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Browsing Faculty of Medicine by Journals "FEBS Open Bio"

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    • PKU mutation p.G46S prevents the stereospecific binding of l-phenylalanine to the dimer of human phenylalanine hydroxylase regulatory domain 

      Leandro, João; Saraste, Jaakko; Leandro, Paula; Flatmark, Torgeir (Peer reviewed; Journal article, 2017-02)
      Mammalian phenylalanine hydroxylase (PAH) has a potential allosteric regulatory binding site for l‐phenylalanine (l‐Phe), in addition to its catalytic site. This arrangement is supported by a crystal structure of a homodimeric ...
    • Post-translational modifications of Annexin A2 are linked to its association with perinuclear nonpolysomal mRNP complexes 

      Aukrust, Ingvild; Rosenberg, Linn Andersen; Ankerud, Mia Madeleine; Bertelsen, Vibeke; Hollås, Hanne; Saraste, Jaakko; Grindheim, Ann Kari; Vedeler, Anni (Peer reviewed; Journal article, 2017-02)
      Various post-translational modifications (PTMs) regulate the localisation and function of the multifunctional protein Annexin A2 (AnxA2). In addition to its various tasks as a cytoskeletal- and membrane-associated protein, ...
    • Structural and thermodynamic insight into phenylalanine hydroxylase from the human pathogen Legionella pneumophila 

      Leiros, Hanna-Kirsti S.; Flydal, Marte Innselset; Martinez, Aurora (Peer reviewed; Journal article, 2013-08-19)
      Phenylalanine hydroxylase from Legionella pneumophila (lpPAH) has a major functional role in the synthesis of the pigment pyomelanin, which is a potential virulence factor. We present here the crystal structure of lpPAH, ...

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