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dc.contributor.authorElvevoll, Bjørgen_US
dc.contributor.authorHusby, Paulen_US
dc.contributor.authorØvrebø, Kjellen_US
dc.contributor.authorHaugen, Oddbjørnen_US
dc.description.abstractBackground: Intra-abdominal hypertension and abdominal compartment syndrome contribute significantly to increased morbidity and mortality in critically ill patients. This study describes pathophysiologic effects of the acutely elevated intra-abdominal pressure on microvascular fluid exchange and microcirculation. The resulting changes could contribute to development of organ dysfunction or failure. Methods: 16 pigs were randomly allocated to a control-group (C-group) or an interventional group (P-group). After 60 min of stabilization, intra-abdominal pressure of the P-group animals was elevated to 15 mmHg by Helium insufflation and after 120 min to a level of 30 mmHg for two more hours. The C-group animals were observed without insufflation of gas. Laboratory and hemodynamic parameters, plasma volume, plasma colloid osmotic pressure, total tissue water content, tissue perfusion, markers of inflammation and cerebral energy metabolism were measured and net fluid balance and fluid extravasation rates calculated. Analysis of variance for repeated measurements with post-tests were used to evaluate the results with respect to differences within or between the groups. Results: In the C-group hematocrit, net fluid balance, plasma volume and the fluid extravasation rate remained essentially unchanged throughout the study as opposed to the increase in hematocrit (P < 0.001), fluid extravasation rate (P < 0.05) and decrease in plasma volume (P < 0.001) of the P-group. Hemodynamic parameters remained stable or were slightly elevated in the C-group while the P-group demonstrated an increase in femoral venous pressure (P < 0.001), right atrial pressure (P < 0.001), pulmonary capillary wedge pressure (P < 0.01) and mean pulmonary arterial pressure (P < 0.001). The protein mass decreased in both study groups but was significantly lower in the P-group as compared with the C-group, after 240 min of intervention. The increased intra-abdominal pressure was associated with elevated intracranial pressure and reduced tissue perfusion of the pancreas and the gastric- and intestinal mucosa. Conclusion: Elevation of intra-abdominal pressure has an immediate impact on microvascular fluid extravasation leading to plasma volume contraction, reduced cardiac output and deranged perfusion of abdominal organs.en_US
dc.publisherBioMed Centraleng
dc.rightsAttribution CC BYeng
dc.subjectIntra-abdominal hypertensioneng
dc.subjectFluid extravasationeng
dc.subjectProtein extravasationeng
dc.titleAcute elevation of intra-abdominal pressure contributes to extravascular shift of fluid and proteins in an experimental porcine modelen_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright 2014 Elvevoll et al.; licensee BioMed Central Ltd
dc.rights.holderBjørg Elvevoll et al.; licensee BioMed Central Ltd.
dc.source.journalBMC Research Notes

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