Browsing Department of Clinical Medicine by Author "Karlsen, Marie"
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The Bacterial Preparation OK432 Induces IL-12p70 Secretion in Human Dendritic Cells in a TLR3 Dependent Manner
Hovden, Arnt-Ove; Karlsen, Marie; Jonsson, Roland; Appel, Silke (Peer reviewed; Journal article, 2012-02-21)Dendritic cells (DC) used in therapeutic cancer immunotherapy have to be able to stimulate T cells resulting in an immune response that can efficiently target the cancer cells. One of the critical hurdles has been the lack ... -
Maturation of monocyte derived dendritic cells with OK432 boosts IL-12p70 secretion and conveys strong T-cell responses
Hovden, Arnt-Ove; Karlsen, Marie; Jonsson, Roland; Aarstad, Hans Jørgen; Appel, Silke (Peer reviewed; Journal article, 2011-01-05)Background: Design of tumour specific immunotherapies using the patients’ own dendritic cells (DC) is a fast advancing scientific field. The functional qualities of the DC generated in vitro are critical, and today’s gold ...