Browsing Department of Biomedicine by Document Types "Master thesis"
Now showing items 61-80 of 90
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Oral microbiome in a general population - The influence of sample site and sampling method
(Master thesis, 2023-08-02)Oral microbiome profiles reflect the sample types and methodology used to investigate them. The composition of microbes in the oral cavity is site specific. It can also vary due to differences in how a site is sampled. ... -
Pharmacological targeting of the Treg/Th17 axis using in vitro cell cultures derived from patients with autoimmune Addison's disease
(Master thesis, 2022-06-01)Autoimmune Addison’s disease (AAD) is a rare endocrine disorder characterized by an immune-mediated attack towards the cells of the adrenal cortex. The major self-antigen, targeted by autoantibodies and self-reactive T ... -
POU3f2 in human gliomas - Expression pattern and functional role
(Master thesis, 2014-06-02)Gliomas are tumors of the central nervous system (CNS). They are responsible for about 28% of all central nervous system tumors and for 80% of all malignant brain tumors. The most commonly used classification and grading ... -
Preparing for an influenza pandemic: Re-evaluating the use of the whole inactivated virus vaccine formulation. –A comparison of the immune responses after intramuscular or intranasal immunization with an influenza H5N1 whole inactivated virus vaccine in a murine model.
(Master thesis, 2009-10-22)Influenza is a highly contagious respiratory disease which infects millions of people every year around the world. Influenza viruses undergo continuous antigen change and annual vaccination is an effective prophylactic ... -
Proteomic analysis of neonatal meningitis-causing Escherichia coli
(Master thesis, 2017-11-30)Meningitis in newborns is a serious infection that causes mortality and neurological injury worldwide. The infection progresses from sepsis, and is dependent on the pathogen being able to cross the blood-brain barrier and ... -
Regulation and function of tumor suppressor p53 isoforms beta and gamma in Acute Myeloid Leukemia
(Master thesis, 2013-06-01)Research has proposed that the C-terminal truncated p53 isoforms beta and gamma enhance chemosensitivity in p53(null) cancer cell lines. Their high expression in acute myeloid leukemia (AML) patients correlates positively ... -
The role of autoantibodies in cell mediated autoimmune Addison`s disease
(Master thesis, 2012-05-31)Background: Addison`s disease (primary adrenal insufficiency) is a prototypic organ-specific autoimmune disease affecting the adrenal cortex. Autoimmune Addison`s disease (AAD) is often characterized by autoantibodies ... -
The Role of Axl in Cancer and Stem Cell Plasticity: in vivo Lineage Tracing and Imaging Mass Cytometry Analysis
(Master thesis, 2019-11-14) -
The role of Axl in melanoma metastasis
(Master thesis, 2015-05-31)Melanoma is a highly invasive and metastatic cancer, thus understanding the mechanism of melanoma metastasis is a major issue. In our study, the objective is to elucidate the role of the receptor tyrosine kinase Axl in ... -
Role of Caveolin-1 in Hypoxia and Proneural to Mesenchymal Transition of Glioblastoma
(Master thesis, 2018-06-29)Glioblastomas (GBM), a grade IV astrocytoma, is the most common and aggressive primary brain tumors in adults, associated with short survival and uniformly fatal outcome irrespective of treatment. GBM is highly heterogeneous ... -
Role of mechanotransduction in pancreatic endocrine cell fate acquisition in SC-islets
(Master thesis, 2024-06-03) -
The role of pyruvate dehydrogenase kinases (PDKs) in rewiring of cell metabolism under energy stress
(Master thesis, 2019-06-28)Irregularities in cellular energy metabolism have been linked to many human diseases, including metabolic disorders, mitochondrial diseases, cancer, and neurodegeneration. In order to survive and function properly, an ... -
The role of the intermediate compartment in membrane traffic during different stages of the cell cycle
(Master thesis, 2011-06-01)The biosynthetic-secretory pathway delivers newly synthesized molecules from the endoplasmic reticulum (ER) to the plasma membrane (PM), as well as to endomembrane compartments. The intermediate compartment (IC) is an ... -
Sensing foul AIRE: Investigating possible reporter genes for AIRE mutations
(Master thesis, 2018-06-29)The autoimmune regulator protein, known as AIRE, is a potent transcriptional regulator active in medullary thymic epithelial cells (mTECs) of the thymus, where it is able to switch on the expression of thousands of genes ... -
Single cell analysis of signal transduction in hematopoietic stem and progenitor cells from healthy donors
(Master thesis, 2014-02-28)The thesis has the title Single cell analysis of signal transduction in hematopoietic stem and progenitor cells from healthy donors". Flow cytometry enables complex biochemical signaling networks to be determined in ... -
Stedcellenes fyringsmønster under påvirkning av belønning og forsøksapparatets geometri
(Master thesis, 2004)I hippocampus hos rotter finner man en type nerveceller som aktiveres stedspesifikt. Dette innebærer at de kun er aktive når rotten er i et bestemt område av omgivelsene. Disse cellene kalles stedceller (en: "place cells") ... -
Structure-based design of pantothenate kinase inhibitors as lead structures for new antibiotics
(Master thesis, 2020-06-23) -
Targeting the AKT Pathway in Glioblastoma Multiforme
(Master thesis, 2016-06-01)In this study, the therapeutic efficacy of AKT allosteric and ATP competitive inhibitors was investigated in EGFR-amplified SKMG-3 and EGFR-low U-87 cell lines. The IC50 values of AKT inhibitors were determined by cellular ...