Department of Clinical Science: Nye registreringer

Viser treff 201-220 av 2318

    • Obesity-associated changes in molecular biology of primary breast cancer 

      Nguyen, Ha-Linh; Geukens, Tatjana; Maetens, Marion; Aparicio, Samuel; Bassez, Ayse; Borg, Ake; Brock, Jane; Broeks, Annegien; Caldas, Carlos; Cardoso, Fatima; De Schepper, Maxim; Delorenzi, Mauro; Drukker, Caroline A.; Glas, Annuska M.; Green, Andrew R.; Isnaldi, Edoardo; Eyfjörð, Jórunn; Khout, Hazem; Knappskog, Stian; Krishnamurthy, Savitri; Lakhani, Sunil R.; Langerød, Anita; Martens, John W. M.; McCart Reed, Amy E.; Murphy, Leigh; Naulaerts, Stefan; Nik-Zainal, Serena; Nevelsteen, Ines; Neven, Patrick; Piccart, Martine; Poncet, Coralie; Punie, Kevin; Purdie, Colin; Rakha, Emad A.; Richardson, Andrea; Rutgers, Emiel; Vincent-Salomon, Anne; Simpson, Peter T.; Schmidt, Marjanka K.; Sotiriou, Christos; Span, Paul N.; Tan, Kiat Tee Benita; Thompson, Alastair; Tommasi, Stefania; Van Baelen, Karen; Van de Vijver, Marc; Van Laere, Steven; van’t Veer, Laura; Viale, Giuseppe; Viari, Alain; Vos, Hanne; Witteveen, Anke T.; Wildiers, Hans; Floris, Giuseppe; Garg, Abhishek D.; Smeets, Ann; Lambrechts, Diether; Biganzoli, Elia; Richard, François; Desmedt, Christine (Journal article; Peer reviewed, 2023)
      Obesity is associated with an increased risk of developing breast cancer (BC) and worse prognosis in BC patients, yet its impact on BC biology remains understudied in humans. This study investigates how the biology of ...

    • Asthma, atopy, and lung function in young adults after hospitalization for bronchiolitis in infancy 

      Sørensen, Karen Galta (Doctoral thesis, 2023-10-06)
      Bakgrunn: Bronkiolitt er en viral nedre luftveisinfeksjon som ofte rammer spedbarn. Respiratorisk syncytialt virus er det vanligste viruset ved bronkiolitt, etterfulgt av rhinovirus. Bronkiolitt er assosiert med økt risiko ...

    • Blood eosinophils during bronchiolitis: Associations with atopy, asthma and lung function in young adults 

      Sørensen, Karen Galta; Øymar, Knut Asbjørn Alexander; Dalen, Ingvild; Halvorsen, Thomas; Mikalsen, Ingvild Bruun (Journal article; Peer reviewed, 2023)
      Aim: To study if blood eosinophils during bronchiolitis were associated with atopy, asthma and lung function in young adults and if these associations differed between respiratory syncytial virus (RSV) bronchiolitis and ...

    • Accelerometry May be Superior to EMG for Early Evaluation of Vocal Cord Function After Nerve Injury in a Pig Model 

      Setså, Erling Johan; Svendsen, Øyvind Sverre; Henriksen, Bård; Stangeland, Lodve; Husby, Paul; Brauckhoff, Katrin (Journal article; Peer reviewed, 2023)
      Objective Vocal cord (VC) movement has been demonstrated by the use of accelerometry (ACC) to decrease in parallel with the electromyographic amplitude (EMG) during ongoing traction injury to the recurrent laryngeal nerve ...

    • Preoperative CA125 Significantly Improves Risk Stratification in High-Grade Endometrial Cancer 

      Lombaers, Marike S.; Cornel, Karlijn M. C.; Visser, Nicole C. M.; Bulten, Johan; Küsters-Vandevelde, Heidi V. N.; Amant, Frédéric; Boll, Dorry; Bronsert, Peter; Colas, Eva; Geomini, Peggy M. A. J.; Gil-Moreno, Antonio; van Hamont, Dennis; Huvila, Jutta; Krakstad, Camilla; Kraayenbrink, Arjan A.; Koskas, Martin; Mancebo, Gemma; Matías-Guiu, Xavier; Ngo, Huy; Pijlman, Brenda M.; Vos, Maria Caroline; Weinberger, Vit; Snijders, Marc P. L. M.; van Koeverden, Sebastiaan W.; Haldorsen, Ingfrid S.; Reijnen, Casper; Pijnenborg, Johanna M. A. (Journal article; Peer reviewed, 2023)
      Patients with high-grade endometrial carcinoma (EC) have an increased risk of tumor spread and lymph node metastasis (LNM). Preoperative imaging and CA125 can be used in work-up. As data on cancer antigen 125 (CA125) in ...

    • Genome-wide analysis of anorexia nervosa and major psychiatric disorders and related traits reveals genetic overlap and identifies novel risk loci for anorexia nervosa 

      Bang, Lasse; Bahrami, Shahram; Hindley, Guy; Smeland, Olav Bjerkehagen; Rødevand, Linn; Jaholkowski, Piotr Pawel; Shadrin, Alexey; O'Connell, Kevin Sean; Frei, Oleksandr; Lin, Aihua; Rahman, Zillur; Cheng, Weiqiu; Parker, Nadine; Fan, Chun C.; Dale, Anders M.; Djurovic, Srdjan; Bulik, Cynthia M.; Andreassen, Ole (Journal article; Peer reviewed, 2023)
      Anorexia nervosa (AN) is a heritable eating disorder (50–60%) with an array of commonly comorbid psychiatric disorders and related traits. Although significant genetic correlations between AN and psychiatric disorders and ...

    • Urinary Marker Profiles in Heart Failure with Reduced Versus Preserved Ejection Fraction 

      Streng, Koen W.; Hillege, Hans L.; ter Maaten, Jozine M.; van Veldhuisen, Dirk J.; Dickstein, Kenneth; Samani, Nilesh J.; Ng, Leong L.; Metra, Marco; Filippatos, Gerasimos S.; Ponikowski, Piotr; Zannad, Faiez; Anker, Stefan D.; van der Meer, Peter; Lang, Chim C.; Voors, Adriaan A.; Damman, Kevin (Journal article; Peer reviewed, 2023)
      Background Recent data suggest different causes of renal dysfunction between heart failure with reduced (HFrEF) versus preserved ejection fraction (HFpEF). We therefore studied a wide range of urinary markers reflecting ...

    • Dominant-negative heterozygous mutations in AIRE confer diverse autoimmune phenotypes 

      Oftedal, Bergithe Eikeland; Assing, Kristian; Baris, Safa; Safgren, Stephanie L.; Johansen, Isik S.; Jakobsen, Marianne Antonius; Babovic-Vuksanovic, Dusica; Agre, Katherine; Klee, Eric W.; Majcic, Emina; Ferré, Elise M.N.; Schmitt, Monica M.; DiMaggio, Tom; Rosen, Lindsey B.; Rahman, Muhammad; Chrysis, Dionisios; Giannakopoulos, Aristeidis; Garcia, Maria Tallon; González-Granado, Luis Ignacio; Stanley, Katherine; Galant-Swafford, Jessica; Suwannarat, Pim; Meyts, Isabelle; Lionakis, Michail S.; Husebye, Eystein Sverre (Journal article; Peer reviewed, 2023)
      Autoimmune polyendocrine syndrome type 1 (APS-1) is an autosomal recessive disease characterized by severe and childhood onset organ-specific autoimmunity caused by mutations in the autoimmune regulator (AIRE) gene. More ...

    • How, not if, is the question mycologists should be asking about DNA-based typification 

      Nilsson, R. Henrik; Ryberg, Martin; Wurzbacher, Christian; Tedersoo, Leho; Anslan, Sten; Põlme, Sergei; Spirin, Viacheslav; Mikryukov, Vladimir; Svantesson, Sten; Hartmann, Martin; Lennartsdotter, Charlotte; Belford, Pauline; Khomich, Maryia; Retter, Alice; Corcoll, Natàlia; Martinez, Daniela Gómez; Jansson, Tobias; Ghobad-Nejhad, Masoomeh; Vu, Duong; Sanchez-Garcia, Marisol; Kristiansson, Erik; Abarenkov, Kessy (Journal article; Peer reviewed, 2023)
      Fungal metabarcoding of substrates such as soil, wood, and water is uncovering an unprecedented number of fungal species that do not seem to produce tangible morphological structures and that defy our best attempts at ...

    • Identification and characterization of aptameric inhibitors of human neutrophil elastase 

      Malicki, Stanisław; Książek, Mirosław; Sochaj Gregorczyk, Alicja; Kaminska, Marta; Golda, Anna; Chruścicka, Barbara; Mizgalska, Danuta; Potempa, Jan; Marti, Hans Peter; Kozieł, Joanna; Wieczorek, Maciej; Pieczykolan, Jerzy; Mydel, Piotr Mateusz; Dubin, Grzegorz (Journal article; Peer reviewed, 2023)
      Human neutrophil elastase (HNE) plays a pivotal role in innate immunity, inflammation, and tissue remodeling. Aberrant proteolytic activity of HNE contributes to organ destruction in various chronic inflammatory diseases ...

    • A worldwide survey on incidence, management, and prognosis of oesophageal fistula formation following atrial fibrillation catheter ablation: The POTTER-AF study 

      Tilz, Roland Richard; Schmidt, Vanessa; Pürerfellner, Helmut; Maury, Philippe; Julian Chun, Chun; Martinek, Martin; Sohns, Christian; Schmidt, Boris; Mandel, Franck; Gandjbakhch, Estelle; Laredo, Mikael; Gunawardene, Melanie Anuscha; Willems, Stephan; Beiert, Thomas; Borlich, Martin; Iden, Leon; Füting, Anna; Spittler, Raphael; Gaspar, Thomas; Richter, Sergio; Schade, Anja; Kuniss, Malte; Neumann, Thomas; Francke, Alexander; Wunderlich, Carsten; Shin, Dong-In; Meininghaus, Dirk Grosse; Foresti, Mike; Bonsels, Marc; Reek, David; Wiegand, Uwe; Bauer, Alexander; Metzner, Andreas; Eckardt, Lars; Popescu, Sorin Stefan; Krahnefeld, Olaf; Sticherling, Christian; Kühne, Michael; Nguyen, Dinh Quang; Roten, Laurent; Saguner, Ardan M; Linz, Dominik; Van Der Voort, Pepijn; Mulder, Bart A; Vijgen, Johan; Almorad, Alexandre; Guenancia, Charles; Fauchier, Laurent; Boveda, Serge; Greef, Y. De; Da Costa, Antoine; Jais, Pierre; Derval, Nicolas; Milhem, Antoine; Jesel, Laurence; Garcia, Rodrigue; Poty, Hervé; Khoueiry, Ziad; Seitz, Julien; Laborderie, Julien; Mechulan, Alexis; Brigadeau, Francois; Zhao, Alexandre; Saludas, Yannick; Piot, Olivier; Ahluwalia, Nikhil; Martin, Claire; Chen, Jian; Antolic, Bor; Leventopoulos, Georgios; Özcan, Emin Evren; Yorgun, Hikmet; Cay, Serkan; Yalin, Kivanc; Botros, Maichel Sobhy; Mahmoud, Ahmed Taher; Jȩdrzejczyk-Patej, Ewa; Inaba, Osamu; Okumura, Ken; Ejima, Koichiro; Khakpour, Houman; Boyle, Noel; Catanzaro, John N; Reddy, Vivek; Mohanty, Sanghamitra; Natale, Andrea; Blessberger, Hermann; Yang, Bing; Stevens, Irene; Sommer, Philipp; Veltmann, Christian; Steven, Daniel; Vogler, Julia; Kuck, Karl-Heinz; Merino, José Luis; Keelani, Ahmad; Heeger, Christian-H (Journal article; Peer reviewed, 2023)
      Aims Oesophageal fistula represents a rare but dreadful complication of atrial fibrillation catheter ablation. Data on its incidence, management, and outcome are sparse. Methods and results This international multicentre ...

    • Genetics of diabetes-associated microvascular complications 

      Lyssenko, Valeriya; Vaag, Allan (Journal article; Peer reviewed, 2023)
      Diabetes is associated with excess morbidity and mortality due to both micro- and macrovascular complications, as well as a range of non-classical comorbidities. Diabetes-associated microvascular complications are those ...

    • Spatiotemporal variation in risk of Shigella infection in childhood: a global risk mapping and prediction model using individual participant data 

      Badr, Hamada S; Colston, Josh M; Nguyen, Nhat-Lan H; Chen, Yen Ting; Burnett, Eleanor; Ali, Syed Asad; Rayamajhi, Ajit; Satter, Syed M; Van Trang, Nguyen; Eibach, Daniel; Krumkamp, Ralf; May, Jürgen; Adegnika, Ayola Akim; Manouana, Gédéon Prince; Kremsner, Peter Gottfried; Chilengi, Roma; Hatyoka, Luiza; Debes, Amanda K; Ateudjieu, Jerome; Faruque, Abu S G; Hossain, M Jahangir; Kanungo, Suman; Kotloff, Karen L; Mandomando, Inácio; Nisar, M Imran; Omore, Richard; Sow, Samba O; Zaidi, Anita K M; Lambrecht, Nathalie; Adu, Bright; Page, Nicola; Platts-Mills, James A; Mavacala Freitas, Cesar; Pelkonen, Tuula; Ashorn, Per; Maleta, Kenneth; Ahmed, Tahmeed; Bessong, Pascal; Bhutta, Zulfiqar A; Mason, Carl; Mduma, Estomih; Olortegui, Maribel P; Peñataro Yori, Pablo; Lima, Aldo A M; Kang, Gagandeep; Humphrey, Jean; Ntozini, Robert; Prendergast, Andrew J; Okada, Kazuhisa; Wongboot, Warawan; Langeland, Nina; Moyo, Sabrina John; Gaensbauer, James; Melgar, Mario; Freeman, Matthew; Chard, Anna N; Thongpaseuth, Vonethalom; Houpt, Eric; Zaitchik, Benjamin F; Kosek, Margaret N (Journal article; Peer reviewed, 2023)
      Background Diarrhoeal disease is a leading cause of childhood illness and death globally, and Shigella is a major aetiological contributor for which a vaccine might soon be available. The primary objective of this study ...

    • Human gain-of-function variants in HNF1A confer protection from diabetes but independently increase hepatic secretion of atherogenic lipoproteins 

      DeForest, Natalie; Kavitha, Babu; Hu, Siqi; Isaac, Roi; Krohn, Lynne; Wang, Minxian; Du, Xiaomi; De Arruda Saldanha, Camila; Gylys, Jenny; Merli, Edoardo; Abagyan, Ruben; Najmi, Laeya Abdoli; Mohan, Viswanathan; Flannick, Jason; Peloso, Gina M.; Gordts, Philip L.S.M.; Heinz, Sven; Deaton, Aimee M.; Khera, Amit V.; Olefsky, Jerrold; Radha, Venkatesan; Majithia, Amit R. (Journal article; Peer reviewed, 2023)
      Loss-of-function mutations in hepatocyte nuclear factor 1A (HNF1A) are known to cause rare forms of diabetes and alter hepatic physiology through unclear mechanisms. In the general population, 1:100 individuals carry a ...

    • Ca-EDTA restores the activity of ceftazidime-avibactam or aztreonam against carbapenemase-producing Klebsiella pneumoniae infections 

      Wannigama, Dhammika Leshan; Sithu Shein, Aye Mya; Hurst, Cameron; Monk, Peter N.; Hongsing, Parichart; Phattharapornjaroen, Phatthranit; Fox Ditcham, William Graham; Ounjai, Puey; Saethang, Thammakorn; Chantaravisoot, Naphat; Wapeesittipan, Pattama; Luk-in, Sirirat; Sae-Joo, Sasipen; Nilgate, Sumanee; Rirerm, Ubolrat; Tanasatitchai, Chanikan; Kueakulpattana, Naris; Laowansiri, Matchima; Liao, Tingting; Kupwiwat, Rosalyn; Rojanathanes, Rojrit; Ngamwongsatit, Natharin; Tungsanga, Somkanya; Leelahavanichkul, Asada; Devanga Ragupathi, Naveen Kumar; Badavath, Vishnu Nayak; Hosseini Rad, S.M. Ali; Kanjanabuch, Talerngsak; Hirankarn, Nattiya; Storer, Robin James; Cui, Longzhu; Amarasiri, Mohan; Ishikawa, Hitoshi; Higgins, Paul G.; Stick, Stephen M.; Kicic, Anthony; Chatsuwan, Tanittha; Abe, Shuichi (Journal article; Peer reviewed, 2023)
      Developing an effective therapy to overcome carbapenemase-positive Klebsiella pneumoniae (CPKp) is an important therapeutic challenge that must be addressed urgently. Here, we explored a Ca-EDTA combination with aztreonam ...

    • B-vitamin Treatment Modifies the Mortality Risk Associated with Calcium Channel Blockers in Patients with Suspected Stable Angina Pectoris: A Prospective Cohort Study 

      Dhar, Indu; Svingen, Gard Frodahl Tveitevåg; Bjørnestad, Espen Øglænd; Ulvik, Arve; Saeed, Sahrai; Nygård, Ottar Kjell (Journal article; Peer reviewed, 2023)
      Background Calcium channel blockers (CCBs) are used for the treatment of cardiovascular disease (CVD), including angina pectoris, and hypertension; however, the effect on survival remains uncertain. CCBs impair fibrinolysis ...

    • Magnetic Resonance Imaging and Computed Tomography for the Noninvasive Assessment of Arterial Aging: A Review by the VascAgeNet COST Action 

      Bianchini, Elisabetta; Lønnebakken, Mai Tone; Wohlfahrt, Peter; Piskin, Senol; Terentes-Printzios, Dimitrios; Alastruey, Jordi; Guala, Andrea (Journal article; Peer reviewed, 2023)
      Magnetic resonance imaging and computed tomography allow the characterization of arterial state and function with high confidence and thus play a key role in the understanding of arterial aging and its translation into the ...

    • Modulation of Unfolded Protein Response Restores Survival and Function of β-Cells Exposed to the Endocrine Disruptor Bisphenol A 

      Daian, Laura Maria; Tanko, Gabriela; Vacaru, Andrei Mircea; Ghila, Luiza Mihaela; Chera, Simona; Vacaru, Ana-Maria (Journal article; Peer reviewed, 2023-01-19)
      Diabetes is a metabolic disease that currently affects nearly half a billion people worldwide. β-cells dysfunction is one of the main causes of diabetes. Exposure to endocrine-disrupting chemicals is correlated with increased ...

    • Healthy Nordic diet and associations with plasma concentrations of metabolites in the choline oxidation pathway: a cross-sectional study from Northern Sweden 

      Hesselink, André; Winkvist, Anna; Lindahl, Bernt; Ueland, Per Magne; Schneede, Jørn; Johansson, Ingegerd; Karlsson, Therese (Journal article; Peer reviewed, 2023-05-17)
      Background: The choline oxidation pathway and metabolites involved have been linked to diseases including cardiovascular disease, type 2 diabetes and cancer. A healthy Nordic diet is a recently defined dietary pattern ...

    • Hepcidin analysis in pneumonia: Comparison of immunoassay and LC-MS/MS 

      Oppen, Kjersti; Brede, Cato; Skadberg, Øyvind; Steinsvik, Trude; Holter, Jan Cato; Michelsen, Annika Elisabet; Heggelund, Lars (Journal article; Peer reviewed, 2023)
      Background: The iron-regulatory hormone hepcidin is a promising biomarker to differentiate anaemia of inflammation from iron deficiency. Plasma hepcidin concentrations increase substantially during inflammation, and the ...