Department of Clinical Science: Nye registreringer
Viser treff 161-180 av 2318
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Highly contiguous genomes of human clinical isolates of Giardia duodenalis reveal assemblage-and sub-assemblage-specific presence–absence variation in protein-coding genes
(Journal article; Peer reviewed, 2023)Giardia duodenalis (syn. G. intestinalis, G. lamblia) is a widespread gastrointestinal protozoan parasite with debated taxonomic status. Currently, eight distinct genetic sub-groups, termed assemblages A–H, are defined ... -
Cardiac Function and Early Risk Markers for Cardiovascular Disease in Children and Young Adults Surviving Severe Childhood Disease
(Doctoral thesis, 2023-11-03)Sammendrag på norsk Bakgrunn Prosessene som ligger bak utvikling av hjerte-kar sykdom starter tidlig i livet og er avhengig av antall risikofaktorer og debuttidspunkt av disse. Noen grupper er mer utsatt for hjerte-kar ... -
Revisiting the prognostic role of FLT3 mutations in acute myelogenous leukemia
(Journal article; Peer reviewed, 2023)Introduction: Approximately one-third of patients with acute myelogenous leukemia (AML) harbor mutations in the fms-like tyrosine kinase 3 (FLT3) gene. The features regarding prognostic impact of FLT3 mutated AML have been ... -
Pretransplant systemic metabolic profiles in allogeneic hematopoietic stem cell transplant recipients - identification of patient subsets with increased transplant-related mortality
(Journal article; Peer reviewed, 2023)Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is used in the treatment of high-risk acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS); however, the treatment has high risk of severe ... -
Systemic interferon type I and B cell responses are impaired in autoimmune polyendocrine syndrome type 1
(Journal article; Peer reviewed, 2023)Autoimmune polyendocrine syndrome type I (APS-1) is caused by mutations in the autoimmune regulator (AIRE) gene and characterised clinically by multiple autoimmune manifestations and serologically by autoantibodies against ... -
Single-cell profiling of low-stage endometrial cancers identifies low epithelial vimentin expression as a marker of recurrent disease
(Journal article; Peer reviewed, 2023)Background: Identification of aggressive low-stage endometrial cancers is challenging. So far, studies have failed to pinpoint robust features or biomarkers associated with risk of recurrence for these patients. Methods: ... -
Identification of Cumin (Cuminum cyminum) MicroRNAs through Deep Sequencing and Their Impact on Plant Secondary Metabolism
(Journal article; Peer reviewed, 2023-04-25)The pharmacological properties of plants lie in the content of secondary metabolites that are classified into different categories based on their biosynthesis, structures, and functions. MicroRNAs (miRNAs) are small ... -
The role of inflammation in anxiety and depression in the European U-BIOPRED asthma cohorts
(Journal article; Peer reviewed, 2023)Background: Growing evidence indicates high comorbid anxiety and depression in patients with asthma. However, the mechanisms underlying this comorbid condition remain unclear. The aim of this study was to investigate the ... -
In vitro quality of cold and delayed cold-stored platelet concentrates from interim platelet units during storage for 21 days
(Journal article; Peer reviewed, 2023)Background and Objectives: Based on previous success using apheresis platelets, we wanted to investigate the in vitro quality and platelet function in continuously cold-stored and delayed cold-stored platelet concentrates ... -
Clinical parameters affecting survival outcomes in patients with low-grade serous ovarian carcinoma: An international multicentre analysis
(Journal article; Peer reviewed, 2023)Background: Women with low-grade ovarian serous carcinoma (LGSC) benefit from surgical treatment; however, the role of chemotherapy is controversial. We examined an international database through the Ovarian Cancer Association ... -
Post COVID-19 condition after delta infection and omicron reinfection in children and adolescents
(Journal article; Peer reviewed, 2023)Background: The burden of COVID-19 in children and adolescents has increased during the delta and omicron waves, necessitating studies of long-term symptoms such as fatigue, dyspnoea and cognitive problems. Furthermore, ... -
Vacuolar ATPase Is a Possible Therapeutic Target in Acute Myeloid Leukemia: Focus on Patient Heterogeneity and Treatment Toxicity
(Journal article; Peer reviewed, 2023)Vacuolar ATPase (V-ATPase) is regarded as a possible target in cancer treatment. It is expressed in primary acute myeloid leukemia cells (AML), but the expression varies between patients and is highest for patients with a ... -
Disturbed lipid profile in common variable immunodeficiency – a pathogenic loop of inflammation and metabolic disturbances
(Journal article; Peer reviewed, 2023)The relationship between metabolic and inflammatory pathways play a pathogenic role in various cardiometabolic disorders and is potentially also involved in the pathogenesis of other disorders such as cancer, autoimmunity ... -
Myocardial Work in Middle-Aged Adults with Overweight and Obesity: Associations with Sex and Central Arterial Stiffness
(Journal article; Peer reviewed, 2023)We explored global myocardial work index (GWI), a novel measure of myocardial function that integrates left ventricular (LV) hemodynamic load, in relation to sex and increased body mass index (BMI). We used data from 467 ... -
Skin infiltrating NK cells in cutaneous T-cell lymphoma are increased in number and display phenotypic alterations partially driven by the tumor
(Journal article; Peer reviewed, 2023)Cutaneous T-cell lymphomas (CTCL) are characterized by focal infiltration of malignant T cell clones in solitary skin lesions. Many CTCL patients experience an indolent disease, but some progress to advanced disease with ... -
Antibody responses after influenza and SARS-CoV-2 vaccination and infection: Lessons across the ages
(Doctoral thesis, 2023-10-23)Influensa A og SARS-CoV-2 er RNA-baserte luftvegsvirus som forårsakar pandemiar og muterer raskt for å oppretthalde ein kontinuerleg sirkulasjon. Eit komplekst samspel mellom immunresponsar hjå verten og viruset er forma ... -
Clues to Diagnosis and Clinical Outcomes in Autoimmune Addison’s Disease
(Doctoral thesis, 2023-10-23)Forsinka diagnose av autoimmun Addisons sjukdom (AAS) aukar risikoen for ei potensielt dødeleg binyrekrise. Ved etablert sjukdom er det stor variasjon i kliniske utfall, med forskjellar i risiko for binyrekriser, kardiovaskulær ... -
Polygenic overlap with body-mass index improves prediction of treatment-resistant schizophrenia
(Journal article; Peer reviewed, 2023)Treatment resistant schizophrenia (TRS) is characterized by repeated treatment failure with antipsychotics. A recent genome-wide association study (GWAS) of TRS showed a polygenic architecture, but no significant loci were ... -
Association between lipid-A-producing oral bacteria of different potency and fractional exhaled nitric oxide in a Norwegian population-based adult cohort
(Journal article; Peer reviewed, 2023)Background Lipid A is the primary immunostimulatory part of the lipopolysaccharide (LPS) molecule. The inflammatory response of LPS varies and depends upon the number of acyl chains and phosphate groups in lipid A which ... -
Haemagglutination inhibition and virus microneutralisation serology assays: use of harmonised protocols and biological standards in seasonal influenza serology testing and their impact on inter-laboratory variation and assay correlation: A FLUCOP collaborative study
(Journal article; Peer reviewed, 2023)Introduction: The haemagglutination inhibition assay (HAI) and the virus microneutralisation assay (MN) are long-established methods for quantifying antibodies against influenza viruses. Despite their widespread use, both ...