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dc.contributor.authorFromm, Annetteen_US
dc.contributor.authorThomassen, Larsen_US
dc.contributor.authorNæss, Halvoren_US
dc.contributor.authorMeijer, Rudyen_US
dc.contributor.authorEide, Geir Egilen_US
dc.contributor.authorKråkenes, Josteinen_US
dc.contributor.authorVedeler, Christian A.en_US
dc.contributor.authorGerdts, Evaen_US
dc.contributor.authorLarsen, Terje H.en_US
dc.contributor.authorKuiper, Karel Kier-Janen_US
dc.contributor.authorLaxdal, Elin Hannaen_US
dc.contributor.authorRussell, Daviden_US
dc.contributor.authorTatlisumak, Turguten_US
dc.contributor.authorWaje-Andreassen, Ulrikeen_US
dc.description.abstractBackground: Ischemic stroke in young adults is a major health problem being associated with a higher vascular morbidity and mortality compared to controls, and a stroke recurrence rate of 25% during the first decade. The assumed cause of infarction and the detected risk factors determine the early- and long-term treatment. However, for many patients the cause of stroke remains unknown. Risk factor profile and etiology differ in young and elderly ischemic stroke patients, and atherosclerosis is the determined underlying condition in 10 to 15%. However, subclinical atherosclerosis is probably more prevalent and may go unrecognized. Ultrasound imaging is a sensitive method for the detection of arterial disease and for measurement of adipose tissue. The relationship between intima-media thickness (IMT), plaques, cardiovascular risk factors including visceral adipose tissue (VAT) and ischemic events has repeatedly been shown. We have established The Norwegian Stroke in the Young Study (NOR-SYS) as a three-generation research program with the goal to increase our knowledge on heredity and the development of arterial disease and ischemic stroke. Extended standardized ultrasound examinations are done in order to find subclinical vessel disease for early and better prophylaxis. Methods/Design: NOR-SYS is a prospective long-term research program. Standardized methods are used for anamnestic, clinical, laboratory, imaging, and ultrasound data collection in ischemic stroke patients aged ≤60 years, their partners and joint adult offspring. The ultrasound protocol includes the assessment of intracranial, carotid and femoral arteries, abdominal aorta, and the estimation of VAT. To date, the study is a single centre study with approximately 400 patients, 250 partners and 350 adult offspring expected to be recruited at our site. Discussion: NOR-SYS aims to increase our knowledge about heredity and the development of arterial vascular disease in young patients with ischemic stroke and their families. Moreover, optimization of diagnostics, prophylaxis and early intervention are major targets with the intention to reduce stroke recurrence and other clinical arterial events, physical disability, cognitive impairment and death.en_US
dc.publisherBioMed Centraleng
dc.relation.ispartof<a href="" target="blank">Ischemic stroke and atherosclerosis at a young age. The Norwegian Stroke in the Young Study</a>
dc.rightsAttribution CC BYeng
dc.subjectIschemic strokeeng
dc.subjectStroke in the youngeng
dc.subjectArterial diseaseeng
dc.subjectVascular riskeng
dc.subjectLong-term outcomeeng
dc.titleThe Norwegian Stroke in the Young Study (NOR-SYS): rationale and designen_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright 2013 Fromm et al.; licensee BioMed Central Ltd.
dc.rights.holderAnnette Fromm et al.; licensee BioMed Central Ltd.
dc.source.journalBMC Neurology

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