dc.contributor.author | Abecasis, Ana B. | en_US |
dc.contributor.author | Wensing, Annemarie M. J. | en_US |
dc.contributor.author | Paraskevis, Dimitris | en_US |
dc.contributor.author | Vercauteren, Jurgen | en_US |
dc.contributor.author | Theys, Kristof | en_US |
dc.contributor.author | Van de Vijver, David A. M. C. | en_US |
dc.contributor.author | Albert, Jan | en_US |
dc.contributor.author | Åsjø, Birgitta | en_US |
dc.contributor.author | Balotta, Claudia | en_US |
dc.contributor.author | Beshkov, Danail | en_US |
dc.contributor.author | Camacho, Ricardo J. | en_US |
dc.contributor.author | Clotet, Bonaventura | en_US |
dc.contributor.author | De Gascun, Cillian | en_US |
dc.contributor.author | Griskevicius, Algis | en_US |
dc.contributor.author | Grossman, Zehava | en_US |
dc.contributor.author | Hamouda, Osamah | en_US |
dc.contributor.author | Horban, Andrzej | en_US |
dc.contributor.author | Kolupajeva, Tatjana | en_US |
dc.contributor.author | Korn, Klaus | en_US |
dc.contributor.author | Kostrikis, Leon G. | en_US |
dc.contributor.author | Kücherer, Claudia | en_US |
dc.contributor.author | Liitsola, Kirsi | en_US |
dc.contributor.author | Linka, Marek | en_US |
dc.contributor.author | Nielsen, Claus | en_US |
dc.contributor.author | Otelea, Dan | en_US |
dc.contributor.author | Paredes, Roger | en_US |
dc.contributor.author | Poljak, Mario | en_US |
dc.contributor.author | Puchhammer-Stöckl, Elisabeth | en_US |
dc.contributor.author | Schmit, Jean-Claude | en_US |
dc.contributor.author | Sönnerborg, Anders | en_US |
dc.contributor.author | Stanekova, Danika | en_US |
dc.contributor.author | Stanojevic, Maja | en_US |
dc.contributor.author | Struck, Daniel | en_US |
dc.contributor.author | Boucher, Charles A. B. | en_US |
dc.contributor.author | Vandamme, Anne-Mieke | en_US |
dc.date.accessioned | 2014-09-23T13:17:53Z | |
dc.date.available | 2014-09-23T13:17:53Z | |
dc.date.issued | 2013-01-14 | eng |
dc.identifier.issn | 1742-4690 | |
dc.identifier.uri | https://hdl.handle.net/1956/8530 | |
dc.description.abstract | Background: Understanding HIV-1 subtype distribution and epidemiology can assist preventive measures and clinical decisions. Sequence variation may affect antiviral drug resistance development, disease progression, evolutionary rates and transmission routes. Results: We investigated the subtype distribution of HIV-1 in Europe and Israel in a representative sample of patients diagnosed between 2002 and 2005 and related it to the demographic data available. 2793 PRO-RT sequences were subtyped either with the REGA Subtyping tool or by a manual procedure that included phylogenetic tree and recombination analysis. The most prevalent subtypes/CRFs in our dataset were subtype B (66.1%), followed by sub-subtype A1 (6.9%), subtype C (6.8%) and CRF02_AG (4.7%). Substantial differences in the proportion of new diagnoses with distinct subtypes were found between European countries: the lowest proportion of subtype B was found in Israel (27.9%) and Portugal (39.2%), while the highest was observed in Poland (96.2%) and Slovenia (93.6%). Other subtypes were significantly more diagnosed in immigrant populations. Subtype B was significantly more diagnosed in men than in women and in MSM > IDUs > heterosexuals. Furthermore, the subtype distribution according to continent of origin of the patients suggests they acquired their infection there or in Europe from compatriots. Conclusions: The association of subtype with demographic parameters suggests highly compartmentalized epidemics, determined by social and behavioural characteristics of the patients. | en_US |
dc.language.iso | eng | eng |
dc.publisher | BioMed Central | eng |
dc.rights | Attribution CC BY | eng |
dc.rights.uri | http://creativecommons.org/licenses/by/2.0 | eng |
dc.title | HIV-1 subtype distribution and its demographic determinants in newly diagnosed patients in Europe suggest highly compartmentalized epidemics | en_US |
dc.type | Peer reviewed | |
dc.type | Journal article | |
dc.date.updated | 2013-08-23T08:56:43Z | |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | Copyright 2013 Abecasis et al.; licensee BioMed Central Ltd. | |
dc.rights.holder | Ana B Abecasis et al.; licensee BioMed Central Ltd. | |
dc.source.articlenumber | 7 | |
dc.identifier.doi | https://doi.org/10.1186/1742-4690-10-7 | |
dc.identifier.cristin | 1028229 | |
dc.source.journal | Retrovirology | |
dc.source.40 | 10 | |