dc.contributor.author | Sønnesyn, Hogne | en_US |
dc.contributor.author | Dalen, Ingvild | en_US |
dc.contributor.author | Aarsland, Dag | en_US |
dc.date.accessioned | 2014-10-02T07:48:49Z | |
dc.date.available | 2014-10-02T07:48:49Z | |
dc.date.issued | 2014 | eng |
dc.identifier.issn | 1664-5464 | |
dc.identifier.uri | https://hdl.handle.net/1956/8581 | |
dc.description.abstract | Aim: To study the course and prognostic implications of orthostatic hypotension (OH) in older individuals with mild-to-moderate dementia. Methods: Referrals to outpatient clinics specialising in old age psychiatry and geriatric medicine in the counties of Rogaland and Hordaland in western Norway with a first-time diagnosis of mild dementia were consecutively asked for inclusion. A total of 211 participants underwent a comprehensive baseline assessment with annual follow-ups. Patients with OH at both baseline and the 1-year follow-up were classified as having persistent OH. Outcome measures were the Mini-Mental State Examination (MMSE), the Clinical Dementia Rating sum of boxes (CDR-SB), and time to death. Results: From baseline to the 4-year follow-up, 30–45% of the participants had OH at each follow-up. In multivariable analysis, persistent OH was not significantly associated with either the longitudinal course of MMSE or CDR-SB scores or survival. Conclusions: OH was moderately prevalent over 4 years in older individuals with mild dementia, and persistent OH did not predict either cognitive or functional decline or survival. | en_US |
dc.language.iso | eng | eng |
dc.publisher | Karger | eng |
dc.relation.ispartof | <a href="http://hdl.handle.net/1956/8578" target="blank">Frequency and prognostic implications of orthostatic hypotension and white matter hyperintensities in older people with mild dementia</a> | eng |
dc.rights | Attribution-NonCommercial CC BY-NC | eng |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/3.0/ | eng |
dc.subject | Dementia | eng |
dc.subject | Orthostatic hypotension | eng |
dc.subject | Survival analysis | eng |
dc.title | Persistence and Prognostic Implications of Orthostatic Hypotension in Older Individuals with Mild-to-Moderate Dementia | en_US |
dc.type | Peer reviewed | |
dc.type | Journal article | |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | Copyright 2014 S. Karger AG. This is an Open Access article licensed under the terms of the Creative Commons Attribution- NonCommercial 3.0 Unported license (CC BY-NC). | |
dc.identifier.doi | https://doi.org/10.1159/000363514 | |
dc.source.journal | Dementia and geriatric cognitive disorders extra | |
dc.source.40 | 4 | |
dc.source.14 | 2 | |
dc.source.pagenumber | 283-296 | |