Department of Clinical Science: Recent submissions
Now showing items 401-420 of 2318
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The prognostic value of pre-treatment circulating biomarkers of systemic inflammation (CRP, dNLR, YKL-40, and IL-6) in vulnerable older patients with metastatic colorectal cancer receiving palliative chemotherapy—The Randomized NORDIC9-Study
(Journal article; Peer reviewed, 2022)Appropriate patient selection for palliative chemotherapy is crucial in patients with metastatic colorectal cancer (mCRC). We investigated the prognostic value of C-reactive protein (CRP), derived neutrophil-to-lymphocyte ... -
Cerebrospinal fluid quinolinic acid is strongly associated with delirium and mortality in hip fracture patients
(Journal article; Peer reviewed, 2022)Background: The kynurenine pathway (KP) has been identified as a potential mediator linking acute illness to cognitive dysfunction by generating neuroactive metabolites in response to inflammation. Delirium (acute confusion) ... -
PARP-inhibition reprograms macrophages toward an anti-tumor phenotype
(Journal article; Peer reviewed, 2022)Poly(ADP)ribosylation inhibitors (PARPis) are toxic to cancer cells with homologous recombination (HR) deficiency but not to HR-proficient cells in the tumor microenvironment (TME), including tumor-associated macrophages ... -
Constitutional BRCA1 methylation and risk of incident triple-negative breast cancer and high-grade serous ovarian cancer
(Journal article; Peer reviewed, 2022)Importance About 25% of all triple-negative breast cancers (TNBCs) and 10% to 20% of high-grade serous ovarian cancers (HGSOCs) harbor BRCA1 promoter methylation. While constitutional BRCA1 promoter methylation has been ... -
The evolution of humoral immune responses to past and novel influenza virus strains gives evidence for antigenic seniority
(Journal article; Peer reviewed, 2022)The high genetic and antigenic variability of influenza virus and the repeated exposures of individuals to the virus over time account for the human immune responses toward this pathogen to continuously evolve during the ... -
Strong association of combined genetic deficiencies in the classical complement pathway with risk of systemic lupus erythematosus and primary Sjögren's syndrome
(Journal article; Peer reviewed, 2022)Objective Complete genetic deficiency of the complement component C2 is a strong risk factor for monogenic systemic lupus erythematosus (SLE), but whether heterozygous C2 deficiency adds to the risk of SLE or primary ... -
Stage-dependent prognostic shift in mismatch repair-deficient tumors: Assessing patient outcomes in stage II and III colon cancer
(Journal article; Peer reviewed, 2022)Introduction: Deficient mismatch repair (dMMR) or high microsatellite instability (MSI-H) is associated with an improved prognosis in colon cancer stage II but poor prognosis in stage IV colon cancer. The clinical significance ... -
Clinical Characteristics and Histopathology in Suspected Necrotizing Soft Tissue Infections
(Journal article; Peer reviewed, 2022)Background Necrotizing soft tissue infections (NSTIs) are severe diseases with high morbidity and mortality. The diagnosis is challenging. Several guidelines recommend tissue biopsies as an adjunct diagnostic in routine ... -
Cleaning at work and at home as related to lung health : With a focus on asthma, COPD and lung function decline, vulnerability established early in life and potential impact for the next generation
(Doctoral thesis, 2023-01-20)Bakgrunn Renhold er en dagligdags oppgave for mange, men betyr også eksponering for renholdskjemikalier og desinfeksjonsmidler som kan være skadelige for luftveiene og forårsake lungesykdom. Astma er den vanligste ... -
Use of antihistamines before or during pregnancy and risk of early-onset pre-eclampsia in allergic women: a population-based cohort study
(Journal article; Peer reviewed, 2022)Objective: We have previously found that allergy is a risk factor for early-onset pre-eclampsia. The aim of this study was to assess the association between pregestational maternal use of antihistamines and early-onset ... -
Single-cell protein profiling in early therapy response evaluation of acute myeloid leukemia by mass cytometry
(Doctoral thesis, 2023-01-19)Akutt myelogen leukemi er ein aggressiv og heterogen form for blodkreft med om lag 150 nye tilfelle årleg i Noreg. Med ei total overlevingsrate på 25% har den dårlig prognose, særlig blant eldre. Behandlinga består av eit ... -
A longitudinal study of the pulmonary mycobiome in subjects with and without chronic obstructive pulmonary disease
(Journal article; Peer reviewed, 2022-05-12)Background: Few studies have examined the stability of the pulmonary mycobiome. We report longitudinal changes in the oral and pulmonary mycobiome of participants with and without COPD in a large-scale bronchoscopy study ... -
The absent/low expression of CD34 in NPM1-mutated AML is not related to cytoplasmic dislocation of NPM1 mutant protein
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Contextual factors influencing medicines-related interventions to support safe transitions for care home residents post hospital discharge: a systematic review and meta-ethnographic synthesis
(Journal article; Peer reviewed, 2022)Background Residents of care or nursing homes are at a higher risk of medication-related harm, especially during care transitions. No medicines-related intervention has been identified that supports the safe transition ... -
Activity monitoring and patient-reported outcome measures in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome patients
(Journal article; Peer reviewed, 2022-09-19)Introduction: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a disease with no validated specific and sensitive biomarker, and no standard approved treatment. In this observational study with no intervention, ... -
A theory-informed systematic review of barriers and enablers to implementing multi-drug pharmacogenomic testing
(Journal article; Peer reviewed, 2022)PGx testing requires a complex set of activities undertaken by practitioners and patients, resulting in varying implementation success. This systematic review aimed (PROSPERO: CRD42019150940) to identify barriers and ... -
Decision support system and outcome prediction in a cohort of patients with necrotizing soft-tissue infections
(Journal article; Peer reviewed, 2022)Introduction: Necrotizing Soft Tissue Infections (NSTI) are severe infections with high mortality affecting a heterogeneous patient population. There is a need for a clinical decision support system which predicts outcomes ... -
IL-6 Responsiveness of CD4+ and CD8+ T Cells after Allogeneic Stem Cell Transplantation Differs between Patients and Is Associated with Previous Acute Graft versus Host Disease and Pretransplant Antithymocyte Globulin Therapy
(Journal article; Peer reviewed, 2022)Graft-versus-host disease (GVHD), one of the most common and serious complications after allogeneic stem cell transplantation, is mediated by allocative T cells. IL-6 mediates both pro- and anti-inflammatory effects and ... -
Guideline-Recommended Time Less Than 90 Minutes From ECG to Primary Percutaneous Coronary Intervention for ST-Segment–Elevation Myocardial Infarction Is Associated with Major Survival Benefits, Especially in Octogenarians: A Contemporary Report in 11 226 Patients from NORIC
(Journal article; Peer reviewed, 2022)Background Using contemporary data from NORIC (Norwegian Registry of Invasive Cardiology) we investigated the predictive value of patient age and time from ECG diagnosis to sheath insertion (ECG‐2‐sheath) in primary ... -
High levels of discordant antimicrobial therapy in hospital-acquired bloodstream infections is associated with increased mortality in an intensive care, low antimicrobial resistance setting
(Journal article; Peer reviewed, 2022)Background Bloodstream infections (BSI) occur frequently and are associated with severe outcomes. In this study we aimed to investigate proportions of patients that received discordant empirical antimicrobial therapy and ...