, Ruben (Doctoral thesis, 2023-08-21)
      16S rRNA dypsekvensering muliggjør, som vist i flere vitenskapelige arbeider, en mer fullstendig karakterisering av komplekse bakterielle mikrobiota enn det som kan oppnås ved tradisjonelle, dyrkningsbaserte, mikrobiologiske ...

    • Rationale and design of the Birkebeiner Ageing Study – a prospective cohort study of older endurance athletes 

      Myrstad, Marius; Johansen, Kristoffer Robin; Sørensen, Eivind; Ranhoff, Anette Hylen (Journal article; Peer reviewed, 2023)
      Background While regular physical activity is associated with reduced mortality and morbidity in general populations, health outcomes and functional capacity related to upholding strenuous endurance exercise beyond the ...

    • Obesity Is Associated with Distorted Proteoglycan Expression in Adipose Tissue 

      Meen, Astri Jeanette; Doncheva, Atanaska Ivanova; Böttcher, Yvonne; Dankel, Simon N; Hoffmann, Anne; Blüher, Matthias; Fernø, Johan; Mellgren, Gunnar; Ghosh, Adhideb; Sun, Wenfei; Dong, Hua; Noé, Falko; Wolfrum, Christian; Pejler, Gunnar; Dalen, Knut Tomas; Kolset, Svein Olav (Journal article; Peer reviewed, 2023)
      Proteoglycans are central components of the extracellular matrix (ECM) and binding partners for inflammatory chemokines. Morphological differences in the ECM and increased inflammation are prominent features of the white ...

    • Gut microbiota composition during hospitalization is associated with 60-day mortality after severe COVID-19 

      Trøseid, Marius; Holter, Jan Cato; Holm, Kristian; Vestad, Beate; Sazonova, Taisiia; Granerud, Beathe Kiland; Dyrhol-Riise, Anne Ma; Holten, Aleksander Rygh; Tonby, Kristian; Kildal, Anders Benjamin; Heggelund, Lars; Tveita, Anders Aune; Bøe, Simen; Müller, Karl Erik; Jenum, Synne; Hov, Johannes Espolin Roksund; Ueland, Thor (Journal article; Peer reviewed, 2023)
      Background Gut microbiota alterations have been reported in hospitalized COVID-19 patients, with reduced alpha diversity and altered microbiota composition related to respiratory failure. However, data regarding gut ...

    • Plasma-Metanephrines in Patients with Autoimmune Addison’s Disease with and without Residual Adrenocortical Function 

      Åkerman, Anna-Karin; Sævik, Åse Bjorvatn; Thorsby, Per Medbøe; Methlie, Paal; Quinkler, Marcus; Jørgensen, Anders Palmstrøm; Höybye, Charlotte; Debowska, Aleksandra; Nedrebø, Bjørn Gunnar; Dahle, Anne Lise; Carlsen, Siri; Tomkowicz, Aneta; Sollid, Stina Therese; Nermoen, Ingrid; Grønning, Kaja; Dahlqvist, Per; Grimnes, Guri; Skov, Jakob; Finnes, Trine Elisabeth; Wahlberg, Jeanette; Holte, Synnøve Emblem; Simunkova, Katerina; Kämpe, Olle; Husebye, Eystein Sverre; Øksnes, Marianne; Bensing, Sophie (Journal article; Peer reviewed, 2023-05-22)
      Purpose: Residual adrenocortical function, RAF, has recently been demonstrated in one-third of patients with autoimmune Addison’s disease (AAD). Here, we set out to explore any influence of RAF on the levels of plasma ...

    • Genetic effects on the timing of parturition and links to fetal birth weight 

      Solé-Navais, Pol; Flatley, Christopher; Steinthorsdottir, Valgerdur; Vaudel, Marc; Juodakis, Julius; Chen, Jing; Laisk, Triin; LaBella, Abigail L.; Westergaard, David; Bacelis, Jonas; Brumpton, Ben Michael; Skotte, Line; Borges, Maria C.; Helgeland, Øyvind; Mahajan, Anubha; Wielscher, Matthias; Lin, Frederick; Briggs, Catherine; Wang, Carol A.; Moen, Gunn-Helen Øiseth; Beaumont, Robin N.; Bradfield, Jonathan P.; Abraham, Abin; Thorleifsson, Gudmar; Gabrielsen, Maiken Elvestad; Ostrowski, Sisse R.; Modzelewska, Dominika; Nøhr, Ellen Aagaard; Hypponen, Elina; Srivastava, Amit; Talbot, Octavious; Allard, Catherine; Williams, Scott M.; Menon, Ramkumar; Shields, Beverley M.; Sveinbjornsson, Gardar; Xu, Huan; Melbye, Mads; Lowe, William; Bouchard, Luigi; Oken, Emily; Pedersen, Ole B.; Gudbjartsson, Daniel F.; Erikstrup, Christian; Sørensen, Erik; Lie, Rolv T.; Teramo, Kari; Hallman, Mikko; Juliusdottir, Thorhildur; Hakonarson, Hakon; Ullum, Henrik; Hattersley, Andrew T.; Sletner, Line; Merialdi, Mario; Rifas-Shiman, Sheryl L.; Steingrimsdottir, Thora; Scholtens, Denise; Power, Christine; West, Jane; Nyegaard, Mette; Capra, John A.; Skogholt, Anne Heidi; Magnus, Per Minor; Andreassen, Ole; Thorsteinsdottir, Unnur; Grant, Struan F. A.; Qvigstad, Elisabeth; Pennell, Craig E.; Hivert, Marie-France; Hayes, Geoffrey M.; Jarvelin, Marjo-Riitta; McCarthy, Mark I.; Lawlor, Deborah A.; Nielsen, Henriette S.; Mägi, Reedik; Rokas, Antonis; Hveem, Kristian; Stefansson, Kari; Feenstra, Bjarke; Njølstad, Pål Rasmus; Muglia, Louis J.; Freathy, Rachel M.; Johansson, Stefan; Zhang, Ge; Jacobsson, Bo (Journal article; Peer reviewed, 2023)
      The timing of parturition is crucial for neonatal survival and infant health. Yet, its genetic basis remains largely unresolved. We present a maternal genome-wide meta-analysis of gestational duration (n = 195,555), ...

    • Higher concentrations of kynurenic acid in CSF are associated with the slower clinical progression of Alzheimer's disease 

      Knapskog, Anne Brita; Aksnes, Mari; Edwin, Trine Holt; Ueland, Per Magne; Ulvik, Arve; Fang, Fei; Eldholm, Rannveig Sakshaug; Halaas, Nathalie Bodd; Saltvedt, Ingvild Tina; Giil, Lasse Melvær; Watne, Leiv (Journal article; Peer reviewed, 2023)
      Introduction: The kynurenine pathway's (KP) malfunction is closely related to Alzheimer's disease (AD), for antagonistic kynurenic acid (KA) and agonistic quinolinic acid act on the N-methyl-D-aspartate receptor, a possible ...

    • Multi-omics and machine learning for the prevention and management of female reproductive health 

      Kharb, Simmi; Joshi, Anagha (Journal article; Peer reviewed, 2023)
      Females typically carry most of the burden of reproduction in mammals. In humans, this burden is exacerbated further, as the evolutionary advantage of a large and complex human brain came at a great cost of women’s ...

    • Sexual dimorphism in selenium deficiency is associated with metabolic syndrome and prevalence of heart disease 

      Weening, Eerde H.; Al-Mubarak, Ali A.; Dokter, Martin M.; Dickstein, Kenneth; Lang, Chim C.; Ng, Leong L.; Metra, Marco; van Veldhuisen, Dirk J.; Touw, Daan J.; de Boer, Rudolf A.; Gansevoort, Ron T.; Voors, Adriaan A.; Bakker, Stephan J. L.; van der Meer, Peter; Bomer, Nils (Journal article; Peer reviewed, 2023)
      Background Serum selenium levels have been associated with the incidence of heart failure (HF) and signs of the metabolic syndrome. In addition, notable differences have been reported between males and females in food ...

    • A prospective study of pulmonary outcomes and chest computed tomography in the first year after COVID-19 

      Lerum, Tøri Vigeland; Meltzer, Carin; Rivero, Jezabel Rodriguez; Aaløkken, Trond Mogens; Brønstad, Eivind; Aarli, Bernt Bøgvald; Lund, Kristine Marie Aarberg; Durheim, Michael Thomas; Ashraf, Haseem; Einvik, Gunnar; Skjønsberg, Ole Henning; Stavem, Knut (Journal article; Peer reviewed, 2023)
      COVID-19 primarily affects the respiratory system. We aimed to evaluate how pulmonary outcomes develop after COVID-19 by assessing participants from the first pandemic wave prospectively 3 and 12 months following hospital ...

    • Deep phenotyping of pubertal development in Norwegian children: the Bergen Growth Study 2 

      Juliusson, Petur B.; Bruserud, Ingvild S.; Oehme, Ninnie Helen Bakken; Madsen, Andre; Forthun, Ingvild Halsør; Balthasar, Melissa Rajini; Viste, kristin; Jugessur, Astanand; Schell, Lawrence M.; Bjerknes, Robert; Roelants, Mathieu; Karen, Rosendahl (Journal article; Peer reviewed, 2023)
      Background The Bergen Growth Study 2 (BGS2) aims to characterise somatic and endocrine changes in healthy Norwegian children using a novel methodology. Subjects and methods A cross-sectional sample of 1285 children ...

    • No signs of neurodegenerative effects in 15q11.2 BP1-BP2 copy number variant carriers in the UK Biobank 

      Bøen, Rune; Kaufmann, Tobias; Frei, Oleksandr; van der Meer, Dennis; Djurovic, Srdjan; Andreassen, Ole; Selmer, Kaja Kristine; Alnæs, Dag; Sønderby, Ida Elken (Journal article; Peer reviewed, 2023)
      The 15q11.2 BP1-BP2 copy number variant (CNV) is associated with altered brain morphology and risk for atypical development, including increased risk for schizophrenia and learning difficulties for the deletion. However, ...

    • In silico analysis provides insights for patient-specific annuloplasty in Barlow’s disease 

      Aguilera, Hans Martin Dahl; Persson, Robert; Haaverstad, Rune; Skallerud, Bjørn Helge; Prot, Victorien Emile; Urheim, Stig (Journal article; Peer reviewed, 2023)
      Objective To predict the required mitral annular area reduction in patients with Barlow's disease to obtain a predefined leaflet area index by a novel in silico modeling method. Methods Three-dimensional echocardiography ...

    • Thawing plateau time indicating the duration of phase transition from ice to water is the strongest predictor for long-term durable pulmonary vein isolation after cryoballoon ablation for atrial fibrillation—Data from the index and repeat procedures 

      Shi, Libin; Wollner, Kristian; Chu, Song-Yun; Wang, Yu-Chuan; Solheim, Eivind; Schuster, Peter Moritz; Chen, Jian (Journal article; Peer reviewed, 2023)
      Introduction: This study aimed to clarify the relationship between the durability of pulmonary vein (PV) isolation and the time of phase transition from ice to water indicated by thawing plateau time in a cryoballoon ...

    • An expert consensus on the recommendations for the use of biomarkers in Fabry disease 

      Burlina, Allesandro; Brand, Eva; Hughes, Derralynn A.; Kantola, Ilkka; Krämer, Johannes; Nowak, Albina; Tøndel, Camilla; Wanner, Christoph; Spada, Marco (Journal article; Peer reviewed, 2023)
      Fabry disease is an X-linked lysosomal storage disorder caused by the accumulation of glycosphingolipids in various tissues and body fluids, leading to progressive organ damage and life-threatening complications. Phenotypic ...

    • Small airways obstruction and its risk factors in the Burden of Obstructive Lung Disease (BOLD) study: a multinational cross-sectional study 

      Knox-Brown, Ben; Patel, Jaymini; Potts, James; Ahmed, Rana; Aquart-Stewart, Althea; Cherkaski, Hamid Hacene; Denguezli, Meriam; Elbiaze, Mohammed; Elsony, Asma; Franssen, Frits M E; Ghobain, Mohammed Al; Harrabi, Imed; Janson, Christer; Jõgi, Rain; Juvekar, Sanjay; Lawin, Herve; Mannino, David; Mortimer, Kevin; Nafees, Asaad Ahmed; Nielsen, Rune; Obaseki, Daniel; Paraguas, Stefanni Nonna M; Rashid, Abdul; Loh, Li-Cher; Salvi, Sundeep; Seemungal, Terence; Studnicka, Michael; Tan, Wan C; Wouters, Emiel E F M; Barbara, Cristina; Gislason, Thorarinn; Gunasekera, Kirthi; Burney, Peter; Amaral, Andre F S (Journal article; Peer reviewed, 2023)
      Background Small airways obstruction is a common feature of obstructive lung diseases. Research is scarce on small airways obstruction, its global prevalence, and risk factors. We aimed to estimate the prevalence of small ...

    • Early response evaluation by single cell signaling profiling in acute myeloid leukemia 

      Tislevoll, Benedicte Sjo; Hellesøy, Monica; Fagerholt, Oda Helen Eck; Gullaksen, Stein-Erik; Srivastava, Aashish; Birkeland, Even; Kleftogiannis, Dimitrios; Ayuda Duran, Pilar; Piechaczyk, Laure Isabelle; Tadele, Dagim Shiferaw; Skavland, Jørn; Panagiotis, Baliakas; Hovland, Randi; Andresen, Vibeke; Seternes, Ole Morten; Tvedt, Tor Henrik Anderson; Aghaeepour, Nima; Gavasso, Sonia; Porkka, Kimmo; Jonassen, Inge; Fløisand, Yngvar; Enserink, Jorrit; Blaser, Nello; Gjertsen, Bjørn Tore (Journal article; Peer reviewed, 2023)
      Aberrant pro-survival signaling is a hallmark of cancer cells, but the response to chemotherapy is poorly understood. In this study, we investigate the initial signaling response to standard induction chemotherapy in a ...