Browsing Department of Clinical Medicine by Author "Ditzel, Henrik J."
Now showing items 1-1 of 1
-
Intrinsic Differences in Spatiotemporal Organization and Stromal Cell Interactions Between Isogenic Lung Cancer Cells of Epithelial and Mesenchymal Phenotypes Revealed by High-Dimensional Single-Cell Analysis of Heterotypic 3D Spheroid Models
Lotsberg, Maria Lie; Røsland, Gro Vatne; Rayford, Austin James; Dyrstad, Sissel Elisabeth; Ekanger, Camilla Tvedt; Lu, Ning; Frantz, Kirstine; Stuhr, Linda Elin Birkhaug; Ditzel, Henrik J.; Thiery, Jean Paul; Akslen, Lars Andreas; Lorens, James; Engelsen, Agnete (Journal article; Peer reviewed, 2022)The lack of inadequate preclinical models remains a limitation for cancer drug development and is a primary contributor to anti-cancer drug failures in clinical trials. Heterotypic multicellular spheroids are three-dimensional ...