Browsing Department of Clinical Medicine by Author "Nakken, Ola"

Now showing items 1-6 of 6

    • Assessing amyotrophic lateral sclerosis prevalence in Norway from 2009 to 2015 from compulsory nationwide health registers 

      Nakken, Ola; Lindstrøm, Jonas Christoffer; Tysnes, Ole-Bjørn; Holmøy, Trygve (Peer reviewed; Journal article, 2017)
      Objective: In Norway, diagnoses from specialist health care visits, drug prescriptions, and causes of deaths are registered in compulsory health registers. We aimed to determine amyotrophic lateral sclerosis (ALS) prevalence ...

    • BCG vaccination and multiple sclerosis risk: A Norwegian cohort study 

      Nakken, Ola; Aarseth, Jan Harald; Wergeland, Stig; Stigum, Hein; Meyer, Haakon Eduard; Holmøy, Trygve (Journal article; Peer reviewed, 2024)
      Introduction: Bacillus Calmette–Guérin (BCG) vaccination induces long-lasting effects on the adaptive and innate immune systems and prevents development of experimental autoimmune encephalomyelitis and possibly also ...

    • Genetic epidemiology of amyotrophic lateral sclerosis in Norway - a 2-year population based study 

      Olsen, Cathrine Goberg; Busk, Øyvind Løvold; Aanjesen, Tori Navestad; Alstadhaug, Karl Bjørnar; Bjørnå, Ingrid Kristine; Braathen, Geir Julius; Breivik, Kristin Lif; Demic, Natasha; Flemmen, Heidi Øyen; Hallerstig, Erika; HogenEsch, Ineke; Holla, Øystein Lunde; Jøntvedt, Anne Berit; Kampman, Margitta T.; Kleveland, Grethe; Kvernmo, Helene Ballo; Ljøstad, Unn; Maniaol, Angelina; Morsund, Åse Hagen; Nakken, Ola; Novy, Camilla; Rekand, Tiina; Schlüter, Katrin Ruth; Schuler, Stephan; Tveten, Kristian; Tysnes, Ole-Bjørn; Holmøy, Trygve; Høyer, Helle (Journal article; Peer reviewed, 2022)
      Background: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that affects motor neurons. In Europe, disease-causing genetic variants have been identified in 40-70% of familial ALS patients and approximately ...

    • Mortality trends of amyotrophic lateral sclerosis in Norway 1951–2014: an age–period–cohort study 

      Nakken, Ola; Lindstrøm, Jonas Christoffer; Tysnes, Ole-Bjørn; Holmøy, Trygve (Peer reviewed; Journal article, 2016-12)
      Recent studies suggest that the incidence and mortality of amyotrophic lateral sclerosis (ALS) are increasing. Changing environmental factors could influence disease risk differently throughout life span, and also between ...

    • Repeat expansions in AR, ATXN1, ATXN2 and HTT in Norwegian patients diagnosed with amyotrophic lateral sclerosis 

      Novy, Camilla; Busk, Øyvind; Tysnes, Ole-Bjørn; Landa, Sigve Strand; Aanjesen, Tori Navestad; Alstadhaug, Karl Bjørnar; Bjerknes, Tale Litlere; Bjørnå, Ingrid Kristine; Bråthen, Geir; Dahl, Elin; Demic, Natasha; Fahlström, Maria; Flemmen, Heidi Øyen; Hallerstig, Erika Carina; HogenEsch, Ineke; Kampman, Margitta; Kleveland, Grethe; Kvernmo, Helene Ballo; Ljøstad, Unn; Maniaol, Angelina; Morsund, Aase Hagen; Nakken, Ola; Olsen, Cathrine Goberg; Schlüter, Katrin Ruth; Utvik, May-Sissel; Yaseen, Ryaz; Holla, Øystein Lunde; Holmøy, Trygve; Høyer, Helle (Journal article; Peer reviewed, 2024)
      Genetic repeat expansions cause neuronal degeneration in amyotrophic lateral sclerosis as well as other neurodegenerative disorders such as spinocerebellar ataxia, Huntington’s disease and Kennedy’s disease. Repeat expansions ...

    • Strong tuberculin response after BCG vaccination is associated with low multiple sclerosis risk: a population-based cohort study 

      Nakken, Ola; Holmøy, Trygve; Stigum, Hein; Myhr, Kjell-Morten; Dahl, Jesper; Heldal, Einar; Meyer, Haakon Eduard (Journal article; Peer reviewed, 2022)
      Background: Multiple sclerosis (MS) is characterized by inflammatory lesions in the central nervous system involving pro-inflammatory T-cells. Immune dysregulation is well described in prevalent disease, but it is not known ...