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dc.contributor.authorØksnes, Marianneen_US
dc.contributor.authorBensing, Sophieen_US
dc.contributor.authorHulting, Anna-Lenaen_US
dc.contributor.authorKämpe, Olleen_US
dc.contributor.authorHackemann, Annikaen_US
dc.contributor.authorMeyer, Gesineen_US
dc.contributor.authorBadenhoop, Klausen_US
dc.contributor.authorBetterle, Corradoen_US
dc.contributor.authorParolo, Annaen_US
dc.contributor.authorGiordano, Robertaen_US
dc.contributor.authorFalorni, Albertoen_US
dc.contributor.authorPapierska, Lucynaen_US
dc.contributor.authorJeske, Wojciechen_US
dc.contributor.authorKasperlik-Zaluska, Anna A.en_US
dc.contributor.authorChatterjee, V. Krishna K.en_US
dc.contributor.authorHusebye, Eystein Sverreen_US
dc.contributor.authorLøvås, Kristianen_US
dc.date.accessioned2014-08-22T07:28:17Z
dc.date.available2014-08-22T07:28:17Z
dc.date.issued2012-02eng
dc.identifier.issn1945-7197
dc.identifier.issn0021-972X
dc.identifier.urihttps://hdl.handle.net/1956/8317
dc.description.abstractContext: Patients with Addison’s disease (AD) self-report impairment in specific dimensions on well-being questionnaires. An AD-specific quality-of-life questionnaire (AddiQoL) was developed to aid evaluation of patients. Objective: We aimed to translate and determine construct validity, reliability, and concurrent validity of the AddiQoL questionnaire. Methods: After translation, the final versions were tested in AD patients from Norway (n = 107), Sweden (n = 101), Italy (n = 165), Germany (n = 200), and Poland (n = 50). Construct validity was examined by exploratory factor analysis and Rasch analysis, aiming at unidimensionality and fit to the Rasch model. Reliability was determined by Cronbach’s coefficient- and Person separation index. Longitudinal reliability was tested by differential item functioning in stable patient subgroups. Concurrent validity was examined in Norwegian (n = 101) and Swedish (n = 107) patients. Results: Exploratory factor analysis and Rasch analysis identified six items with poor psychometric properties. The 30 remaining items fitted the Rasch model and proved unidimensional, supported by appropriate item and person fit residuals and a nonsignificant X² probability. Crohnbach’s α-coefficient 0.93 and Person separation index 0.86 indicate high reliability. Longitudinal reliability was excellent. Correlation with Short Form-36 and Psychological General Well-Being Index scores was high. A shorter subscale comprising eight items also proved valid and reliable. Testing of AddiQoL-30 in this large patient cohort showed significantly worse scores with increasing age and inwomencompared withmenbutnodifference between patients with isolatedADand those with concomitant diseases. Conclusion: The validation process resulted in a revised 30-item AddiQoL questionnaire and an eight-item AddiQoL short version with good psychometric properties and high reliability.en_US
dc.language.isoengeng
dc.publisherEndocrine Societyeng
dc.relation.ispartof<a href="http://hdl.handle.net/1956/8326" target="blank">Glucocorticoid Treatment and Quality of Life in Addison’s disease</a>eng
dc.titleQuality of Life in European Patients with Addison’s Disease: Validity of the Disease-Specific Questionnaire AddiQoLen_US
dc.typePeer reviewed
dc.typeJournal article
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright 2012 by The Endocrine Society
dc.identifier.doihttps://doi.org/10.1210/jc.2011-1901
dc.identifier.cristin928478
dc.source.journalJournal of Clinical Endocrinology and Metabolism
dc.source.4097
dc.source.142
dc.source.pagenumber568-576


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