Department of Clinical Science: Nye registreringer
Viser treff 541-560 av 2318
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Symptoms and antecedents of autism in children born extremely premature: a national population-based study
(Journal article; Peer reviewed, 2022)The objective of this study is to investigate the prevalence of autism (ASD) symptoms, i.e. , social difficulties, repetitive behaviors, and communicational problems, among children born extremely preterm (EP) compared to ... -
KRAS-G12C mutation in one real-life and three population-based Nordic cohorts of metastatic colorectal cancer
(Journal article; Peer reviewed, 2022-02-16)Background: KRAS mutations, present in over 40% of metastatic colorectal cancer (mCRC), are negative predictive factors for anti-EGFR therapy. Mutations in KRAS-G12C have a cysteine residue for which drugs have been ... -
Metabolic and Epigenetic Regulation by Estrogen in Adipocytes
(Journal article; Peer reviewed, 2022-02-22)Sex hormones contribute to differences between males and females in body fat distribution and associated disease risk. Higher concentrations of estrogens are associated with a more gynoid body shape and with more fat storage ... -
Species Level Description of the Human Ileal Bacterial Microbiota
(Journal article; Peer reviewed, 2018)The small bowel is responsible for most of the body’s nutritional uptake and for the development of intestinal and systemic tolerance towards microbes. Nevertheless, the human small bowel microbiota has remained poorly ... -
Consistent biofilm formation by Streptococcus pyogenes emm 1 isolated from patients with necrotizing soft tissue infections
(Journal article; Peer reviewed, 2022-02-18)Objectives: Biofilm formation has been demonstrated in muscle and soft tissue samples from patients with necrotizing soft tissue infection (NSTI) caused by Streptococcus pyogenes, but the clinical importance of this ... -
Postpartum hemorrhage in families : A Norwegian population-based study
(Doctoral thesis, 2022-10-27)Bakgrunn: Postpartum blødning (PPB) er den ledende direkte årsaken til verdens mødredødelighet og forekomsten har en økende trend i utviklende land. Mål: Å studere gjentagelsesrisiko for PPB hos en kvinne, over generasjoner ... -
Investigating the human small intestinal microbiota : Microbiological characterization of jejunal and ileal samples collected during surgery
(Doctoral thesis, 2022-10-25)Kartlegging av tynntarmsmikrobiota hos mennesker : Mikrobiologisk beskrivelse av kirurgiske prøver fra jejunum og ileum Beskrivelser av tynntarmsmikrobiota (tarmflora) i lærebøker og vitenskapelige artikler er lite ... -
Deciphering rare imprinting disorders within the Beckwith-Wiedemann spectrum
(Doctoral thesis, 2022-10-28)Beckwith-Wiedemann syndrom (BWS) er den hyppigste og mest komplekse tilstanden blant imprintingssykdommene. Avhandlingen presenterer tre ulike BWS spektrum familier, hvor vi utvider forståelsen av arvemønsteret ved BWS, ... -
Genome-wide meta-analysis for Alzheimer’s disease cerebrospinal fluid biomarkers
(Journal article; Peer reviewed, 2022)Amyloid-beta 42 (Aβ42) and phosphorylated tau (pTau) levels in cerebrospinal fluid (CSF) reflect core features of the pathogenesis of Alzheimer’s disease (AD) more directly than clinical diagnosis. Initiated by the European ... -
Evaluating Translational Methods for Personalized Medicine—A Scoping Review
(Journal article; Peer reviewed, 2022)The introduction of personalized medicine, through the increasing multi-omics characterization of disease, brings new challenges to disease modeling. The scope of this review was a broad evaluation of the relevance, validity, ... -
Deep exploration of a CDKN1C mutation causing a mixture of Beckwith-Wiedemann and IMAGe syndromes revealed a novel transcript associated with developmental delay
(Journal article; Peer reviewed, 2022)Background: Loss-of-function mutations in CDKN1C cause overgrowth, that is, Beckwith-Wiedemann syndrome (BWS), while gain-of-function variants in the gene’s PCNA binding motif cause a growth-restricted condition called ... -
A national intercalated medical student research program–student perceptions, satisfaction, and factors associated with pursuing a PhD
(Journal article; Peer reviewed, 2022)Background: To counteract a decreasing number of physician-scientists, a national intercalated Medical Student Research Programme (MSRP) was launched in Norway in 2002. We aimed to assess whether the students’ favourable ... -
Compliance with Guidelines and Efficacy of Heart Rate Monitoring during Newborn Resuscitation: A Prospective Video Study
(Journal article; Peer reviewed, 2020)Objective: Newborn resuscitation guidelines recommend initial assessment of heart rate (HR) and initiation of positive pressure ventilation (PPV) within 60 s after birth in non-breathing newborns. Pulse oximeter (PO) and ... -
Changes in heart rate from 5 s to 5 min after birth in vaginally delivered term newborns with delayed cord clamping
(Journal article; Peer reviewed, 2021)Objective: To determine heart rate centiles during the first 5 min after birth in healthy term newborns delivered vaginally with delayed cord clamping. Design: Single-centre prospective observational study. Setting: ... -
A prospective observational study on newborn resuscitation in a high-resource setting
(Doctoral thesis, 2022-10-28)Bakgrunn: Omkring åtte prosent av verdens nyfødte har behov for pustehjelp for å klare overgangen fra intra- til ekstrauterint liv. Nøyaktig forekomst er usikker og varierer antagelig mellom ulike settinger, men resuscitering ... -
A genome-wide association study of bronchodilator response in participants of European and African ancestry from six independent cohorts
(Journal article; Peer reviewed, 2022)Introduction Bronchodilator response (BDR) is a measurement of acute bronchodilation in response to short-acting β2-agonists, with a heritability between 10 and 40%. Identifying genetic variants associated with BDR may ... -
Fucosylated AGP glycopeptides as biomarkers of HNF1A-Maturity onset diabetes of the young
(Journal article; Peer reviewed, 2022)Aims: We previously demonstrated that antennary fucosylated N-glycans on plasma proteins are regulated by HNF1A and can identify cases of Maturity-Onset Diabetes of the Young caused by HNF1A variants (HNF1A-MODY). Based ... -
Cryoballoon vs. radiofrequency catheter ablation: insights from NOrwegian randomized study of PERSistent Atrial Fibrillation (NO-PERSAF study)
(Journal article; Peer reviewed, 2022)Aims Pulmonary vein isolation (PVI) is still regarded as a cornerstone for treatment of persistent atrial fibrillation (AF). This study evaluated the effectiveness of PVI performed with cryoballoon ablation (CBA) in ... -
The relationship between lipoprotein A and other lipids with prostate cancer risk: A multivariable Mendelian randomisation study
(Journal article; Peer reviewed, 2022)Background Numerous epidemiological studies have investigated the role of blood lipids in prostate cancer (PCa) risk, though findings remain inconclusive to date. The ongoing research has mainly involved observational ... -
The DNA methylome of cervical cells can predict the presence of ovarian cancer
(Journal article; Peer reviewed, 2022)The vast majority of epithelial ovarian cancer arises from tissues that are embryologically derived from the Müllerian Duct. Here, we demonstrate that a DNA methylation signature in easy-to-access Müllerian Duct-derived ...