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dc.contributor.authorNordal, Hilde Haugedalen_US
dc.contributor.authorBrun, Johan Gorgasen_US
dc.contributor.authorHalse, Anne-Kristineen_US
dc.contributor.authorJonsson, Rolanden_US
dc.contributor.authorFagerhol, Magne Kristofferen_US
dc.contributor.authorHammer, Hilde Berneren_US
dc.date.accessioned2014-10-13T13:39:25Z
dc.date.available2014-10-13T13:39:25Z
dc.date.issued2014-10-04eng
dc.identifier.issn1471-2474
dc.identifier.urihttps://hdl.handle.net/1956/8632
dc.description.abstractBackground: The calcium-binding protein S100A12 correlates with measures of disease activity in patients with rheumatoid arthritis (RA). The protein reflects neutrophil activation and the present objective was to explore in a pilot study the associations between S100A12 and other inflammatory markers, clinical assessments as well as degree of synovitis detected by a comprehensive ultrasonography (US) examination in RA patients during biologic treatment. Methods: Twenty patients with RA were examined clinically and by use of US as well as laboratory markers S100A12, calprotectin, C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) before starting adalimumab, with follow-up after 1, 3, 6 and 12 months. Ultrasonographic B-mode (BM) and power Doppler (PD) assessments of 78 joints, 36 tendons/tendon groups and 2 bursas were performed, and sum US scores calculated. Wilcoxon signed rank test assessed treatment response and Spearman rank correlation test was used to calculate correlations. Results: The concentrations of S100A12 decreased after 3 months (p < 0.01) and significant correlations were found between S100A12 and the other laboratory markers during follow-up (0.50-0.62, p < 0.05). Of the clinical assessments, S100A12 had highest correlations with the assessor’s global VAS (0.46-0.85, p < 0.05). Compared with CRP and ESR, S100A12 showed higher correlations with the sum US scores (both BM and PD), with median (range) correlation coefficients of 0.55 (0.35-0.78 (NS-p < 0.001)) for sum BM scores and 0.45 (0.27-0.75 (NS-p < 0.001)) for sum PD scores. Conclusions: The S100A12 protein was significantly associated with other inflammatory markers, clinical assessments as well as sum US scores, indicating that S100A12 is a potential marker of inflammation in RA patients.en_US
dc.language.isoengeng
dc.publisherBioMed Centraleng
dc.rightsAttribution CC BYeng
dc.rights.urihttp://creativecommons.org/licenses/by/4.0eng
dc.subjectS100 proteinseng
dc.subjectS100A12eng
dc.subjectUltrasonographyeng
dc.subjectRheumatoid arthritiseng
dc.subjectInflammationeng
dc.subjectBiologic therapyeng
dc.titleThe neutrophil protein S100A12 is associated with a comprehensive ultrasonographic synovitis score in a longitudinal study of patients with rheumatoid arthritis treated with adalimumaben_US
dc.typePeer reviewed
dc.typeJournal article
dc.date.updated2014-10-11T03:02:55Z
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright 2014 Nordal et al.; licensee BioMed Central Ltd.
dc.rights.holderHilde Haugedal Nordal et al.; licensee BioMed Central Ltd.
dc.source.articlenumber335
dc.identifier.doihttps://doi.org/10.1186/1471-2474-15-335
dc.identifier.cristin1162606
dc.source.journalBMC Musculoskeletal Disorders
dc.source.4015


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