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dc.contributor.authorSchwarzlmüller, Thomasen_US
dc.contributor.authorBrauckhoff, Katrinen_US
dc.contributor.authorLøvås, Kristianen_US
dc.contributor.authorBiermann, Martinen_US
dc.contributor.authorBrauckhoff, Michaelen_US
dc.date.accessioned2014-10-08T13:26:37Z
dc.date.available2014-10-08T13:26:37Z
dc.date.issued2014-04-23eng
dc.identifier.issn1471-2482
dc.identifier.urihttps://hdl.handle.net/1956/8613
dc.description.abstractBackground: Radioguided surgery using 99m-Technetium-methoxyisobutylisonitrile (99mTc-MIBI) has been recommended for the surgical treatment of mediastinal parathyroid adenomas. However, high myocardial 99mTc-MIBI uptake may limit the feasibility of radioguided surgery in aortopulmonary window parathyroid adenoma. Case presentation: Two female patients aged 72 (#1) and 79 years (#2) with primary hyperparathyroidism caused by parathyroid adenomas in the aortopulmonary window were operated by transsternal radioguided surgery. After intravenous injection of 370 MBq 99mTc-MIBI at start of surgery, the maximum radioactive intensity (as counts per second) was measured over several body regions using a gamma probe before and after removal of the parathyroid adenoma. Relative radioactivity was calculated in relation to the measured ex vivo radioactivity of the adenoma, which was set to 1.0. Both patients were cured by uneventful removal of aortopulmonary window parathyroid adenomas of 4400 (#1) and 985 mg (#2). Biochemical cure was documented by intraoperative measurement of parathyroid hormone as well as follow-up examination. Ex vivo radioactivity over the parathyroid adenomas was 196 (#1) and 855 counts per second (#2). Before parathyroidectomy, relative radioactivity over the aortopulmonary window versus the heart was found at 1.3 versus 2.6 (#1) and 1.8 versus 4.8 (#2). After removal of the adenomas, radioactivity within the aortopulmonary window was only slightly reduced. Conclusion: High myocardial uptake of 99mTc-MIBI limits the feasibility of radioguided surgery in aortopulmonary parathyroid adenoma.en_US
dc.language.isoengeng
dc.publisherBioMed Centraleng
dc.rightsAttribution CC BYeng
dc.rights.urihttp://creativecommons.org/licenses/by/2.0eng
dc.subject99mTc-MIBI scintigraphyeng
dc.subjectAortopulmonary window parathyroid adenomaeng
dc.subjectRadioguided surgeryeng
dc.subjectPrimary hyperparathyroidismeng
dc.titleHigh cardiac background activity limits 99mTc-MIBI radioguided surgery in aortopulmonary window parathyroid adenomasen_US
dc.typePeer reviewed
dc.typeJournal article
dc.date.updated2014-04-29T11:40:34Z
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright 2014 Schwarzlmüller et al.; licensee BioMed Central Ltd.
dc.rights.holderThomas Schwarzlmüller et al.; licensee BioMed Central Ltd.
dc.source.articlenumber22
dc.identifier.doihttps://doi.org/10.1186/1471-2482-14-22
dc.identifier.cristin1160602
dc.source.journalBMC Surgery
dc.source.4014


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