Browsing Department of Biomedicine by Title
Now showing items 224-243 of 753
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An electrophysiological study in freely exploring rats - Place cell properties and place field stability in the absence or presence of reward as a motivational factor.
(Master thesis, 2009-06-02)The activity of pyramidal cells in the hippocampus can be spatially modulated. Numerous studies have been performed examining their properties, like what influences the position of their firing fields or what effect changes ... -
Electrotonic signal processing in AII amacrine cells: compartmental models and passive membrane properties for a gap junction-coupled retinal neuron
(Peer reviewed; Journal article, 2018-09)Amacrine cells are critical for processing of visual signals, but little is known about their electrotonic structure and passive membrane properties. AII amacrine cells are multifunctional interneurons in the mammalian ... -
Elevated body weight modulates subcortical volume change and associated clinical response following electroconvulsive therapy
(Journal article; Peer reviewed, 2021)Background: Obesity is a frequent somatic comorbidity of major depression, and it has been associated with worse clinical outcomes and brain structural abnormalities. Converging evidence suggests that electroconvulsive ... -
Elevated CD3+ and CD8+ tumor-infiltrating immune cells correlate with prolonged survival in glioblastoma patients despite integrated immunosuppressive mechanisms in the tumor microenvironment and at the systemic level
(Peer reviewed; Journal article, 2013-11-15)We characterized GBM patients' tumor and systemic immune contexture with aim to reveal themechanisms of immunological escape, their impact on patient outcome, and identify targets for immunotherapy. Increased CD3+ T-cell ... -
Elucidating tumour-associated microglia/macrophage diversity along glioblastoma progression and under ACOD1 deficiency
(Journal article; Peer reviewed, 2022)In glioblastoma (GBM), tumour-associated microglia/macrophages (TAMs) represent the major cell type of the stromal compartment and contribute to tumour immune escape mechanisms. Thus, targeting TAMs is emerging as a promising ... -
Enhanced cognitive function and antidepressant-like effects after krill oil supplementation in rats
(Peer reviewed; Journal article, 2013-01-25)Background: The purpose of the study was to evaluate the effects of krill oil (KO) on cognition and depression-like behaviour in rats. Methods: Cognition was assessed using the Aversive Light Stimulus Avoidance Test (ALSAT). ... -
Enhanced gene expression from retroviral vectors
(Peer reviewed; Journal article, 2008-02-25)Background: Retroviruses are widely used to transfer genes to mammalian cells efficiently and stably. However, genetic elements required for high-level gene expression are incompatible with standard systems. The retroviral ... -
Enhanced protein synthesis and secretion using a rational signal-peptide library approach as a tailored tool
(Peer reviewed; Journal article, 2011-11-22) -
Epac1 Is Crucial for Maintenance of Endothelial Barrier Function through A Mechanism Partly Independent of Rac1
(Journal article; Peer reviewed, 2020)Epac1 (exchange protein activated by cAMP) stabilizes the endothelial barrier, but detailed studies are limited by the side effects of pharmacological Epac1 modulators and transient transfections. Here, we compare the key ... -
Epac1 null mice have nephrogenic diabetes insipidus with deficient corticopapillary osmotic gradient and weaker collecting duct tight junctions
(Journal article; Peer reviewed, 2020)Aim The cAMP‐mediator Epac1 (RapGef3) has high renal expression. Preliminary observations revealed increased diuresis in Epac1−/− mice. We hypothesized that Epac1 could restrict diuresis by promoting transcellular collecting ... -
Epac1-deficient mice have bleeding phenotype and thrombocytes with decreased GPIbβ expression
(Peer reviewed; Journal article, 2017)Epac1 (Exchange protein directly activated by cAMP 1) limits fluid loss from the circulation by tightening the endothelial barrier. We show here that Epac1−/− mice, but not Epac2−/− mice, have prolonged bleeding time, ... -
Epistatic and gene wide effects in YWHA and aromatic amino hydroxylase genes across ADHD and other common neuropsychiatric disorders: Association with YWHAE
(Peer reviewed; Journal article, 2015-09)Monoamines critically modulate neurophysiological functions affected in several neuropsychiatric disorders. We therefore examined genes encoding key enzymes of catecholamine and serotonin biosynthesis (tyrosine and tryptophan ... -
Epithelial to mesenchymal transition (EMT) is associated with attenuation of succinate dehydrogenase (SDH) in breast cancer through reduced expression of SDHC
(Peer reviewed; Journal article, 2019-06-01)Background: Epithelial to mesenchymal transition (EMT) is a well-characterized process of cell plasticity that may involve metabolic rewiring. In cancer, EMT is associated with malignant progression, tumor heterogeneity, ... -
Equilibrative Nucleoside Transporters Mediate the Import of Nicotinamide Riboside and Nicotinic Acid Riboside into Human Cells
(Journal article; Peer reviewed, 2021)Nicotinamide riboside (NR), a new form of vitamin B3, is an effective precursor of nicotinamide adenine dinucleotide (NAD+) in human and animal cells. The introduction of NR into the body effectively increases the level ... -
Esmolol added in repeated, cold, oxygenated blood cardioplegia improves myocardial function after cardiopulmonary bypass
(Peer reviewed; Journal article, 2015-06)Objective: This study investigated if the β-receptor blocking agent esmolol, added to standard oxygenated blood cardioplegia, improved myocardial function after weaning from bypass. Design: A block-randomized, blinded ... -
Essential Features and Use Cases of the Cerebrospinal Fluid Proteome Resource (CSF-PR)
(Peer reviewed; Journal article, 2019)Every year, a large number of published studies present biomarkers for various neurological disorders. Many of these studies are based on mass spectrometry proteomics data and describe comparison of the abundance of proteins ... -
EU-OPENSCREEN: A novel collaborative approach to facilitate chemical biology
(Peer reviewed; Journal article, 2019)Compound screening in biological assays and subsequent optimization of hits is indispensable for the development of new molecular research tools and drug candidates. To facilitate such discoveries, the European Research ... -
Evaluating Extracellular Matrix influence on adherent cell signaling by Cold Trypsin Phosphorylation-specific Flow Cytometry
(Peer reviewed; Journal article, 2013-08-19)Background: Tissue microenvironments comprise different extracellular matrix (ECM) proteins that regulate cellular responsiveness to growth factors. In vitro culture of adherent cells on ECM-coated substrata is commonly ... -
Evaluation of Prebiotic and Probiotic Effects on the Intestinal Gut Microbiota and Histology of Atlantic salmon (Salmo salar L.)
(Peer reviewed; Journal article, 2011)In the present study the impact on gut microbiology and indigenous gut histology of Atlantic salmon (Salmo salar L.) was investigated following feeding of a control and a prebiotic (EWOS prebiosal®) diet and ex vivo exposure ... -
Event-related-potential (ERP) correlates of performance monitoring in adults with attention-deficit hyperactivity disorder (ADHD)
(Peer reviewed; Journal article, 2018-04-11)Introduction: Attention-deficit hyperactivity disorder (ADHD) is one of the most frequent neurodevelopmental disorders in children and tends to persist into adulthood. Evidence from neuropsychological, neuroimaging, and ...