Browsing Department of Clinical Medicine by Author "LaBarge, Mark"
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Loss of epigenetic suppression of retrotransposons with oncogenic potential in aging mammary luminal epithelial cells
Senapati, Parijat; Miyano, Masaru; Sayaman, Rosalyn W.; Basam, Mudaser; Leung, Amy; LaBarge, Mark; Schones, Dustin E. (Journal article; Peer reviewed, 2023)A primary function of DNA methylation in mammalian genomes is to repress transposable elements (TEs). The widespread methylation loss that is commonly observed in cancer cells results in the loss of epigenetic repression ...