Blar i Department of Clinical Medicine på forfatter "Cairns, John Alexander"
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“Don’t Think Twice, It’s All Right”: Using Additional Data to Reduce Uncertainty Regarding Oncologic Drugs Provided Through Managed Access Agreements in England
Kang, Ji Yeon; Cairns, John Alexander (Journal article; Peer reviewed, 2022)Objectives The Cancer Drugs Fund (CDF) in England uses managed access agreements to facilitate additional data collection to address uncertainties identified in the appraisals of new drugs. This study reviews the uncertainties ... -
Exploring uncertainty and use of real-world data in the National Institute for Health and Care Excellence single technology appraisals of targeted cancer therapy
Kang, Ji Yeon; Cairns, John Alexander (Journal article; Peer reviewed, 2022)Objectives Dealing with uncertainty is one of the critical topics in health technology assessment. The greater decision uncertainty in appraisals, the less clear the clinical- and cost-effectiveness of the health technology. ... -
HSP27 Expression as a Novel Predictive Biomarker for Bevacizumab: is it Cost Effective?
Seo, Mikyung Kelly; Straume, Oddbjørn; Akslen, Lars A.; Cairns, John Alexander (Journal article; Peer reviewed, 2020)Background: Despite the extensive use of bevacizumab in a range of oncology indications, the US FDA revoked its approval for breast cancers, and multiple negative trials in several solid malignancies have been reported, ... -
Protocol for data extraction: how realworld data have been used in the National Institute for Health and Care Excellence appraisals of cancer therapy
Kang, Jiyeon; Cairns, John Alexander (Journal article; Peer reviewed, 2022)Introduction Due to the limitations of relying on randomised controlled trials, the potential benefits of real-world data (RWD) in enriching evidence for health technology assessment (HTA) are highlighted. Despite increased ... -
Quality of life among women with symptomatic, screen-detected, and interval breast cancer, and for women without breast cancer: a retrospective cross-sectional study from Norway
Moshina, Nataliia; Falk, Ragnhild Sørum; Botteri, Edoardo; Larsen, Marthe; Akslen, Lars Andreas; Cairns, John Alexander; Hofvind, Solveig (Journal article; Peer reviewed, 2021)Purpose: Breast cancers detected at screening need less aggressive treatment compared to breast cancers detected due to symptoms. The evidence on the quality of life associated with screen-detected versus symptomatic breast ... -
Why do some countries approve a cancer drug and others don’t?
Pujolras, Laia Maynou; Cairns, John Alexander (Peer reviewed; Journal article, 2015-06)The term drug reimbursement describes the policy system that determines whether or not a drug is entitled to reimbursement within the healthcare system. Countries make different decisions regarding which cancer treatments ...