Department of Clinical Science: Recent submissions
Now showing items 501-520 of 2318
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Clinical studies of epidemic influenza and pandemic COVID-19 to improve the chain of patient care: from bedside diagnostics to long-term complications :
(Doctoral thesis, 2022-11-29)Tidlig diagnostikk og rask og målrettet behandling kan forbedre utfallet av influensa og Covid-19 sykdom. Gjennom prospektive, kontrollerte observasjonsstudier har vi vist betydningen av rask diagnostikk for å redusere ... -
Exercise-induced laryngeal obstruction (EILO) in athletes: a narrative review by a subgroup of the IOC Consensus on 'acute respiratory illness in the athlete'
(Journal article; Peer reviewed, 2022)Exercise-induced laryngeal obstruction (EILO) is caused by paradoxical inspiratory adduction of laryngeal structures during exercise. EILO is an important cause of upper airway dysfunction in young individuals and athletes, ... -
Circulating trimethylamine N-oxide levels do not predict 10-year survival in patients with or without coronary heart disease
(Journal article; Peer reviewed, 2022)Background Trimethylamine N-oxide (TMAO) is an amine oxide generated by gut microbial metabolism. TMAO may contribute to atherothrombosis and systemic inflammation. However, the prognostic value of circulating TMAO for ... -
Health Literacy and Risk Factors for Coronary Artery Disease (From the CONCARD PCI Study)
(Journal article; Peer reviewed, 2022)In the setting of established coronary artery disease (CAD), lower health literacy is associated with poor outcomes. The aim of this study was to determine whether health literacy at the index admission was associated with ... -
Implementation of a dual platelet inventory in a tertiary hospital during the COVID-19 pandemic enabling cold-stored apheresis platelets for treatment of actively bleeding patients
(Journal article; Peer reviewed, 2022)Background: To increase preparedness and mitigate the risk of platelet shortage without increasing the number of collections, we introduced a dual platelet inventory with cold-stored platelets (CSP) with 14-days shelf life ... -
Plasma protein biomarkers for the detection of pancreatic neuroendocrine tumors and differentiation from small intestinal neuroendocrine tumors
(Journal article; Peer reviewed, 2022)There is an unmet need for novel biomarkers to diagnose and monitor patients with neuroendocrine neoplasms. The EXPLAIN study explores a multi-plasma protein and supervised machine learning strategy to improve the diagnosis ... -
Social and genetic associations with educational performance in a Scandinavian welfare state
(Journal article; Peer reviewed, 2022)Recent research has suggested that across Western developed societies, the influence of genetics on educational outcomes is relatively constant. However, the degree to which family environment matters varies, such that ... -
A comparison of risk factors for cryptosporidiosis and non-cryptosporidiosis diarrhoea: A case-case-control study in Ethiopian children
(Journal article; Peer reviewed, 2022)Background: Cryptosporidiosis is a major cause of diarrhoea in young children in low-and-middle-income countries. New interventions should be informed by evidence pertaining to risk factors and their relative importance. ... -
Oocyst Shedding Dynamics in Children with Cryptosporidiosis: a Prospective Clinical Case Series in Ethiopia
(Journal article; Peer reviewed, 2022)Knowledge on the duration of Cryptosporidium oocyst shedding, and how shedding may be affected by subtypes and clinical parameters, is limited. Reduced transmission may be a secondary benefit of cryptosporidiosis treatment ... -
A non-coding RNA balancing act: miR-346-induced DNA damage is limited by the long non-coding RNA NORAD in prostate cancer
(Journal article; Peer reviewed, 2022-03-22)Background: miR-346 was identified as an activator of Androgen Receptor (AR) signalling that associates with DNA damage response (DDR)-linked transcripts in prostate cancer (PC). We sought to delineate the impact of miR-346 ... -
Risk estimates of imminent cardiovascular death and heart failure hospitalization are improved using serial natriuretic peptide measurements in patients With coronary artery disease and type 2 diabetes
(Journal article; Peer reviewed, 2022)Background: Baseline and temporal changes in natriuretic peptide (NP) concentrations have strong prognostic value with regard to long‐term cardiovascular risk stratification. To increase the clinical utility of NP sampling ... -
Survival According to Primary Tumor Location, Stage, and Treatment Patterns in Locoregional Gastroenteropancreatic High-grade Neuroendocrine Carcinomas
(Journal article; Peer reviewed, 2022)Background: Although the gastrointestinal tract (including the pancreas, gastroenteropancreatic (GEP) is the most common site for extrapulmonary neuroendocrine carcinoma (NEC), the current treatment patterns of locoregional ... -
Conserved metabolic enzymes as vaccine antigens for giardiasis
(Journal article; Peer reviewed, 2022-04-25)Giardia lamblia is a leading protozoal cause of diarrheal disease worldwide. Infection is associated with abdominal pain, malabsorption and weight loss, and protracted post-infectious syndromes. A human vaccine is not ... -
Continuation of fluoropyrimidine treatment with S-1 after cardiotoxicity on capecitabine- or 5-fluorouracil-based therapy in patients with solid tumours: a multicentre retrospective observational cohort study
(Journal article; Peer reviewed, 2022)Background Capecitabine- or 5-fluorouracil (5-FU)-based chemotherapy is widely used in many solid tumours, but is associated with cardiotoxicity. S-1 is a fluoropyrimidine with low rates of cardiotoxicity, but evidence ... -
The curse of the uncultured fungus
(Journal article; Peer reviewed, 2022)The international DNA sequence databases abound in fungal sequences not annotated beyond the kingdom level, typically bearing names such as “uncultured fungus”. These sequences beget low-resolution mycological results and ... -
Are infants exposed to antimicrobials during the first 3 months of life at increased risk of recurrent use? An explorative data-linkage study
(Journal article; Peer reviewed, 2022)Objectives: To investigate whether infants exposed to antimicrobials in hospital during the first 3 months of life had an increased risk of ambulatory antimicrobial use during the following year compared with infants not ... -
Antibiotic Use in a Cohort of Norwegian Children and Neonates Before, During and After Hospitalisation : Exploring focus areas for antibiotic stewardship
(Doctoral thesis, 2022-11-22)Bakgrunn: Rasjonell antibiotikabruk blant barn er essensielt for å unngå økende antibiotikaresistens samt forstyrrelser i deres normale bakterieflora. Formål: Hensikten med dette prosjektet var å tilegne oss en bedre ... -
A saturated map of common genetic variants associated with human height
(Journal article; Peer reviewed, 2022)Common single-nucleotide polymorphisms (SNPs) are predicted to collectively explain 40–50% of phenotypic variation in human height, but identifying the specific variants and associated regions requires huge sample sizes1. ... -
Cow Farmers’ Homes Host More Diverse Airborne Bacterial Communities Than Pig Farmers’ Homes and Suburban Homes
(Journal article; Peer reviewed, 2022)Living on a farm has been linked to a lower risk of immunoregulatory disorders, such as asthma, allergy, and inflammatory bowel disease. It is hypothesized that a decrease in the diversity and composition of indoor microbial ... -
Finite element analysis of mitral valve annuloplasty in Barlow's disease
(Journal article; Peer reviewed, 2022)Barlow’s Disease affects the entire mitral valve apparatus causing mitral regurgitation. Standard annuloplasty procedures lead to an average of 55% annular area reduction of the end diastolic pre-operative annular area in ...