Department of Clinical Science: Recent submissions

Now showing items 261-280 of 2318

    • Systemic immune activation profiles in streptococcal necrotizing soft tissue infections: A prospective multicenter study 

      Rath, Eivind; Palma Medina, Laura M.; Jahagirdar, Sanjeevan; Mosevoll, Knut Anders; Damås, Jan Kristian; Madsen, Martin B.; Svensson, Mattias; Hyldegaard, Ole; Martins dos Santos, Vitor A.P.; Saccenti, Edoardo; Norrby-Teglund, Anna; Skrede, Steinar; Bruun, Trond (Journal article; Peer reviewed, 2023)
      Objective Early stages with streptococcal necrotizing soft tissue infections (NSTIs) are often difficult to discern from cellulitis. Increased insight into inflammatory responses in streptococcal disease may guide correct ...

    • Relationship between Ketones, Ghrelin, and, Appetite on Isocaloric Diets with Varying Carbohydrate Quality and Amount: Results from a Randomized Controlled Trial in People with Obesity (CARBFUNC) 

      Horn, Cathrine; Gjerde, Eirin Semb; Laupsa-Borge, Johnny; Andersen, Amanda Iselin Olesen; Lawrence-Archer, Laurence; McCann, Adrian; Hansson, Patrik; Raza, Ghulam S.; Herzig, Karl Heinz; Lied, Gülen Arslan; Alho Letra Martins, Catia Patricia; Mellgren, Gunnar; Dierkes, Jutta; Dankel, Simon N (Journal article; Peer reviewed, 2023)
      Background Low-carbohydrate high-fat (LCHF) diets may suppress the increase in appetite otherwise seen after diet-induced fat loss. However, studies of diets without severe energy restriction are lacking, and the effects ...

    • Association of respiratory symptoms and lung function with occupation in the multinational Burden of Obstructive Lung Disease (BOLD) study 

      Ratanachina, Jate; Amaral, Andre F.S.; De Matteis, Sara; Lawin, Herve; Mortimer, Kevin; Obaseki, Daniel O.; Harrabi, Imed; Denguezli, Meriam; Wouters, Emiel F.M.; Janson, Christer; Nielsen, Rune; Gulsvik, Amund; Cherkaski, Hamid Hacene; Mejza, Filip; Mahesh, Padukudru Anand; Elsony, Asma; Ahmed, Rana; Tan, Wan C.; Loh, Li Cher; Rashid, Abdul; Studnicka, Michael; Nafees, Asaad A.; Seemungal, Terence; Aquart-Stewart, Althea; Al Ghobain, Mohammed; Zheng, Jinping; Juvekar, Sanjay; Salvi, Sundeep; Jogi, Rain; Mannino, David M.; Gislason, Thorarinn; Buist, A. Sonia; Cullinan, Paul; Burney, Peter G.J.; Hafizi, Hasan; Aliko, Anila; Bardhi, Donika; Tafa, Holta; Thanasi, Natasha; Mezini, Arian; Teferici, Alma; Todri, Dafina; Nikolla, Jolanda; Kazasi, Rezarta; Bengrait, Amira; Haddad, Tabarek; Zgaoula, Ibtissem; Ghit, Maamar; Roubhia, Abdelhamid; Boudra, Soumaya; Atoui, Feryal; Yakoubi, Randa; Benali, Rachid; Bencheikh, Abdelghani; Ait-Khaled, Nadia; Jenkins, Christine; Marks, Guy; Bird, Tessa; Espinel, Paola; Hardaker, Kate; Toelle, Brett; Dawes, Torkil; Lamprecht, Bernd; Schirhofer, Lea; Islam, Akramul; Ahmed, Syed Masud; Islam, Shayla; Islam, Qazi Shafayetul; Mesbah-Ul-Haque, NN; Chowdhury, Tridib Roy; Chatterjee, Sukantha Kumar; Mia, Dulal; Das, Shyamal Chandra; Rahman, Mizanur; Islam, Nazrul; Uddin, Shahaz; Islam, Nurul; Khatun, Luiza; Parvin, Monira; Khan, Abdul Awal; Islam, Maidul; Kpangon, Arsene; Kpossou, Karl; Agodokpessi, Gildas; Ayelo, Paul; Fayomi, Benjamin; Mbatchou, Bertrand; Ashu, Atongno Humphrey; Wang, Wen; Zhong, NanShan; Liu, Shengming; Lu, Jiachun; Ran, Pixin; Wang, Dali; Zhou, Yumin; Laja, Hendrik; Ulst, Katrin; Zobel, Vappu; Lill, Toomas-Julius; Adegnika, Ayola Akim; Welte, Tobias; Bodemann, Isabelle; Geldmacher, Henning; Schweda-Linow, Alexandra; Benedikdtsdottir, Bryndis; Jörundsdottir, Kristin; Gudmundsdottir, Lovisa; Gudmundsdottir, Sigrun; Gundmundsson, Gunnar; Koul, Parvaiz A.; Malik, Sajjad; Hakim, Nissar A.; Khan, Umar Hafiz; Chowgule, Rohini; Shetye, Vasant; Raphael, Jonelle; Almeda, Rosel; Tawde, Mahesh; Tadvi, Rafiq; Katkar, Sunil; Kadam, Milind; Dhanawade, Rupesh; Ghurup, Umesh; Hirve, Siddhi; Sambhudas, Somnath; Chaidhary, Bharat; Tambe, Meera; Pingale, Savita; Umap, Arati; Umap, Archana; Shelar, Nitin; Devchakke, Sampada; Chaudhary, Sharda; Bondre, Suvarna; Walke, Savita; Gawhane, Ashleshsa; Sapkal, Anil; Argade, Rupali; Gaikwad, Vijay; Brashier, Sundeep Bill; Londhe, Jyoti; Madas, Sapna; Aikman, Althea Akosua Francia; Sooronbaev, Talant M.; Estebesova, Bermet M.; Akmatalieva, Meerim; Usenbaeva, Saadat; Kydyrova, Jypara; Bostonova, Eliza; Sheraliev, Ulan; Marajapov, Nuridin; Toktogulova, Nurgul; Emilov, Berik; Azilova, Toktogul; Beishekeeva, Gulnara; Dononbaeva, Nasyikat; Tabyshova, Aijamal; Mwangoka, Ernest; Kambwili, Mayamiko; Chipeta, Martha; Banda, Gloria; Mkandawire, Suzgo; Banda, Justice; Sholehah, Siti; Benjelloun, Mohamed C.; Nejjari, Chakib; Elbiaze, Mohamed; El Rhazi, Karima; Franssen, F.F.E.; Wesseling, G.J.; Erhabor, Gregory; Awopeju, Olayemi; Adewole, Olufemi; Endresen, Tina; Svendsen, Lene Løvendahl; Irfan, Muhammad; Fatmi, Zafar; Zahidie, Aysha; Shaukat, Natasha; Iqbal, Meesha; Idolor, Luisito F.; de Guia, Teresita S.; Francisco, Norberto A.; Roa, Camilo C.; Ayuyao, Fernando G.; Tady, Cecil Z.; Tan, Daniel T.; Banal-Yang, Sylvia; Balanag, Vincent M.; Reyes, Maria Teresita N.; Dantes, Renato B.; Amarillo, Lourdes; Berratio, Lakan U.; Fernandez, Lenora C.; Garcia, Gerard S.; Naval, Sullian S.; Reyes, Thessa; Roa, Camilo C.; Sanchez, Ma. Flordeliza; Simpao, Leander P.; Nizankowska-Mogilnicka, Ewa; Frey, Jakub; Harat, Rafal; Nastalek, Pawel; Pajak, Andrzej; Skucha, Wojciech; Szczeklik, Andrzej; Twardowska, Magda; Bárbara, Cristina; Rodrigues, Fátima; Dias, Hermínia; Cardoso, João; Almeida, João; Matos, Maria João; Simão, Paula; Santos, Moutinho; Ferreira, Reis; Alorainy, H.; El-Hamad, E.; Al Hajjaj, Hajjaj; Hashi, A.; Dela, R.; Fanuncio, R.; Doloriel, E.; Marciano, I.; Safia, L.; Bateman, Eric; Jithoo, Anamika; Adams, Desiree; Barnes, Edward; Freeman, Jasper; Hayes, Anton; Hlengwa, Sipho; Johannisen, Christine; Koopman, Mariana; Louw, Innocentia; Ludick, Ina; Olckers, Alta; Ryck, Johanna; Storbeck, Janita; Gunasekera, Kirthi; Wickremasinghe, Rajitha; Elsadig, Hana A.; Osman, Nada Bakery; Noory, Bandar Salah; Mohamed, Monjda Awad; Osman, Hasab Alrasoul Akasha Ahmed; ed Elhassan, Namarig Moham; El Zain, Abdel Mu'is; Mohamaden, Marwa Mohamed; Khalifa, Suhaiba; Elhadi, Mahmoud; Hassan, Mohand; Abdelmonam, Dalia; Kamal, Rashid; Eltigani, Hind; Umar, Stephen's; Abdeen, Aya; Osman, Mihad; Mohamed, Malaz; Eltayeb, Roa; Abelazeez, Mohamed; Altaher, Hoyam; Mohamed, Lina; Abdarahman, Rabee; Mohamed, Rayan; Haram, NN; Ismaeel, Rimaz; Olafsdottir, Inga Sif; Nisser, Katarina; Spetz-Nyström, Ulrike; Hägg, Gunilla; Lund, Gun-Marie; Lutchmansingh, Fallon; Conyette, Liane; Tabka, Zouhair; Daldoul, Hager; Boukheroufa, Zaki; Chouikha, Firas; Khalifa, Wahbi Belhaj; Kocabaş, Ali; Hancioglu, Attila; Hanta, Ismail; Kuleci, Sedat; Turkyilmaz, Ahmet Sinan; Umut, Sema; Unalan, Turgay; Gnatiuc, Louisa; Azar, Hadia; Patel, Jaymini; Amor, Caron; Potts, James; Tumilty, Michael; McLean, Fiona; Dudhaiya, Risha; McBurnie, Mary Ann; Vollmer, William M.; Gillespie, Suzanne; Sullivan, Sean; Lee, Todd A.; Weiss, Kevin B.; Jensen, Robert L.; Crapo, Robert; Enright, Paul; Cain, John; Copeland, Rebecca; Hazen, Dana; Methvin, Jennifer (Journal article; Peer reviewed, 2023)
      Background Chronic obstructive pulmonary disease has been associated with exposures in the workplace. We aimed to assess the association of respiratory symptoms and lung function with occupation in the Burden of Obstructive ...

    • Functional Analyses of Rare Germline Missense BRCA1 Variants Located within and outside Protein Domains with Known Functions 

      Hovland, Henrikke Nilsen; Mchaina, Eunice Kabanyana; Vetti, Hildegunn Høberg; Ariansen, Sarah Louise; Sjursen, Wenche; Van Ghelue, Marijke; Haukanes, Bjørn Ivar; Knappskog, Per Morten; Aukrust, Ingvild; Berge, Elisabet Ognedal (Journal article; Peer reviewed, 2023-01-19)
      The BRCA1 protein is implicated in numerous important cellular processes to prevent genomic instability and tumorigenesis, and pathogenic germline variants predispose carriers to hereditary breast and ovarian cancer (HBOC). ...

    • Systemic metabolomic profiles in adult patients with bacterial sepsis: Characterization of patient heterogeneity at the time of diagnosis 

      Mosevoll, Knut Anders; Hansen, Bent-Are; Gundersen, Ingunn Margareetta; Reikvam, Håkon; Bruserud, Øyvind; Bruserud, Øystein; Wendelbo, Øystein (Journal article; Peer reviewed, 2023-01-24)
      Sepsis is a dysregulated host response to infection that causes potentially life-threatening organ dysfunction. We investigated the serum metabolomic profile at hospital admission for patients with bacterial sepsis. The ...

    • Genetic determinants of macrolide and tetracycline resistance in penicillin non-susceptible Streptococcus pneumoniae isolates from people living with HIV in Dar es Salaam, Tanzania 

      Manyahi, Joel; Moyo, Sabrina John; Langeland, Nina; Blomberg, Bjørn (Journal article; Peer reviewed, 2023-02-20)
      Background: Over one million yearly deaths are attributable to Streptococcus pneumoniae and people living with HIV are particularly vulnerable. Emerging penicillin non-susceptible Streptococcus pneumoniae (PNSP) challenges ...

    • Optimization of bacterial DNA and endotoxin extraction from settled airborne dust 

      Abouelhana, Hesham Amin Mohamed; Marshall, Ian P.G.; Bertelsen, Randi Jacobsen; Wouters, Inge M.; Schlünssen, Vivi; Sigsgaard, Torben; Šantl-Temkiv, Tina (Journal article; Peer reviewed, 2023)
      Collecting and obtaining sufficient amount of airborne particles for multiple microbial component assessments can be challenging. A passive dust sampling device, the electrostatic dust fall collector (EDC) has been established ...

    • Changes in mental health symptoms from April (COVID-19 outbreak) to December 2020 in Norway: A two-wave study 

      Hagen, Kristen; Solem, Stian; Stavrum, Anne-Kristin Støbakk; Eid, Jarle; Kvale, Gerd; Samdal, Oddrun; Hellard, Stephanie Francoise Claire Le (Journal article; Peer reviewed, 2023)
      The main objective of the study was to investigate changes in mental health symptoms from the start of the pandemic in Norway (April) to December 2020. A total of 6017 participants completed an assessment of the survey at ...

    • Correlation between Murmurs and Echocardiographic Findings; From an Imaging Cardiologist Point of View 

      Saeed, Sahrai; Mohamed Ali, Abukar; Wasim, Daanyaal; Risnes, Ivar; Urheim, Stig (Journal article; Peer reviewed, 2023)
      A heart murmur in adults is a common reason for referral for echocardiography at most general cardiology clinics in Europe. A murmur may indicate either a mild age-related valvular calcification or regurgitation, or represent ...

    • Genetic diversity in the metronidazole metabolism genes nitroreductases and pyruvate ferredoxin oxidoreductases in susceptible and refractory clinical samples of Giardia lamblia 

      Saghaug, Christina Skår; Gamlem, Astrid Leinebø; Hauge, Kirsti Brugrand; Vahokoski, Juha; Klotz, Christian; Aebischer, Toni; Langeland, Nina; Hanevik, Kurt (Journal article; Peer reviewed, 2023)
      The effectiveness of metronidazole against the tetraploid intestinal parasite Giardia lamblia is dependent on its activation/inactivation within the cytoplasm. There are several activating enzymes, including pyruvate ...

    • Serumkonsentrasjonsmåling av gentamicin hos barn 

      Grodås, Karolina Teresa Maulen; Døllner, Henrik; Thaulow, Christian Magnus; Knudsen, Per Kristian; Tønnessen, Anders; Skeibrok, Mari; Klingenberg, Claus Andreas (Journal article; Peer reviewed, 2023)
      BAKGRUNN Gentamicin brukes ofte ved alvorlige infeksjoner hos barn. Det har vært rutine i Norge å måle serumkonsentrasjon av gentamicin rett før andre eller tredje dose (0-prøve) for å vurdere risiko for toksisitet. Den ...

    • High-normal blood pressure in midlife is a stronger risk factor for incident hypertension 26 years later in women than men: the Hordaland Health Study 

      Ohldieck, Annabel Eide; Kringeland, Ester Anne; Midtbø, Helga Bergljot; Tell, Grethe S.; Gerdts, Eva (Journal article; Peer reviewed, 2023)
      Purpose To identify modifiable risk factors in early midlife associated with incident hypertension 26 years later in women and men. Materials and methods We used data from 1025 women and 703 men in the community-based ...

    • Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk 

      Shrine, Nick; Izquierdo, Abril G.; Chen, Jing; Packer, Richard; Hall, Robert J.; Guyatt, Anna L.; Batini, Chiara; Thompson, Rebecca J.; Pavuluri, Chandan; Malik, Vidhi; Hobbs, Brian D.; Moll, Matthew; Kim, Wonji; Tal-Singer, Ruth; Bakke, Per S.; Fawcett, Katherine A.; John, Catherine; Coley, Kayesha; Piga, Noemi Nicole; Pozarickij, Alfred; Lin, Kuang; Millwood, Iona Y.; Chen, Zhengming; Li, Liming; Wijnant, Sara R A; Lahousse, Lies; Brusselle, Guy; Uitterlinden, Andre G.; Manichaikul, Ani; Oelsner, Elizabeth C.; Rich, Stephen S.; Barr, R Graham; Kerr, Shona M.; Vitart, Veronique; Brown, Michael R.; Wielscher, Matthias; Imboden, Medea; Jeong, Ayoung; Bartz, Traci M.; Gharib, Sina A.; Flexeder, Claudia; Karrasch, Stefan; Gieger, Christian; Peters, Annette; Stubbe, Beate; Hu, Xiaowei; Ortega, Victor E.; Meyers, Deborah A.; Bleecker, Eugene R.; Gabriel, Stacey B.; Gupta, Namrata; Smith, Albert Vernon; Luan, Jian'an; Zhao, Jing-Hua; Hansen, Ailin Falkmo; Langhammer, Arnulf; Willer, Cristen; Bhatta, Laxmi; Porteous, David; Smith, Blair H.; Campbell, Archie; Sofer, Tamar; Lee, Jiwon; Daviglus, Martha L.; Yu, Bing; Lim, Elise; Xu, Hanfei; O'Connor, George T.; Thareja, Gaurav; Albagha, Omar M E; Suhre, Karsten; Granell, Raquel; Faquih, Tariq O.; Hiemstra, Pieter S.; Slats, Annelies M.; Mullin, Benjamin H.; Hui, Jennie; James, Alan; Beilby, John; Patasova, Karina; Hysi, Pirro; Koskela, Jukka T.; Wyss, Annah B.; Jin, Jianping; Sikdar, Sinjini; Lee, Mikyeong; May-Wilson, Sebastian; Pirastu, Nicola; Kentistou, Katherine A.; Joshi, Peter K.; Timmers, Paul R H J; Williams, Alexander T.; Free, Robert C.; Wang, Xueyang; Morrison, John L.; Gilliland, Frank D.; Chen, Zhanghua; Wang, Carol A.; Foong, Rachel E.; Harris, Sarah E.; Taylor, Adele; Redmond, Paul; Cook, James P.; Mahajan, Anubha; Lind, Lars; Palviainen, Teemu; Lehtimäki, Terho; Raitakari, Olli T.; Kaprio, Jaakko; Rantanen, Taina; Pietiläinen, Kirsi H.; Cox, Simon R.; Pennell, Craig E.; Hall, Graham L.; Gauderman, W James; Brightling, Chris; Wilson, James F.; Vasankari, Tuula; Laitinen, Tarja; Salomaa, Veikko; Mook-Kanamori, Dennis O.; Timpson, Nicholas J.; Zeggini, Eleftheria; Dupuis, Josée; Hayward, Caroline; Brumpton, Ben Michael; Langenberg, Claudia; Weiss, Stefan; Homuth, Georg; Schmidt, Carsten Oliver; Probst-Hensch, Nicole; Jarvelin, Marjo-Riitta; Morrison, Alanna C.; Polasek, Ozren; Rudan, Igor; Lee, Joo-Hyeon; Sayers, Ian; Rawlins, Emma L.; Dudbridge, Frank; Silverman, Edwin K.; Strachan, David P.; Walters, Robin G.; Morris, Andrew P.; London, Stephanie J.; Cho, Michael H.; Wain, Louise V.; Hall, Ian P.; Tobin, Martin D. (Journal article; Peer reviewed, 2023)
      Lung-function impairment underlies chronic obstructive pulmonary disease (COPD) and predicts mortality. In the largest multi-ancestry genome-wide association meta-analysis of lung function to date, comprising 580,869 ...

    • Investigating the rationale for COPD maintenance therapy prescription across Europe, findings from a multi-country study 

      Kocks, Janwillem; Ferreira, António Jorge; Bakke, Per S.; van Schayck, Onno C. P.; Ekroos, Heikki; Tzanakis, Nikolaos; Soulard, Stéphane; Haaksma-Herczegh, Monika; Mestres-Simon, Montserrat; Águila-Fuentes, Malena; Cataldo, Didier (Journal article; Peer reviewed, 2023)
      This study aims to understand healthcare professionals’ thoughts and motivations about optimal management and treatment of patients with chronic obstructive pulmonary disease (COPD). We conducted a DELPHI survey through ...

    • Kronisk transplantat-mot-vertsykdom 

      Rørvik, Synne Dragesund; Abrahamsen, Ingerid Weum; Myhre, Anders Eivind; Vo, Camilla Dao; Meling, Eva Ødegaard; Bruserud, Øystein; Gedde-Dahl, Tobias; Tvedt, Tor Henrik Anderson (Journal article; Peer reviewed, 2023)
      Kronisk transplantat-mot-vert-sykdom er en senkomplikasjon etter allogen stamcelletransplantasjon, og medfører kronisk inflammasjon og fibrose i forskjellige organer på grunn av feil regulering av donors immunceller. ...

    • Host blood-based biosignatures for subclinical TB and incipient TB: A prospective study of adult TB household contacts in Southern India 

      Sivakumaran, Dhanasekaran; Jenum, Synne; Srivastava, Aashish; Steen, Vidar Martin; Vaz, Mario; Doherty, Timothy Mark; Ritz, Christian; Grewal, Harleen (Journal article; Peer reviewed, 2023-01-11)
      A large proportion of the global tuberculosis (TB) burden is asymptomatic and not detectable by symptom-based screening, driving the TB epidemic through continued M. tuberculosis transmission. Currently, no validated tools ...

    • Transcriptional and functional effects of lithium in bipolar disorder iPSC-derived cortical spheroids 

      Osete, Jordi Requena; Akkouh, Ibrahim Ahmed; Levglevskyi, Oleksandr; Vandenberghe, Matthieu; Reis de Assis, Denis; Ueland, Thor; Kondratskaya, Elena; Holen, Børge; Szabo, Attila; Hughes, Timothy; Smeland, Olav Bjerkehagen; Steen, Vidar Martin; Andreassen, Ole; Djurovic, Srdjan (Journal article; Peer reviewed, 2023)
      Lithium (Li) is recommended for long-term treatment of bipolar disorder (BD). However, its mechanism of action is still poorly understood. Induced pluripotent stem cell (iPSC)-derived brain organoids have emerged as a ...

    • Myocardial function including estimates of myocardial work in young adults born very preterm or with extremely low birthweight - a cohort study 

      Engan, Britt; Omdal, Tom Roar; Greve, Gottfried; Vollsæter, Maria; Leirgul, Elisabeth (Journal article; Peer reviewed, 2023)
      Background Preterm birth and low birthweight have been associated with increased risk of heart failure and cardiovascular disease in young adulthood. However, results from clinical studies of myocardial function are not ...

    • Endothelial dysfunction in ME/CFS patients 

      Sandvik, Miriam Kristine; Sørland, Kari; Leirgul, Elisabeth; Rekeland, Ingrid Gurvin; Stavland, Christina Særsten; Mella, Olav; Fluge, Øystein (Journal article; Peer reviewed, 2023-02-02)
      Objective: A few earlier studies have found impaired endothelial function in patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). The present study investigated large-vessel and small-vessel endothelial ...

    • Cytokine concentrations in plasma from children with severe and non-severe community acquired pneumonia 

      Haugen, Johanne; Chandyo, Ram Krishna; Brokstad, Karl Albert; Mathisen, Maria; Ulak, Manjeswori; Basnet, Sudha; Valentiner-Branth, Palle; Strand, Tor (Journal article; Peer reviewed, 2015-09-25)
      Background: Children in low and middle-income countries have a high burden of pneumonia. Measuring the cytokine responses may be useful to identify novel markers for diagnosing, monitoring, and treating pneumonia. Objective: ...