Department of Clinical Science: Nye registreringer

Viser treff 361-380 av 2318

    • Kidney complications and hospitalization in patients with chronic hypoparathyroidism: A cohort study in Sweden 

      Swartling, Oskar; Evans, Marie; Spelman, Tim; Kamal, Wafa; Kämpe, Olle; Mannstadt, Michael; Trolle Lagerros, Ylva; Björnsdottir, Sigridur (Journal article; Peer reviewed, 2022)
      Context: Kidney complications may be considerably higher in patients with chronic hypoparathyroidism (hypoPT) treated with activated vitamin D and calcium supplementation. Objective: We aimed to investigate the risk of ...

    • Effects of estradiol- and ethinylestradiol-based contraceptives on adrenal steroids: A randomized trial 

      Kangasniemi, Marika H; Arffman, Riikka K; Haverinen, Annina; Luiro, Kaisu; Hustad, Simon Steinar; Heikinheimo, Oskari; Tapanainen, Juha S; Piltonen, Terhi T (Journal article; Peer reviewed, 2022)
      Objectives: Ethinylestradiol (EE)-based combined oral contraceptives (COC) affect adrenal function by altering steroid and corticosteroid-binding globulin (CBG) synthesis that may contribute to adverse effects related to ...

    • Serum or Plasma for Quantification of Direct Oral Anticoagulants? 

      Aakerøy, Rachel; Stokes, Charlotte Lorentze; Tomic, Marija; Hegstad, Solfrid; Kristoffersen, Ann-Helen; Ellekjær, Hanne; Schjøtt, Jan Didrik; Spigset, Olav; Helland, Arne (Journal article; Peer reviewed, 2022)
      Background: Direct oral anticoagulants are increasingly replacing vitamin K antagonists for prevention of stroke in patients with atrial fibrillation, partly owing to the lack of a need for routine monitoring. Therapeutic ...

    • Vaccination rates in Europe are not associated with online media intensity 

      Luís, Catarina; Di Marzo, Verónica Romina; Kaur, Mandeep; Argyropoulos, Christos D.; Devane, Declan; Stewart, Fiona A.; Antoniou, George; Hendrickx, Greet; Askling, Helena Hervius; Hellemans, Margot; Cohen, Miriam; Spivak, Orly; Damme, Pierre Van; Cox, Rebecca Jane; Vene, Sirkka; Sibia, Sofie; Pana, Zoi Dorothea; Olesen, Ole F. (Journal article; Peer reviewed, 2022)
      To map the public information about COVID-19 vaccines and vaccine trials in Europe, we have compiled an inventory of online communication materials from official sources (e.g., governments, public agencies, and NGOs) via ...

    • Updated total IgE reference intervals in Norwegian adults 

      Vinnes, Erik Wilhelm; Skarbø, Birthe Rochlenge Skarbø; Wentzel-Larsen, Tore; Sylte, Marit Sverresdotter; Apelseth, Torunn Oveland (Journal article; Peer reviewed, 2023)
      Background It is important and expected of laboratories to provide updated reference intervals to the clinician. As no recent publications report adult total IgE reference intervals on a Scandinavian population, the aim ...

    • Mutational Signature 3 Detected from Clinical Panel Sequencing is Associated with Responses to Olaparib in Breast and Ovarian Cancers 

      Batalini, Felipe; Gulhan, Doga C.; Mao, Victor; Tran, Antuan; Polak, Madeline; Xiong, Niya; Tayob, Nabihah; Tung, Nadine M.; Winer, Eric P.; Mayer, Erica L.; Knappskog, Stian; Lønning, Per Eystein; Matulonis, Ursula A.; Konstantinopoulos, Panagiotis A.; Solit, David B.; Won, Helen; Eikesdal, Hans Petter; Park, Peter J.; Wulf, Gerburg M. (Journal article; Peer reviewed, 2022)
      Purpose: The identification of patients with homologous recombination deficiency (HRD) beyond BRCA1/2 mutations is an urgent task, as they may benefit from PARP inhibitors. We have previously developed a method to detect ...

    • Histologic healing and factors associated with complete remission following conventional treatment in ulcerative colitis 

      Steinsbø, Øyvind; Carlsen, Arne; Aasprong, Ole Gunnar; Aabakken, Lars; Tvedt-Gundersen, Espen; Bjørkhaug, Steinar Traae; Gjerde, Rune; Karlsen, Lars Normann; Grimstad, Tore Bjørn (Journal article; Peer reviewed, 2022)
      Background: Endoscopic and histological activity scores in ulcerative colitis (UC) are associated with clinical outcomes and have become important targets of clinical trials. However, these endpoints have been scarcely ...

    • Pathway‑level mutation analysis in primary high‑grade serous ovarian cancer and matched brain metastases 

      Duchnowska, Renata; Supernat, Anna Maria; Pęksa, Rafał; Łukasiewicz, Marta; Stokowy, Tomasz; Ronen, Roy; Dutkowski, Janusz; Umińska, Monika; Iżycka-Świeszewska, Ewa; Kowalczyk, Anna; Och, Waldemar; Rucińska, Monika; Olszewski, Wojciech P.; Mandat, Tomasz; Jarosz, Bożena; Bieńkowski, Michał; Biernat, Wojciech; Jassem, Jacek (Journal article; Peer reviewed, 2022)
      Brain metastases (BMs) in ovarian cancer (OC) are a rare event. BMs occur most frequently in high-grade serous (HGS) OC. The molecular features of BMs in HGSOC are poorly understood. We performed a whole-exome sequencing ...

    • Improving pharmaceutical care for patients with Chronic Obstructive Pulmonary Disease. A survey on patient experiences and preferences concerning disease management interventions. 

      Eldholm, Helen (Master thesis, 2022-11-21)

    • The lower airways microbiota and antimicrobial peptides indicate dysbiosis in sarcoidosis 

      Knudsen, Kristel Svalland; Lehmann, Sverre; Nielsen, Rune; Tangedal, Solveig; Paytuví-Gallart, Andreu; Sanseverino, Walter; Martinsen, Einar Marius Hjellestad; Hiemstra, Pieter S.; Eagan, Tomas Mikal Lind (Journal article; Peer reviewed, 2022-10-19)
      Background: The role of the pulmonary microbiome in sarcoidosis is unknown. The objectives of this study were the following: (1) examine whether the pulmonary fungal and bacterial microbiota differed in patients with ...

    • Whole-genome sequencing identifies new candidate genes for nonobstructive azoospermia 

      Malcher, Agnieszka; Stokowy, Tomasz; Berman, Andrea; Olszewska, Marta; Jedrzejczak, Piotr; Sielski, Dawid; Nowakowski, Adam; Rozwadowska, Natalia; Yatsenko, Alexander N.; Kurpisz, Maciej K. (Journal article; Peer reviewed, 2022)
      Background: Genetic causes that lead to spermatogenetic failure in patients with nonobstructive azoospermia (NOA) have not been yet completely established. Objective: To identify low-frequency NOA-associated single ...

    • Respiratory symptoms and cardiovascular causes of deaths: A population-based study with 45 years of follow-up 

      Stavem, Knut; Schirmer, Henrik; Gulsvik, Amund (Journal article; Peer reviewed, 2022)
      This study determined the association between respiratory symptoms and death from cardiovascular (CV) diseases during 45 years in a pooled sample of four cohorts of random samples of the Norwegian population with 95,704 ...

    • IFN-α with dasatinib broadens the immune repertoire in patients with chronic-phase chronic myeloid leukemia 

      Huuhtanen, Jani; Ilander, Mette; Yadav, Bhagwan; Dufva, Olli M.J.; Lähteenmäki, Hanna; Kasanen, Tiina; Klievink, Jay; Olsson-Strömberg, Ulla; Stentoft, Jesper; Richter, Johan; Koskenvesa, Perttu; Höglund, Martin; Söderlund, Stina; Dreimane, Arta; Porkka, Kimmo; Gedde-Dahl, Tobias; Gjertsen, Bjørn Tore; Stenke, Leif; Myhr-Eriksson, Kristina; Markevärn, Berit; Lübking, Anna; Dimitrijevic, Andreja; Udby, Lene; Bjerrum, Ole Weis; Hjorth-Hansen, Henrik; Mustjoki, Satu (Journal article; Peer reviewed, 2022)
      In chronic myeloid leukemia (CML), combination therapies with tyrosine kinase inhibitors (TKIs) aim to improve the achievement of deep molecular remission that would allow therapy discontinuation. IFN-α is one promising ...

    • A Systematic Review of the Current Evidence from Randomised Controlled Trials on the Impact of Medication Optimisation or Pharmacological Interventions on Quantitative Measures of Cognitive Function in Geriatric Patients 

      Pazan, Farhad; Petrovic, Mirko; Cherubini, Antonio; Cruz-Jentoft, Alfonso J.; Denkinger, Michael; van der Cammen, Tischa J. M.; Stevenson, Jennifer M.; Ibrahim, Kinda; Rajkumar, Chakravarthi; Bakken, Marit Stordal; Crome, Peter; Guðmundsson, Adalsteinn; Knol, Wilma; Snijders, Birgitta M. G.; O’Mahony, Denis; Serra-Rexach, José Antonio; Soulis, George; van Marum, Rob J.; Ziere, Gijsbertus; Mair, Alpana; Burkhardt, Heinrich; Neumann-Podczaska, Agnieszka; Wieczorowska-Tobis, Katarzyna; Fernandes, Marilia Andreia; Gruner, Heidi; van der Velde, Nathalie; Wehling, Martin (Journal article; Peer reviewed, 2022)
      Background Cognitive decline is common in older people. Numerous studies point to the detrimental impact of polypharmacy and inappropriate medication on older people’s cognitive function. Here we aim to systematically ...

    • Short-term safety of COVID-19 mRNA vaccines with respect to all-cause mortality in the older population in Norway 

      Lopez-Doriga Ruiz, Paz; Gunnes, Nina; Gran, Jon Michael; Karlstad, Øystein; Selmer, Randi Marie; Dahl, Jesper; Bøås, Håkon; White, Richard Aubrey; Hofman, Aurora Christine; Paulsen, Trine Hessevik; Watle, Sara Sofie Viksmoen; Ranhoff, Anette Hylen; Bukholm, Geir; Gulseth, Hanne Løvdal; Tapia, German (Journal article; Peer reviewed, 2022)
      Background There have been concerns about COVID-19 vaccination safety among frail older individuals. We investigated the relationship between COVID-19 mRNA vaccination and mortality among individuals aged ≥ 70 years and ...

    • Respiratory Health in Cleaners in Northern Europe: Is Susceptibility Established in Early Life? 

      Svanes, Øistein; Skorge, Trude Duelien; Johannessen, Ane; Bertelsen, Randi Jacobsen; Bråtveit, Magne; Forsberg, Bertil; Gislason, Thorarin; Holm, Mathias; Janson, Christer; Jögi, Rain; Macsali, Ferenc; Norbäck, Dan; Omenaas, Ernst; Gomez Real, Francisco; Schlünssen, Vivi; Sigsgaard, Torben; Wieslander, Gunilla; Zock, Jan-Paul; Aasen, Tor Olav Brøvig; Dratva, Julia; Svanes, Cecilie (Journal article; Peer reviewed, 2015)
      Rationale There is some evidence that maternal smoking increases susceptibility to personal smoking’s detrimental effects. One might question whether early life disadvantage might influence susceptibility to occupational ...

    • Distinct T cell subsets in adipose tissue are associated with obesity 

      Haugstøyl, Martha Eimstad; Cornillet, Martin; Strand, Kristina; Stiglund, Natalie; Sun, Dan; Lawrence-Archer, Laurence; Hjellestad, Iren Drange; Sparrelid, Ernesto; Busch, Christian; Hjelmesæth, Jøran Sture; Hertel, Jens Kristoffer; Ponzetta, Andrea; Mellgren, Gunnar; Fernø, Johan; Björkström, Niklas K. (Journal article; Peer reviewed, 2022)
      Adipose tissue inflammation is a driving factor for the development of obesity-associated metabolic disturbances, and a role of adipose tissue T cells in initiating the pro-inflammatory signaling is emerging. However, data ...

    • Recommendations for robust and reproducible preclinical research in personalised medicine 

      Fosse, Vibeke Samuelsen; Oldoni, Emanuela; Bietrix, Florence; Budillon, Alfredo; Daskalopoulos, Evnagelos P.; Fratelli, Maddalena; Gerlach, Björn; Groenen, Peter M.A.; Hölter, Sabine M.; Menon, Julia M.L.; Mobasheri, Ali; Osborne, Nikki; Ritskes-Hoitinga, Merel; Ryll, Bettina; Schmitt, Elmar; Ussi, Anton; Andreu, Antonio L.; Mccormack, Emmet Matin (Journal article; Peer reviewed, 2023)
      Background Personalised medicine is a medical model that aims to provide tailor-made prevention and treatment strategies for defined groups of individuals. The concept brings new challenges to the translational step, both ...

    • A Simple Cervicovaginal Epigenetic Test for Screening and Rapid Triage of Women With Suspected Endometrial Cancer: Validation in Several Cohort and Case/Control Sets 

      Herzog, Chiara; Marín, Fátima; Jones, Allison; Evans, Iona; Reisel, Daniel; Redl, Elisa; Schreiberhuber, Lena; Paytubi, Sonia; Pelegrina, Beatriz; Carmona, Álvaro; Peremiquel-Trillas, Paula; Frias-Gomez, Jon; Pineda, Marta; Brunet, Joan; Ponce, Jordi; Matias-Guiu, Xavier; de Sanjosé, Silvia; Alemany, Laia; Olaitan, Adeola; Wong, Michael; Jurkovic, Davor; Crosbie, Emma J.; Rosenthal, Adam N.; Bjørge, Line; Zikan, Michal; Dostalek, Lukas; Cibula, David; Sundström, Karin; Dillner, Joakim; Costas, Laura; Widschwendter, Martin (Journal article; Peer reviewed, 2022)
      PURPOSE Endometrial cancer (EC) incidence has been rising over the past 10 years. Delays in diagnosis reduce survival and necessitate more aggressive treatment. We aimed to develop and validate a simple, noninvasive, and ...

    • Integrated analysis of cervical squamous cell carcinoma cohorts from three continents reveals conserved subtypes of prognostic significance 

      Chakravarthy, Ankur; Reddin, Ian; Henderson, Stephen; Dong, Cindy; Kirkwood, Nerissa; Jeyakumar, Maxmilan; Rodriguez, Daniela Rothschild; Martinez, Natalia Gonzalez; McDermott, Jacqueline; Su, Xiaoping; Egawa, Nagayasau; Fjeldbo, Christina Sæten; Skingen, Vilde Eide; Lyng, Heidi; Halle, Mari Kyllesø; Krakstad, Camilla; Soleiman, Afschin; Sprung, Susanne; Lechner, Matt; Ellis, Peter J. I.; Wass, Mark; Michaelis, Martin; Fiegl, Heidi; Salvesen, Helga; Thomas, Gareth J.; Doorbar, John; Chester, Kerry; Feber, Andrew; Fenton, Tim R. (Journal article; Peer reviewed, 2022)
      Human papillomavirus (HPV)-associated cervical cancer is a leading cause of cancer deaths in women. Here we present an integrated multi-omic analysis of 643 cervical squamous cell carcinomas (CSCC, the most common histological ...