Blar i Department of Clinical Medicine på forfatter "Akslen, Lars A."
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Inverse correlation between PDGFC expression and lymphocyte infiltration in human papillary thyroid carcinoma
Bruland, Ove; Fluge, Øystein; Akslen, Lars A.; Eiken, Hans Geir; Lillehaug, Johan; Varhaug, Jan Erik; Knappskog, Per (Peer reviewed; Journal article, 2009-12-08)Background: Members of the PDGF family have been suggested as potential biomarkers for papillary thyroid carcinomas (PTC). However, it is known that both expression and stimulatory effect of PDGF ligands can be affected ... -
Ki-67 expression is superior to mitotic count and novel proliferation markers PHH3, MCM4 and mitosin as a prognostic factor in thick cutaneous melanoma
Ladstein, Rita Grude; Bachmann, Ingeborg M.; Straume, Oddbjørn; Akslen, Lars A. (Peer reviewed; Journal article, 2010-04-14)Background: Tumor cell proliferation is a predictor of survival in cutaneous melanoma. The aim of the present study was to evaluate the prognostic impact of mitotic count, Ki-67 expression and novel proliferation markers ... -
KRAS gene amplification and overexpression but not mutation associates with aggressive and metastatic endometrial cancer
Birkeland, Even; Wik, Elisabeth; Mjøs, Siv; Høivik, Erling Andre; Trovik, Jone; Werner, Henrica Maria Johanna; Kusonmano, Kanthida; Petersen, Kjell; Ræder, Maria B.; Holst, Frederik; Øyan, Anne Margrete; Kalland, Karl-Henning; Akslen, Lars A.; Simon, Ronald; Krakstad, Camilla; Salvesen, Helga Birgitte (Peer reviewed; Journal article, 2012)BACKGROUND: Three quarter of endometrial carcinomas are treated at early stage. Still, 15 to 20% of these patients experience recurrence, with little effect from systemic therapies. Homo sapiens v-Ki-ras2 Kirsten rat sarcoma ... -
Lipocalin 2 expression is associated with aggressive features of endometrial cancer
Mannelqvist, Monica; Stefansson, Ingunn; Wik, Elisabeth; Kusonmano, Kanthida; Ræder, Maria B.; Øyan, Anne Margrete; Kalland, Karl-Henning; Moses, Marsha A.; Salvesen, Helga Birgitte; Akslen, Lars A. (Peer reviewed; Journal article, 2012-05-06)Background: Increased expression of lipocalin 2 (LCN2) has been observed in several cancers. The aim of the present study was to investigate LCN2 in endometrial cancer in relation to clinico-pathologic phenotype, angiogenesis, ... -
Mammographic density and histopathologic characteristics of screen-detected tumors in the Norwegian Breast Cancer Screening Program
Moshina, Nataliia; Ursin, Giske; Hoff, Solveig Roth; Akslen, Lars A.; Roman, Marta; Sebuødegård, Sofie; Hofvind, Solveig (Peer reviewed; Journal article, 2015-09-18)Background. High mammographic density might mask breast tumors, resulting in delayed diagnosis or missed cancers. Purpose. To investigate the association between mammographic density and histopathologic tumor characteristics ... -
Metabolic consequences of perioperative oral carbohydrates in breast cancer patients - an explorative study
Lende, Tone Hoel; Austdal, Marie; Bathen, Tone Frost; Varhaugvik, Anne Elin; Skaland, Ivar; Gudlaugsson, Einar; Egeland, Nina Gran; Lunde, Siri; Akslen, Lars A.; Jonsdottir, Kristin; Janssen, Emiel; Søiland, Håvard; Baak, Jan P.A. (Peer reviewed; Journal article, 2019-12-04)Background: The metabolic consequences of preoperative carbohydrate load in breast cancer patients are not known. The present explorative study investigated the systemic and tumor metabolic changes after preoperative ... -
Microvascular proliferation in luminal Aand basal-like breast cancer subtypes
Kraby, Maria Ryssdal; Krüger, Kristi; Opdahl, Signe; Vatten, Lars Johan; Akslen, Lars A.; Bofin, Anna M. (Peer reviewed; Journal article, 2015)Aims: The aims of this study were to examine microvessel density (MVD), proliferating MVD (pMVD) and Vascular Proliferation Index (VPI) in basal-like phenotype (BP) and luminal A subtypes of breast cancer and to study their ... -
Microvascular proliferation is associated with aggressive tumour features and reduced survival in lung adenocarcinoma
Ramnefjell, Maria; Aamelfot, Christina; Aziz, Sura Mohammed; Helgeland, Lars; Akslen, Lars A. (Peer reviewed; Journal article, 2017-10)Despite new treatment options in lung cancer, there is still a need for better biomarkers to assist in therapy decisions. Angiogenesis has been associated with tumour growth and dissemination, and the vascular proliferation ... -
Molecular Subtypes of Breast Cancer: Long-term Incidence Trends and Prognostic Differences
Valla, Marit; Vatten, Lars Johan; Engstrøm, Monica J; Haugen, Olav Anton; Akslen, Lars A.; Bjørngaard, Johan Håkon; Hagen, Anne Irene; Ytterhus, Borgny; Bofin, Anna M.; Opdahl, Signe (Peer reviewed; Journal article, 2016-12)Background: Secular trends in incidence and prognosis of molecular breast cancer subtypes are poorly described. We studied long-term trends in a population of Norwegian women born 1886–1977. Methods: A total of 52,949 women ... -
Molecular subtypes, histopathological grade and survival in a historic cohort of breast cancer patients
Engstrøm, Monica J; Opdahl, Signe; Hagen, Anne Irene; Romundstad, Pål Richard; Akslen, Lars A.; Haugen, Olav A.; Vatten, Lars Johan; Bofin, Anna M. (Peer reviewed; Journal article, 2013-08)Molecular subtyping of breast cancer may provide additional prognostic information regarding patient outcome. However, its clinical significance remains to be established. In this study, the main aims were to discover ... -
Polymorphisms in hormone metabolism and growth factor genes and mammographic density in Norwegian postmenopausal hormone therapy users and non-users
Ellingjord-Dale, Merete; Lee, Eunjung; Couto, Elisabeth; Ozhand, Ali; Qureshi, Samera Azeem; Hofvind, Solveig; Van Den Berg, David J.; Akslen, Lars A.; Grotmol, Tom; Ursin, Giske (Peer reviewed; Journal article, 2012-10-27)Introduction: Mammographic density (MD) is one of the strongest known breast cancer risk factors. Estrogen and progestin therapy (EPT) has been associated with increases in MD. Dense breast tissue is characterized by ... -
A positive Real-Time Elastography (RTE) combined with a Prostate Cancer Gene 3 (PCA3) score above 35 convey a high probability of intermediate- or high-risk prostate cancer in patient admitted for primary prostate biopsy
Nygård, Yngve; Haukaas, Svein A.; Halvorsen, Ole J.; Gravdal, Karsten; Frugård, Jannicke; Akslen, Lars A.; Beisland, Christian (Peer reviewed; Journal article, 2016-07-08)Background: The standard of care in patients with suspected prostate cancer (PCa) is systematic prostate biopsies. This approach leads to unnecessary biopsies in patients without PCa and also to the detection of clinical ... -
Post-PET ultrasound improves specificity of 18F-FDG-PET for recurrent differentiated thyroid cancer while maintaining sensitivity
Biermann, Martin; Kråkenes, Jostein; Brauckhoff, Katrin; Haugland, Hans Kristian; Akslen, Lars A.; Heinecke, A.; Varhaug, Jan Erik; Brauckhoff, Michael (Peer reviewed; Journal article, 2015-03-13)Background: Positron emission tomography (PET) using fluor-18-deoxyglucose (18F-FDG) with or without computed tomography (CT) is generally accepted as the most sensitive imaging modality for diagnosing recurrent differentiated ... -
Predictive value of angiogenic proteins in patients with metastatic melanoma treated with bevacizumab monotherapy
Schuster, Cornelia; Akslen, Lars A.; Stokowy, Tomasz; Straume, Oddbjørn (Peer reviewed; Journal article, 2019)The incidence of malignant melanoma is rising worldwide and survival for metastatic disease is still poor. Recently, new treatment options have become available. Still, predictive biomarkers are needed to optimise treatment ... -
Prognostic value of uPAR expression and angiogenesis in primary and metastatic melanoma
Hugdahl, Emilia Signe; Bachmann, Ingeborg M.; Schuster, Cornelia; Ladstein, Rita Grude; Akslen, Lars A. (Peer reviewed; Journal article, 2019-01-14)Angiogenesis is important for the progression of cutaneous melanoma. Here, we analyzed the prognostic impact of the angiogenic factor urokinase plasminogen activator resecptor (uPAR), vascular proliferation index (VPI) and ... -
Quantifying tumour vascularity in non-luminal breast cancers
Kraby, Maria Ryssdal; Opdahl, Signe; Akslen, Lars A.; Bofin, Anna M. (Peer reviewed; Journal article, 2017)Aims: Microvessel density (MVD), proliferating MVD (pMVD) and vascular proliferation index (VPI) are methods used to quantify tumour vascularity in histopathological sections. In this study, we assessed MVD, pMVD and VPI ... -
Subtyping of breast cancer by immunohistochemistry to investigate a relationship between subtype and short and long term survival: a collaborative analysis of data for 10,159 cases from 12 studies
Schmidt, Marjanka K.; Leeuwen, Flora E. van; Wesseling, Jelle; Cheang, Maggie C. U.; Gelmon, Karen; Nielsen, Torsten O.; Blomqvist, Carl; Heikkilä, Päivi; Heikkinen, Tuomas; Broeks, Annegien; Nevanlinna, Heli; Akslen, Lars A.; Bégin, Louis R.; Foulkes, William D.; Couch, Fergus J.; Wang, Xianshu; Cafourek, Vicky; Olson, Janet E.; Baglietto, Laura; Giles, Graham G.; Severi, Gianluca; McLean, Catriona A.; Southey, Melissa C.; Rakha, Emad; Green, Andrew R.; Ellis, Ian O.; Sherman, Mark E.; Lissowska, Jolanta; Anderson, William F.; Cox, Angela; Cross, Simon S.; Reed, Malcolm W. R.; Provenzano, Elena; Dawson, Sarah-Jane; Dunning, Alison M.; Humphreys, Manjeet; Easton, Douglas F.; García-Closas, Montserrat; Caldas, Carlos; Pharoah, Paul D.; Huntsman, David G.; Blows, Fiona M.; Driver, Kristy E. (Peer reviewed; Journal article, 2010-05-25)Background Immunohistochemical markers are often used to classify breast cancer into subtypes that are biologically distinct and behave differently. The aim of this study was to estimate mortality for patients with the ... -
Terminal digit preference: a source of measurement error in breast cancer diameter reporting
Tsuruda, Kaitlyn; Hofvind, Solveig; Akslen, Lars A.; Hoff, Solveig Roth; Veierød, Marit Bragelien (Peer reviewed; Journal article, 2019)Objectives: Women diagnosed with breast cancer are offered treatment and therapy based on tumor characteristics, including tumor diameter. There is scarce knowledge whether tumor diameter is accurately reported, or whether ... -
Tumor necrosis is associated with increased alphav beta3 integrin expression and poor prognosis in nodular cutaneous melanomas
Bachmann, Ingeborg M.; Ladstein, Rita Grude; Straume, Oddbjørn; Naumov, George N.; Akslen, Lars A. (Peer reviewed; Journal article, 2008-12-05)Background: Tumor necrosis and apoptotic activity are considered important in cancer progression, but these features have not been much studied in melanomas. Our hypothesis was that rapid growth in cutaneous melanomas of ... -
Two-view digital breast tomosynthesis versus digital mammography in a population-based breast cancer screening programme (To-Be): a randomised, controlled trial
Hofvind, Solveig; Holen, Åsne Sørlien; Aase, Hildegunn Siv; Houssami, Nehmat; Sebuødegård, Sofie; Moger, Tron Anders; Haldorsen, Ingfrid S.; Akslen, Lars A. (Peer reviewed; Journal article, 2019)Background: Digital breast tomosynthesis is an advancement of mammography, and has the potential to overcome limitations of standard digital mammography. This study aimed to compare first-generation digital breast ...