Department of Clinical Science: Nye registreringer

Viser treff 461-480 av 2318

    • Genetic diversity of the flavohemoprotein gene of Giardia lamblia: Evidence for high allelic heterozygosity and copy number variation 

      Saghaug, Christina Skår; Klotz, Christian; Kallio, Juha Pekka; Aebischer, Toni; Langeland, Nina; Hanevik, Kurt (Journal article; Peer reviewed, 2020)
      Purpose: The flavohemoprotein (gFlHb) in Giardia plays an important role in managing nitrosative and oxidative stress, and potentially also in virulence and nitroimidazole drug tolerance. The aim of this study was to analyze ...

    • Genetic variability of proteins involved in metronidazole metabolism and detoxification in Giardia lamblia 

      Saghaug, Christina Skår (Doctoral thesis, 2021-12-09)
      Metronidazole (MTZ) treatment-refractory Giardia lamblia infections is an emerging global problem. Recent studies show that prevalence rates of refractory infections are 10-20 % and can be as high as 46 %. The recent global ...

    • Novel adipose genes in substrate- and depot-dependent lipid accumulation 

      Tallapragada, Divya Sri Priyanka (Doctoral thesis, 2021-06-24)
      Altered adipose tissue function in obesity is linked to increased risk of type 2 diabetes (T2D) and cardiometabolic diseases via insulin resistance, visceral adiposity, hypertension, and other traits. This thesis studied ...

    • A novel bicyclic lactone and other polyphenols from the commercially important vegetable Anthriscus cerefolium 

      Slimestad, Rune; Rathe, Bendik Auran; Aesoy, Reidun; Diaz, Andrea Estefania Carpinteyro; Herfindal, Lars; Fossen, Torgils (Journal article; Peer reviewed, 2022)
      Garden chervil, Anthriscus cerefolium (L.) Hoffm. is an important herb commonly applied in Norwegian large-scale commercial kitchens. This species is a highly enriched source of phenolics, containing 1260 mg gallic acid ...

    • Fluorochrome Selection for Imaging Intraoperative Ovarian Cancer Probes 

      Perrone, Maria Grazia; Vitale, Paola; Miciaccia, Morena; Ferorelli, Savina; Centonze, Antonella; Solidoro, Roberta; Munzone, Cristina; Bonaccorso, Carmela; Fortuna, Cosimo Gianluca; Kleinmanns, Katrin; Bjørge, Line; Scilimati, Antonio (Journal article; Peer reviewed, 2022)
      The identification and removal of all gross and microscopic tumor to render the patient disease free represents a huge challenge in ovarian cancer treatment. The presence of residual disease is an independent negative ...

    • DNA methylation changes in response to neoadjuvant chemotherapy are associated with breast cancer survival 

      Pedersen, Christine Aaserød; Cao, Maria Dung; Fleischer, Thomas; Rye, Morten Beck; Knappskog, Stian; Eikesdal, Hans Petter; Lønning, Per Eystein; Tost, Jörg; Kristensen, Vessela N.; Tessem, May-Britt; Giskeødegård, Guro F.; Bathen, Tone Frost (Journal article; Peer reviewed, 2022)
      Background: Locally advanced breast cancer is a heterogeneous disease with respect to response to neoadjuvant chemotherapy (NACT) and survival. It is currently not possible to accurately predict who will benefit from the ...

    • Impact on follow-up strategies in patients with primary sclerosing cholangitis 

      Bergquist, Annika; Weismüller, Tobias J.; Levy, Cynthia; Rupp, Christian; Joshi, Deepak; Nayagam, Jeremy Shanika; Montano-Loza, Aldo J.; Lytvyak, Ellina; Wunsch, Ewa; Milkiewicz, Piotr; Zenouzi, Roman; Schramm, Christoph; Cazzagon, Nora; Floreani, Annarosa; Liby, Ingalill Friis; Wiestler, Miriam; Wedemeyer, Heiner; Zhou, Taotao; Strassburg, Christian P.; Rigopoulou, Eirini; Dalekos, George; Narasimman, Manasa; Verhelst, Xavier; Degroote, Helena; Vesterhus, Mette Nåmdal; Kremer, Andreas E.; Bündgens, Bennet; Rorsman, Fredrik; Nilsson, Emma; Jørgensen, Kristin Kaasen; von Seth, Erik; Cornillet Jeannin, Martin; Nyhlin, Nils; Martin, Harry; Kechagias, Stergios; Wiencke, Kristine; Werner, Mårten; Beretta-Piccoli, Benedetta Terziroli; Marzioni, Marco; Isoniemi, Helena; Arola, Johanna; Wefer, Agnes; Söderling, Jonas; Färkkilä, Martti; Lenzen, Henrike (Journal article; Peer reviewed, 2022)
      Background & Aims: Evidence for the benefit of scheduled imaging for early detection of hepatobiliary malignancies in primary sclerosing cholangitis (PSC) is limited. We aimed to compare different follow-up strategies in ...

    • Alveolar function following extremely preterm birth 

      Satrell, Emma (Doctoral thesis, 2022-12-16)
      Bakgrunn: Ekstremt prematur (EP) fødsel skjer før normal lungeutvikling er fullført, og forstyrrer vekst og differensiering av alveolene. Mindre areal og tykkere membraner i alveolene gjør at lungenes evne til å drive ...

    • Development of lung diffusion to adulthood following extremely preterm birth 

      Satrell, Emma Elsa Carolina; Clemm, Hege Synnøve Havstad; Røksund, Ola Drange; Hufthammer, Karl Ove; Thorsen, Einar; Halvorsen, Thomas; Vollsæter, Maria (Journal article; Peer reviewed, 2022)
      Background: Gas exchange in extremely preterm (EP) infants must take place in fetal lungs. Childhood lung diffusing capacity of the lung for carbon monoxide (DLCO) is reduced; however, longitudinal development has not been ...

    • Brain plasticity after cognitive intervention in patients with mild cognitive impairment (MCI) evaluated by multimodal MR imaging in a randomized, controlled trial. 

      Hol, Haakon Ramsland (Doctoral thesis, 2022-12-16)
      Hjerneplasitisitet undersøkt hos individer med mild kognitiv svikt etter PC-administrert arbeidsminnetrening, evaluert med multimodal MRI teknikk, en randomisert kontroll studie. Formål: Hovedmålet med studien var å ...

    • Differences in lung function, bronchial hyperresponsiveness and respiratory health between elite athletes competing in different sports 

      Bernhardsen, Guro Pauck; Stang, Julie; Halvorsen, Thomas; Stensrud, Trine (Journal article; Peer reviewed, 2022)
      The aim of this study was to examine lung function, bronchial hyperresponsiveness (BHR) and exercise-induced respiratory symptoms in elite athletes performing different sports. Norwegian national-team athletes (30 swimmers, ...

    • Association of oral bacteria with oral hygiene habits and self-reported gingival bleeding 

      Bertelsen, Randi Jacobsen; Perez Barrionuevo, Antonio Manuel; Shigdel, Rajesh; Lie, Stein Atle; Lin, Huang; Real, Francisco Gomez; Ringel-Kulka, Tamar; Åstrøm, Anne-Kristine N; Svanes, Cecilie (Journal article; Peer reviewed, 2022)
      Aim To describe associations of gingival bacterial composition and diversity with self-reported gingival bleeding and oral hygiene habits in a Norwegian regional-based population. Materials and Methods We examined the ...

    • VACCELERATE Volunteer Registry: A European study participant database to facilitate clinical trial enrolment 

      Salmanton-García, Jon; Stewart, Fiona A.; Heringer, Sarah; Koniordou, Markela; Álvarez-Barco, Elena; Argyropoulos, Christos D.; Themistocleous, Sophia C.; Valle-Simón, Paula; Spivak, Orly; Součková, Lenka; Merakou, Christina; Amélia Mendonça, Maria; Joanna Davis, Ruth; Maria Azzini, Anna; Askling, Helena H.; Vene, Sirkka; Van Damme, Pierre; Steinbach, Angela; Shiamakkides, George; Seidel, Danila; Olesen, Ole F.; Noula, Evgenia; Macken, Alan; Luís, Catarina; Leckler, Janina; Launay, Odile; Isitt, Catherine; Hellemans, Margot; Frías-Iniesta, Jesús; Di Marzo, Romina; Carcas, Antonio J.; Boustras, George; Borobia, Alberto M.; Barta, Imre; Albus, Kerstin; Akova, Murat; Ochando, Jordi; Cohen-Kandli, Miriam; Cox, Rebecca Jane; Husa, Petr; Jancoriene, Ligita; Mallon, Patrick; Marques, Laura; Mellinghoff, Sibylle C.; Nauclér, Pontus; Tacconelli, Evelina; Tóth, Krisztina; Zaoutis, Theoklis E.; Zeitlinger, Markus; Cornely, Oliver A.; Pana, Zoi-Dorothea (Journal article; Peer reviewed, 2022)
      Introduction: The coronavirus disease 2019 (COVID-19) pandemic has evidenced the key role of vaccine design, obtention, production and administration to successfully fight against infectious diseases and to provide efficient ...

    • Host Transcriptional Signatures Predict Etiology in Community-Acquired Pneumonia: Potential Antibiotic Stewardship Tools 

      Siljan, William Ward; Sivakumaran, Dhanasekaran; Ritz, Christian; Jenum, Synne; Ottenhoff, Tom HM; Ulvestad, Elling; Holter, Jan Cato; Heggelund, Lars; Grewal, Harleen (Journal article; Peer reviewed, 2022)
      Background: Current approaches for pathogen identification in community-acquired pneumonia (CAP) remain suboptimal, leaving most patients without a microbiological diagnosis. If better diagnostic tools were available for ...

    • Shared genetic loci between depression and cardiometabolic traits 

      Torgersen, Kristin Stensland; Rahman, Zillur; Bahrami, Shahram; Hindley, Guy Frederick Lanyon; Parker, Nadine; Frei, Oleksandr; Shadrin, Alexey; O'Connell, Kevin Sean; Tesli, Martin Steen; Smeland, Olav Bjerkehagen; Munkhaugen, John; Djurovic, Srdjan; Dammen, Toril; Andreassen, Ole (Journal article; Peer reviewed, 2022-05-13)
      Epidemiological and clinical studies have found associations between depression and cardiovascular disease risk factors, and coronary artery disease patients with depression have worse prognosis. The genetic relationship ...

    • Transcriptomic Profiling Reveals That HMGB1 Induces Macrophage Polarization Different from Classical M1 

      Qu, Heshuang; Heinbäck, Rebecka; Salo, Henna; Ewing, Ewoud; Espinosa, Alexander; Aulin, Cecilia; Harris, Anna Helena Erlandsson (Journal article; Peer reviewed, 2022-06-02)
      Macrophages are key inflammatory immune cells that display dynamic phenotypes and functions in response to their local microenvironment. In different conditions, macrophage polarization can be induced by high-mobility group ...

    • Analysis of host-pathogen gene association networks reveals patient-specific response to streptococcal and polymicrobial necrotising soft tissue infections 

      Jahagirdar, Sanjeevan; Morris, Lorna; Benis, Nirupama; Oppegaard, Oddvar; Svenson, Mattias; Hyldegaard, Ole; Skrede, Steinar; Norrby-Teglund, Anna; Bruun, Trond; Rath, Eivind; Nedrebø, Torbjørn; Arnell, Per; Rosen, Anders; Hedetoft, Morten; Madsen, Martin B.; Svensson, Mattias; Snäll, Johanna; Karlsson, Ylva; Nekludov, Michael; Martins dos Santos, Vitor A. P.; Saccenti, Edoardo (Journal article; Peer reviewed, 2022)
      Background: Necrotising soft tissue infections (NSTIs) are rapidly progressing bacterial infections usually caused by either several pathogens in unison (polymicrobial infections) or Streptococcus pyogenes (mono-microbial ...

    • Radiation induced brain necrosis after proton therapy for head and neck cancer 

      Engeseth, Grete May (Doctoral thesis, 2022-12-09)
      Protonterapi gir reduksjon i normalvevsdoser sammenlignet med strålebehandling med fotoner, og det er antatt at dette vil resultere i en lavere forekomst av stråleinduserte seinskader. For å kompensere for en økt biologisk ...

    • Neuronal Dysfunction Is Linked to the Famine-Associated Risk of Proliferative Retinopathy in Patients With Type 2 Diabetes 

      Fedotkina, Olena; Jain, Ruchi; Prasad, Rashmi B.; Luk, Andrea; García-Ramírez, Marta; Özgümüs, Türküler; Cherviakova, Liubov; Khalimon, Nadiya; Svietleisha, Tetiana; Buldenko, Tetiana; Kravchenko, Victor; Jain, Deepak; Vaag, Allan; Chan, Juliana; Khalangot, Mykola D.; Hernández, Cristina; Nilsson, Peter M.; Simo, Rafael; Artner, Isabella; Lyssenko, Valeriya (Journal article; Peer reviewed, 2022-05-05)
      Persons with type 2 diabetes born in the regions of famine exposures have disproportionally elevated risk of vision-threatening proliferative diabetic retinopathy (PDR) in adulthood. However, the underlying mechanisms are ...

    • Clonal evolution after treatment pressure in multiple myeloma: heterogenous genomic aberrations and transcriptomic convergence 

      Misund, Kristine; Hofste op Bruinink, Davine; Coward, Eivind; Hoogenboezem, Remco M.; Rustad, Even Holth; Sanders, Mathijs A.; Rye, Morten Beck; Sponaas, Anne-Marit; van der Holt, Bronno; Zweegman, Sonja; Hovig, Eivind; Meza, Leonardo Zepeda; Sundan, Anders; Myklebost, Ola; Sonneveld, Pieter; Waage, Anders (Journal article; Peer reviewed, 2022)
      We investigated genomic and transcriptomic changes in paired tumor samples of 29 in-house multiple myeloma (MM) patients and 28 patients from the MMRF CoMMpass study before and after treatment. A change in clonal composition ...