Department of Clinical Science: Nye registreringer

Viser treff 101-120 av 2318

    • The lower airway microbiota and inflammation in chronic obstructive pulmonary disease (COPD) : Thoughts on where to measure it, how to interpret it, and why it might matter 

      Tangedal, Solveig (Doctoral thesis, 2024-02-01)
      Bakgrunn: Kronisk obstruktiv lungesjukdom (KOLS) er ein kompleks, inflammatorisk sjukdom som forårsakar millionar av dødsfall årleg. Bakteriane i dei nedre luftvegane (mikrobiotaet) og immunresponsar kan spele ei viktig ...

    • Impact of Inititing Biologics in Patients With Severe Asthma on Long-term Oral Corticosteroids or Frequent Rescue Steroids (GLITTER): Data From the International Severe Asthma Registry 

      Chen, Wenjia; Tran, Trung N.; Sadatsafavi, Mohsen; Murray, Ruth; Wong, Nigel Chong Boon; Ali, Nasloon; Ariti, Con; Bulathsinhala, Lakmini; Gil, Esther Garcia; FitzGerald, J. Mark; Alacqua, Marianna; Al-Ahmad, Mona; Altraja, Alan; Al-Lehebi, Riyad; Bhutani, Mohit; Bjermer, Leif Hilding; Bjerrum, Anne-Sofie; Bourdin, Arnaud; von Bülow, Anna; Busby, John; Canonica, Giorgio Walter; Carter, Victoria; Christoff, George C.; Cosio, Borja G.; Costello, Richard W.; Fonseca, João A.; Gibson, Peter G.; Yoo, Kwang-Ha; Heaney, Liam G.; Heffler, Enrico; Hew, Mark; Hilberg, Ole; Hoyte, Flavia; Iwanaga, Takashi; Jackson, David J.; Jones, Rupert C.; Koh, Mariko Siyue; Kuna, Piotr; Larenas-Linnemann, Désirée; Lehmann, Sverre; Lehtimäki, Lauri; Lyu, Juntao; Mahboub, Bassam; Maspero, Jorge; Menzies-Gow, Andrew N.; Newell, Anthony; Sirena, Concetta; Papadopoulos, Nikolaos G.; Papaioannou, Andriana I.; Perez-de-Llano, Luis; Perng (Steve), Diahn-Warng; Peters, Matthew; Pfeffer, Paul E.; Porsbjerg, Celeste M.; Popov, Todor A.; Rhee, Chin Kook; Salvi, Sundeep; Taillé, Camille; Taube, Christian; Torres-Duque, Carlos A.; Ulrik, Charlotte; Ra, Seung-Won; Wang, Eileen; Wechsler, Michael E.; Price, David B. (Journal article; Peer reviewed, 2023)
      Background Effectiveness of biologics has neither been established in patients with high oral corticosteroid exposure (HOCS) nor been compared with effectiveness of continuing with HOCS alone. Objective To examine ...

    • Interplay between human STING genotype and bacterial NADase activity regulates inter-individual disease variability 

      Movert, Elin; Bolarin, Jaume Salgado; Valfridsson, Christine; Velarde, Jorge; Skrede, Steinar; Nekludov, Michael; Hyldegaard, Ole; Arnell, Per; Svensson, Mattias; Norrby-Teglund, Anna; Cho, Kyu Hong; Elhaik, Eran; Wessels, Michael R.; Råberg, Lars; Carlsson, Fredric (Journal article; Peer reviewed, 2023)
      Variability in disease severity caused by a microbial pathogen is impacted by each infection representing a unique combination of host and pathogen genomes. Here, we show that the outcome of invasive Streptococcus pyogenes ...

    • Characterisation of HNF1A variants in paediatric diabetes in Norway using functional and clinical investigations to unmask phenotype and monogenic diabetes 

      Svalastoga, Pernille; Kaci, Alba; Molnes, Janne; Solheim, Marie Holm; Johansson, Bente Berg; Krogvold, Lars; Skrivarhaug, Torild; Valen, Eivind; Johansson, Stefan; Molven, Anders; Sagen, Jørn Vegard; Søfteland, Eirik; Bjørkhaug, Lise; Tjora, Erling; Aukrust, Ingvild; Njølstad, Pål Rasmus (Journal article; Peer reviewed, 2023)
      Aims/hypothesis Correctly diagnosing MODY is important, as individuals with this diagnosis can discontinue insulin injections; however, many people are misdiagnosed. We aimed to develop a robust approach for determining ...

    • Fatty Acids Composition and HIV Infection: Altered Levels of n-6 Polyunsaturated Fatty Acids Are Associated with Disease Progression 

      Ueland, Thor; Waagsbø, Bjørn; Berge, Rolf Kristian; Trøseid, Marius; Aukrust, Pål; Damås, Jan Kristian (Journal article; Peer reviewed, 2023)
      Fatty acids (FAs) are important regulators of immune responses and innate defense mechanisms. We hypothesized that disturbed FA metabolism could contribute to the progression of HIV infection. Plasma levels of 45 FAs were ...

    • Impaired Adipocyte SLC7A10 Promotes Lipid Storage in Association With Insulin Resistance and Altered BCAA Metabolism 

      Jersin, Regine Åsen; Tallapragada, Divya Sri; Skartveit, Linn; Bjune, Mona Synnøve; Muniandy, Maheswary; Lee-Ødegård, Sindre; Heinonen, Sini; Alvarez, Marcus; Birkeland, Kåre Inge; Drevon, Christian André; Pajukanta, Päivi; McCann, Adrian; Pietiläinen, Kirsi H.; Claussnitzer, Melina; Mellgren, Gunnar; Dankel, Simon N (Journal article; Peer reviewed, 2023)
      Context The neutral amino acid transporter SLC7A10/ASC-1 is an adipocyte-expressed gene with reduced expression in insulin resistance and obesity. Inhibition of SLC7A10 in adipocytes was shown to increase lipid accumulation ...

    • Fathers’ preconception smoking and offspring DNA methylation 

      Kitaba, Negusse Tadesse; Knudsen, Gerd Toril Mørkve; Johannessen, Ane; Rezwan, Faisal I.; Malinovschi, Andrei; Oudin, Anna; Benediktsdottir, Bryndis; Martino, David; González, Francisco Javier Callejas; Gómez, Leopoldo Palacios; Holm, Mathias; Jögi, Nils Oskar; Dharmage, Shyamali C.; Skulstad, Svein Magne; Watkins, Sarah H.; Suderman, Matthew; Gomez Real, Francisco; Schlünssen, Vivi; Svanes, Cecilie; Holloway, John W. (Journal article; Peer reviewed, 2023)
      Background Experimental studies suggest that exposures may impact respiratory health across generations via epigenetic changes transmitted specifically through male germ cells. Studies in humans are, however, limited. ...

    • Neutrophil-derived reactive agents induce a transient SpeB negative phenotype in Streptococcus pyogenes 

      Shumba, Patience; Sura, Thomas; Moll, Kirsten; Chakrakodi, Bhavya; Tölken, Lea A.; Hoßmann, Jörn; Hoff, Katharina J.; Hyldegaard, Ole; Nekludov, Michael; Svensson, Mattias; Arnell, Per; Skrede, Steinar; Norrby-Teglund, Anna; Siemens, Nikolai (Journal article; Peer reviewed, 2023)
      Background Streptococcus pyogenes (group A streptococci; GAS) is the main causative pathogen of monomicrobial necrotizing soft tissue infections (NSTIs). To resist immuno-clearance, GAS adapt their genetic information ...

    • Nausea Predicts Bacteremia in Immunocompetent Patients with Pneumococcal Community-Acquired Pneumonia: Secondary Data Analysis from a Prospective Cohort 

      Fløystad, Hans Kristian; Holter, Jan Cato; Husebye, Einar; Siljan, William Ward; Berild, Dag; Holm, Are Martin; Heggelund, Lars (Journal article; Peer reviewed, 2023)
      Background: In pneumococcal community-acquired pneumonia (CAP), bacteremia is associated with increased mortality, but initial clinical severity scores frequently fail to identify bacteremic patients at risk. We have ...

    • Pharmacokinetics, Safety, and Tolerability of Imipenem/Cilastatin/Relebactam in Children with Confirmed or Suspected Gram-Negative Bacterial Infections: A Phase 1b, Open-Label, Single-Dose Clinical Trial 

      Bradley, John S; Makieieva, Nataliia; Tøndel, Camilla; Roilides, Emmanuel; Kelly, Matthew S.; Patel, Munjal; Vaddady, Pavan; Maniar, Alok; Zhang, Ying; Paschke, Amanda; Chen, Luke F (Journal article; Peer reviewed, 2023)
      Imipenem/cilastatin/relebactam is approved for the treatment of serious gram-negative bacterial infections in adults. This study assessed the pharmacokinetics (PK), safety, and tolerability of a single dose of imipenem/c ...

    • Dynamics of circulating lymphocytes responding to human experimental enterotoxigenic Escherichia coli infection 

      Rim, Sehee; Sakkestad, Sunniva Todnem; Zhou, Fan; Gullaksen, Stein-Erik; Skavland, Jørn; Chauhan, Sudhir Kumar; Steinsland, Hans; Hanevik, Kurt (Journal article; Peer reviewed, 2023)
      Enterotoxigenic Escherichia coli (ETEC) is an important cause of children's and travelers’ diarrhea, with no licensed vaccine. This study aimed to explore the role of cellular immunity in protection against human ETEC ...

    • Tuberculosis-Associated Hemophagocytic Lymphohistiocytosis: A Review of Current Literature 

      Fauchald, Trym; Blomberg, Bjørn; Reikvam, Håkon (Journal article; Peer reviewed, 2023)
      Hemophagocytic lymphohistiocytosis (HLH) is a condition of immune dysregulation and hyperinflammation, leading to organ failure and death. Malignancy, autoimmune conditions, and infections, including Mycobacterium tuberculosis ...

    • High mobility group box 1 and a network of other biomolecules influence fatigue in patients with Crohn’s disease 

      Kvivik, Ingeborg; Grimstad, Tore Bjørn; Bårdsen, Kjetil; Jonsson, Grete; Kvaløy, Jan Terje; Omdal, Roald (Journal article; Peer reviewed, 2023)
      Background Fatigue is common in patients with chronic inflammatory and autoimmune diseases, often with a severe impact on the patient’s daily life. From a biological point of view, fatigue can be regarded as an element ...

    • Genetic Overlap Between Global Cortical Brain Structure, C-Reactive Protein, and White Blood Cell Counts 

      Parker, Nadine; Cheng, Weiqiu; Hindley, Guy; O'Connell, Kevin Sean; Karthikeyan, Sandeep; Holen, Børge; Shadrin, Alexey; Rahman, Zillur; Karadag, Naz; Bahrami, Shahram; Lin, Aihua; Steen, Nils Eiel; Ueland, Thor; Aukrust, Pål; Djurovic, Srdjan; Dale, Anders; Smeland, Olav Bjerkehagen; Frei, Oleksandr; Andreassen, Ole (Journal article; Peer reviewed, 2024)
      Background For many brain disorders, a subset of patients jointly exhibit alterations in cortical brain structure and elevated levels of circulating immune markers. This may be driven in part by shared genetic architecture. ...

    • Herring roe oil in treatment of psoriasis – influence on immune cells and cytokine network 

      Petrovic, Aleksandra; Bueide, Ingvild Øye; Tveit, Kåre Steinar; Hallaråker, Hogne; Bjørndal, Bodil; Holmes, Timothy Dunstan; Davies, Richard Allan; Brokstad, Karl Albert; Bergum, Brith; Appel, Silke (Journal article; Peer reviewed, 2023)
      Background: Psoriasis is a chronic immune-mediated skin disease with systemic inflammation and comorbidities. Although the disease severity may vary over time, many patients suffer from mild to moderate disease. Often local ...

    • Rekonvalesensplasma mot covid-19 fremstilt fra norske blodgivere 

      Nissen-Meyer, Lise Sofie Haug; Steinsvåg, Christine Torsvik; Fenstad, Mona H.; Sørvoll, Ingvild Hausberg; Hvalryg, Marte; Titze, Thomas Larsen; Magnussen, Karin; Kristoffersen, Gunn; Johnsen, Kathrine M Neuman; LLOHN, ABID HUSSAIN; Hermundstad, Brita; Høiback, Lilja Synnøve; Haugen, Morten; Kristoffersen, Einar Klæboe; Boulland, Line; Kran, Anne-Marte Bakken; Lund-Johansen, Fridtjof; Vaage, John T.; Flesland, Øystein; Hervig, Tor Audun (Journal article; Peer reviewed, 2023)
      BAKGRUNN Ved pandemiens start tok Helsedirektoratet og norske blodbanker initiativ til produksjon av covid-19-rekonvalesensplasma innenfor rammen av kliniske studier. Her beskriver vi blodgiverne som deltok. MATERIALE ...

    • Aerobic high-intensity interval exercise training in patients with angina and no obstructive coronary artery disease: feasibility and physiological effects 

      Larsen, Alf Inge; Sæland, Charlotte; Vegsundvåg, Johnny Åge; Skadberg, Mette Storebø; Nilsen, Jorunn; Butt, Noreen; Ushakova, Anastasia; Valborgland, Torstein; Munk, Peter Scott; Isaksen, Kjetil (Journal article; Peer reviewed, 2023)
      Aims Patients with chest pain and normal coronary angiogram [angina with normal coronary arteries (ANOCA)] constitute a therapeutic problem with considerable functional limitation and reduced quality of life. The aims ...

    • Role of fungal burden in risk stratification of HIV-negative patients with Pneumocystis pneumonia: A 12-year, retrospective, observational, multicenter cohort 

      Grønseth, Stine; Rogne, Tormod; Heggelund, Lars; Åsvold, Bjørn Olav; Afset, Jan Egil; Damås, Jan Kristian (Journal article; Peer reviewed, 2023)
      Objectives This study aimed to explore the role of fungal burden in risk stratification of patients without HIV-negative patients with Pneumocystis pneumonia (PCP). Methods This was a retrospective analysis of the ...

    • New biomarkers in patients with chronic kidney disease, after kidney transplantation, in kidney donors and in acute myocardial infarction 

      Thorsen, Inga Strand (Doctoral thesis, 2024-01-12)
      Nye markører på nyreskade hos nyretransplanterte, nyre donorer, hos pasienter med nyresvikt og hos pasienter med akutt hjerteinfarkt Bakgrunn: Kronisk nyresvikt affiserer mange mennesker. Både insidens og prevalens ...

    • Impaired Lung Function in Extremely Preterm-Born Adults in Their Fourth Decade of Life 

      Bårdsen, Tonje; Røksund, Ola Drange; Eagan, Tomas Mikal Lind; Hufthammer, Karl Ove; Benestad, Merete Røineland; Clemm, Hege Synnøve Havstad; Halvorsen, Thomas; Vollsæter, Maria (Journal article; Peer reviewed, 2023)