Blar i Department of Clinical Medicine på forfatter "Aarstad, Hans Jørgen"
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Associations between nasal characteristics and sleep polygraphic data in patients suspected Obstructive Sleep Apnea
Hoven, Kristin Marie; Aarstad, Hans Jørgen; Steinsvåg, Sverre Karmhus (Journal article; Peer reviewed, 2020)Background: The aim of the present study was to explore the relationships between Obstructive Sleep Apnea (OSA), daytime sleepiness, nasal geometry, nasal airflow, and patient- reported sino-nasal symptoms. Methodology: ... -
Chemokines are secreted by monocytes following OK-432 (lyophilized Streptococcus pyogenes) stimulation
Olsnes, Carla; Stavang, Helen Åse Margrethe; Brokstad, Karl Albert; Olofsson, Jan; Aarstad, Hans Jørgen (Peer reviewed; Journal article, 2009-01-28)Background: OK-432, penicillin-killed Streptococcus pyogenes, is used in treating lymphangiomas and carcinomas. We have studied in vitro the role of mononuclear phagocytes (MNPs), including purified monocytes (MOs), in the ... -
Choice of psychological coping in laryngectomized, head and neck squamous cell carcinoma patients versus multiple sclerosis patients
Aarstad, Anne Kari Hersvik; Lode, Kirsten; Larsen, Jan Petter; Bru, Edvin; Aarstad, Hans Jørgen (Peer reviewed; Journal article, 2010-11-18)To be treated for cancer must be a frightening experience. Yet quality of life (QoL) of successfully treated cancer patients seems to be relatively similar in comparison with QoL of a general population, with psychological ... -
Exercise-induced laryngeal obstruction: natural history and effect of surgical treatment
Maat, Robert Christiaan; Hilland, Magnus; Røksund, Ola Drange; Halvorsen, Thomas; Olofsson, Jan; Aarstad, Hans Jørgen; Heimdal, John-Helge (Peer reviewed; Journal article, 2011-06-05)The current follow-up study concerning the supraglottic type of exercise-induced laryngeal obstruction (EILO) was performed to reveal the natural history of supraglottic EILO and compare the symptoms, as well as the laryngeal ... -
An fMRI-study on single-sided deafness: Spectral-temporal properties and side of stimulation modulates hemispheric dominance
Heggdal, Peder Olaf Laugen; Aarstad, Hans Jørgen; Brännström, Jonas; Vassbotn, Flemming; Specht, Karsten (Peer reviewed; Journal article, 2019)Objective: Our main aim was to investigate the blood oxygenation level dependent (BOLD) response to monaural and binaural speech- and non-speech stimuli as measured with fMRI in subjects with single-sided deafness and in ... -
Generic Quality of Life in persons With Hearing Loss: A Systematic Litterature Review
Nordvik, Øyvind; Heggdal, Peder Olaf Laugen; Brännstrøm, Jonas; Vassbotn, Flemming; Aarstad, Anne Kari Hersvik; Aarstad, Hans Jørgen (Peer reviewed; Journal article, 2018-01-22)Background: To the best of our knowledge, no empirically based consensus has been reached as to if, and to what extent, persons with hearing loss (HL) have reduced generic Quality of life (QoL). There seems to be limited ... -
Hearing as an Independent Predictor of Postural Balance in 1075 Patients Evaluated for Dizziness
Berge, Jan Erik; Nordahl, Stein Helge; Aarstad, Hans Jørgen; Goplen, Frederik Kragerud (Journal article; Peer reviewed, 2019)Objective To evaluate the association between hearing and postural balance. Study Design Retrospective cross-sectional study. Setting Tertiary care otolaryngology clinic. Subjects and Methods Patients examined for ... -
Importance of personality and coping expectancy on patient-reported hearing disability, quality of life and distress level: a study of patients referred to an audiology service
Nordvik, Øyvind; Heggdal, Peder O Laugen; Brännström, K. Jonas; Aarstad, Anne Kari; Aarstad, Hans Jørgen (Journal article; Peer reviewed, 2021)Purpose: According to the World Health Organization (WHO), hearing loss (HL) affects up to 15% of the world’s adult population. Coping and personality are hypothesized to underlie quality of life (QoL) and distress scores. ... -
In vitro-stimulated IL-6 monocyte secretion and in vivo peripheral blood T lymphocyte activation uniquely predicted 15-year survival in patients with head and neck squamous cell carcinoma
Aarstad, Helene Hersvik; Vintermyr, Olav Karsten; Ulvestad, Elling; Kross, Kenneth Wilfried; Heimdal, John-Helge; Aarstad, Hans Jørgen (Peer reviewed; Journal article, 2015-06-16)The study was performed in order to determine whether peripheral blood monocyte in vitro function, and lymphocyte in vivo activation at diagnosis, was associated with HPV tumor infection status and 15-year survival in head ... -
The levels of IL-6 and soluble IL-33R are increased in the renal vein during surgery for clear cell renal cell carcinoma
Gudbrandsdottir, Gigja; Aarstad, Helene Hersvik; Hjelle, Karin Margrethe; Førde, Kristina; Reisæter, Lars Anders Rokne; Bostad, Leif; Aarstad, Hans Jørgen; Beisland, Christian (Journal article; Peer reviewed, 2021)Purpose The main aim was to map serum levels of IL-1/IL-6 family cytokines and relevant receptors from serum samples taken across treatment in patients with Renal Cell Carcinoma (RCC). Additionally, we explored the possible ... -
Long-Term Survival in 1,931 Patients With Dizziness: Disease- and Symptom-Specific Mortality
Berge, Jan Erik; Nordahl, Stein Helge Glad; Aarstad, Hans Jørgen; Goplen, Frederik Kragerud (Journal article; Peer reviewed, 2021)Objective: To evaluate mortality among patients referred for suspected vestibular disorder and to examine whether specific symptoms or disorders predict long-term survival among patients with dizziness or vertigo. Study ... -
Longevity of B-cell and T-cell responses after live attenuated influenza vaccination in children
Mohn, Kristin Greve-Isdahl; Bredholt, Geir; Brokstad, Karl Albert; Pathirana, Rishi; Aarstad, Hans Jørgen; Tøndel, Camilla; Cox, Rebecca Jane (Peer reviewed; Journal article, 2015-05-15)Background. The live attenuated influenza vaccine (LAIV) is the preferred vaccine for children, but the mechanisms behind protective immune responses are unclear, and the duration of immunity remains to be elucidated. This ... -
Maturation of monocyte derived dendritic cells with OK432 boosts IL-12p70 secretion and conveys strong T-cell responses
Hovden, Arnt-Ove; Karlsen, Marie; Jonsson, Roland; Aarstad, Hans Jørgen; Appel, Silke (Peer reviewed; Journal article, 2011-01-05)Background: Design of tumour specific immunotherapies using the patients’ own dendritic cells (DC) is a fast advancing scientific field. The functional qualities of the DC generated in vitro are critical, and today’s gold ... -
Reduced grey- and white matter volumes due to unilateral hearing loss following treatment for vestibular schwannoma
Heggdal, Peder Olaf Laugen; Larsen, Kristina S.; Brännström, Jonas; Aarstad, Hans Jørgen; Specht, Karsten (Journal article; Peer reviewed, 2020)Objective Previous studies of the consequences of unilateral hearing loss (UHL) on the functional-structural organization of the brain has included subjects with various degrees of UHL. We suggest that the consequences ... -
The Romberg sign, unilateral vestibulopathy, cerebrovascular risk factors, and long-term mortality in dizzy patients
Berge, Jan Erik; Goplen, Frederik Kragerud; Aarstad, Hans Jørgen; Storhaug, Tobias Andre; Nordahl, Stein Helge Glad (Journal article; Peer reviewed, 2022)Objectives: Describe the relationship between unsteadiness, canal paresis, cerebrovascular risk factors, and long-term mortality in patients examined for dizziness of suspected vestibular origin. Study design: Observational ... -
Serum levels of the IL-6 family of cytokines predict prognosis in renal cell carcinoma (RCC)
Gudbrandsdottir, Gigja; Aarstad, Helene Hersvik; Bostad, Leif; Hjelle, Karin; Aarstad, Hans Jørgen; Bruserud, Øystein; Tvedt, Tor Henrik Anderson; Beisland, Christian (Journal article; Peer reviewed, 2020)Purpose An improved understanding of RCC immunology should shed further light on RCC tumor biology. Our objective was to study to what extent serum levels of the IL-6 family of cytokines at diagnosis were relevant to ... -
Targeted Next-Generation Sequencing of Cancer-Related Genes in a Norwegian Patient Cohort With Head and Neck Squamous Cell Carcinoma Reveals Novel Actionable Mutations and Correlations With Pathological Parameters
Dongre, Harsh N.; Haave, Hilde; Fromreide, Siren; Erland, Fredrik Atteraas; Moe, Svein Erik Emblem; Dhayalan, Sophia Manueldas; Riis, Rasmus Kopperud; Sapkota, Dipak; Costea, Daniela Elena; Aarstad, Hans Jørgen; Vintermyr, Olav Karsten (Journal article; Peer reviewed, 2021)Background: Targeted next-generation sequencing (NGS) is increasingly applied in clinical oncology to advance personalized treatment. Despite success in many other tumour types, use of targeted NGS panels for assisting ... -
The TP53 Codon 72 Arginine Polymorphism Is Found with Increased TP53 Somatic Mutations in HPV(−) and in an Increased Percentage among HPV(+) Norwegian HNSCC Patients
Moe, Svein Erik Emblem; Erland, Fredrik Atteraas; Fromreide, Siren; Lybak, Stein; Brydøy, Marianne; Dongre, Harsh Nitin; Manueldas, Sophia; Costea, Daniela Elena; Vintermyr, Olav Karsten; Aarstad, Hans Jørgen (Journal article; Peer reviewed, 2023-06-26)Background: Somatic TP53 mutations are frequent in head and neck squamous cell carcinoma (HNSCC) and are important pathogenic factors. Objective: To study TP53 mutations relative to the presence of human papillomavirus ... -
Tumor HPV status, level of regulatory T cells and macrophage infiltration predict up to 20-year non-disease-specific survival in oropharynx squamous cell carcinoma patients
Haave, Hilde; Ljøkjel, Borghild; Lybak, Helene; Moe, Svein Erik Emblem; Berge, Jan Erik; Vintermyr, Olav Karsten; Helgeland, Lars; Aarstad, Hans Jørgen (Journal article; Peer reviewed, 2022)Oropharynx squamous cell carcinoma (OPSCC) is of special interest because human papilloma virus (HPV) and/or smoking cause this disease. Influxes of inflammatory cells into such tumors are known to vary with prognoses. ... -
Tumor infiltration levels of CD3, Foxp3 (+) lymphocytes and CD68 macrophages at diagnosis predict 5-year disease-specific survival in patients with oropharynx squamous cell carcinoma
Ljøkjel, Borghild; Haave, Hilde; Lybak, Stein; Vintermyr, Olav Karsten; Helgeland, Lars; Aarstad, Hans Jørgen (Journal article; Peer reviewed, 2022)Head and neck cancer (HNC) is the sixth most common cancer worldwide. Oropharyngeal (OP) cancers are of special interest because of possible underlying HPV infection which is tied to prognosis. Influxes of inflammatory ...