Blar i Faculty of Medicine på tidsskrift "Frontiers in Cell and Developmental Biology"
Viser treff 1-12 av 12
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Bortezomib abrogates temozolomide-induced autophagic flux through an ATG5 dependent pathway
(Journal article; Peer reviewed, 2022)Introduction: Glioblastoma (GBM) is invariably resistant to temozolomide (TMZ) chemotherapy. Inhibiting the proteasomal pathway is an emerging strategy to accumulate damaged proteins and inhibit their lysosomal degradation. ... -
Distinct Mitochondrial Remodeling During Mesoderm Differentiation in a Human-Based Stem Cell Model
(Journal article; Peer reviewed, 2021-10-14)Given the considerable interest in using stem cells for modeling and treating disease, it is essential to understand what regulates self-renewal and differentiation. Remodeling of mitochondria and metabolism, with the shift ... -
Editorial: Golgi Dynamics in Physiological and Pathological Conditions
(Journal article; Peer reviewed, 2020-01-29) -
Ferroptosis Holds Novel Promise in Treatment of Cancer Mediated by Non-coding RNAs
(Journal article; Peer reviewed, 2021)Ferroptosis is a newly identified form of regulated cell death that is associated with iron metabolism and oxidative stress. As a physiological mechanism, ferroptosis selectively removes cancer cells by regulating the ... -
The flavagline FL3 interferes with the association of Annexin A2 with the eIF4F initiation complex and transiently stimulates the translation of annexin A2 mRNA
(Journal article; Peer reviewed, 2023-05-12)Introduction: Annexin A2 (AnxA2) plays a critical role in cell transformation, immune response, and resistance to cancer therapy. Besides functioning as a calcium- and lipidbinding protein, AnxA2 also acts as an mRNA-binding ... -
In vivo environment swiftly restricts human pancreatic progenitors toward mono-hormonal identity via a HNF1A/HNF4A mechanism
(Journal article; Peer reviewed, 2020)Generating insulin-producing β-cells from human induced pluripotent stem cells is a promising cell replacement therapy for improving or curing insulin-dependent diabetes. The transplantation of end-stages differentiating ... -
Mitochondrial respiratory chain dysfunction—A hallmark pathology of idiopathic Parkinson’s disease?
(Journal article; Peer reviewed, 2022)Parkinson’s disease (PD) is the most common age-dependent neurodegenerative synucleinopathy. Loss of dopaminergic neurons of the substantia nigra pars compacta, together with region- and cell-specific aggregations of ... -
The neutral amino acid transporter SLC7A10 in adipose tissue, obesity and insulin resistance
(Journal article; Peer reviewed, 2022)Obesity, insulin resistance and type 2 diabetes represent major global health challenges, and a better mechanistic understanding of the altered metabolism in these conditions may give improved treatment strategies. SLC7A10, ... -
A New Look at the Functional Organization of the Golgi Ribbon
(Peer reviewed; Journal article, 2019-08-21)A characteristic feature of vertebrate cells is a Golgi ribbon consisting of multiple cisternal stacks connected into a single-copy organelle next to the centrosome. Despite numerous studies, the mechanisms that link the ... -
Nicotinamide Riboside and Metformin Ameliorate Mitophagy Defect in Induced Pluripotent Stem Cell-Derived Astrocytes With POLG Mutations
(Journal article; Peer reviewed, 2021)Mitophagy specifically recognizes and removes damaged or superfluous mitochondria to maintain mitochondrial homeostasis and proper neuronal function. Defective mitophagy and the resulting accumulation of damaged mitochondria ... -
RNA-binding is an ancient trait of the Annexin family
(Journal article; Peer reviewed, 2023)Introduction: The regulation of intracellular functions in mammalian cells involves close coordination of cellular processes. During recent years it has become evident that the sorting, trafficking and distribution of ... -
Starvation to Glucose Reprograms Development of Neurovascular Unit in Embryonic Retinal Cells
(Journal article; Peer reviewed, 2021)Perinatal exposure to starvation is a risk factor for development of severe retinopathy in adult patients with diabetes. However, the underlying mechanisms are not completely understood. In the present study, we shed light ...