Blar i Department of Biomedicine på tittel
Viser treff 737-753 av 753
-
Use of stable isotope dimethyl labeling coupled to selected reaction monitoring to enhance throughput by multiplexing relative quantitation of targeted proteins
(Peer reviewed; Journal article, 2012)In this manuscript, we present a proof-of-concept study for targeted relative protein quantitation workflow using chemical labeling in the form of dimethylation, coupled with selected reaction monitoring (dimethyl-SRM). ... -
Using iPSC-derived cortical organoids to study disease mechanisms of POLG-disease and explore new therapeutic strategies
(Master thesis, 2023-07-03)POLG-related diseases are a set of severe mitochondrial myopathies caused by a mutation in the POLG gene. The POLG gene encodes for the catalytic subunit of the mitochondrial DNA (mtDNA) polymerase gamma (Pol-γ). Pol-γ is ... -
Using mass spectrometry-based proteomics to improve the understanding of multiple sclerosis treatments
(Doctoral thesis, 2021-06-23)In this work, the effects of multiple sclerosis (MScl) treatments were investigated by quantitative proteomics. First, the effects of the anti-inflammatory drug Fingolimod was studied to see if the drug affected central ... -
Validity and accuracy of the Adult Attention-Deficit/Hyperactivity Disorder (ADHD) Self-Report Scale (ASRS) and the Wender Utah Rating Scale (WURS) symptom checklists in discriminating between adults with and without ADHD
(Journal article; Peer reviewed, 2020)Objective To validate the Adult ADHD Self‐Report Scale (ASRS) and the Wender Utah Rating Scale (WURS) in a well‐characterized sample of adult attention‐deficit/hyperactivity disorder (ADHD) patients and population ... -
Valtrate, an iridoid compound in Valeriana, elicits anti-glioblastoma activity through inhibition of the PDGFRA/MEK/ERK signaling pathway
(Journal article; Peer reviewed, 2023)Background Valtrate, a natural compound isolated from the root of Valeriana, exhibits antitumor activity in many cancers through different mechanisms. However, its efficacy for the treatment of glioblastoma (GBM), a ... -
Vascular endothelial growth factors and receptors - from normal dental pulp to apical pathology
(Doctoral thesis, 2016-02-12)The VEGFs -A, -B, -C, -D are important signaling molecules with pivotal implication in the growth of blood and lymphatic vessels, the so-called angio- and lymphangiogenesis. They exert their activities by binding to their ... -
VEGF-B hypertrophy predisposes to transition from diastolic to systolic heart failure in hypertensive rats
(Journal article; Peer reviewed, 2023)Aims: Cardiac energy metabolism is centrally involved in heart failure (HF), although the direction of the metabolic alterations is complex and likely dependent on the particular stage of HF progression. Vascular endothelial ... -
Viewing the proteome: How to visualize proteomics data?
(Peer reviewed; Journal article, 2015-04)Proteomics has become one of the main approaches for analyzing and understanding biological systems. Yet similar to other high-throughput analysis methods, the presentation of the large amounts of obtained data in easily ... -
Virtual Source Modelling of Photon Beams for Monte Carlo Based Radiation Therapy Treatment Planning
(Doctoral thesis, 2011-10-13)Modern radiotherapy (RT) techniques such as stereotactic body radiotherapy (SBRT), intensitymodulated radiotherapy (IMRT) or volumetric modulated arc therapy (VMAT) carries the potential of improving the quality of treatment. ... -
Visualization of metastatic melanoma cells by fluorescence microscopy and MRI using a novel glycogen nanoprobe
(Master thesis, 2014-06-05)The incidence of malignant melanoma has increased steadily during the last decades. Large portions of individuals with this particular skin cancer develop multiple brain metastases, which is associated with a particular ... -
Voxel dimension optimization for probabilistic tractography in rat brain using 7T scanner
(Master thesis, 2015-06-01)Brain connectivity is an increasingly important research field within neuroscience. Using MRI technology it is now possible to measure diffusion to approximate the location of anatomical tracts in the brain or correlate ... -
Welcome to the Family: Identification of the NAD+ Transporter of Animal Mitochondria as Member of the Solute Carrier Family SLC25
(Journal article; Peer reviewed, 2021)Subcellular compartmentation is a fundamental property of eukaryotic cells. Communication and metabolic and regulatory interconnectivity between organelles require that solutes can be transported across their surrounding ... -
Widespread promoter methylation of synaptic plasticity genes in long-term potentiation in the adult brain in vivo.
(Peer reviewed; Journal article, 2017-03-23)Background: DNA methylation is a key modulator of gene expression in mammalian development and cellular differentiation, including neurons. To date, the role of DNA modifications in long-term potentiation (LTP) has not ... -
Work participation in ADHD and associations with social characteristics, education, lifetime depression, and ADHD symptom severity
(Peer reviewed; Journal article, 2019-06)The literature refers to high rates of occupational failure in the population of adults with ADHD. The explanation for this is less known. The aim of the present study was to examine associations between social characteristics ... -
The World Federation of ADHD International Consensus Statement: 208 Evidence-based conclusions about the disorder
(Journal article; Peer reviewed, 2021)Background Misconceptions about ADHD stigmatize affected people, reduce credibility of providers, and prevent/delay treatment. To challenge misconceptions, we curated findings with strong evidence base. Methods We ... -
XAB2 promotes Ku eviction from single-ended DNA double-strand breaks independently of the ATM kinase
(Journal article; Peer reviewed, 2021)Replication-associated single-ended DNA double-strand breaks (seDSBs) are repaired predominantly through RAD51-mediated homologous recombination (HR). Removal of the non-homologous end-joining (NHEJ) factor Ku from resected ... -
α11β1 integrin is induced in a subset of cancer- associated fibroblasts in desmoplastic tumor stroma and mediates in vitro cell migration
(Peer reviewed; Journal article, 2019-06-01)Integrin α11β1 is a collagen receptor that has been reported to be overexpressed in the stroma of non-small cell lung cancer (NSCLC) and of head and neck squamous cell carcinoma (HNSCC). In the current study, we further ...