Blar i Department of Clinical Medicine på tidsskrift "FEBS Letters"
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K+ regulates relocation of Pellino-2 to the site of NLRP3 inflammasome activation in macrophages
(Journal article; Peer reviewed, 2021)Pellino proteins are E3 ubiquitin ligases involved in the innate immune system. Recently, Pellino-2 was reported to modulate the activation of the mouse Nlrp3 inflammasome. We examined the intracellular localization of ... -
Pellino-2 in nonimmune cells: novel interaction partners and intracellular localization
(Journal article; Peer reviewed, 2021)Pellino-2 is an E3 ubiquitin ligase that mediates intracellular signaling in innate immune pathways. Most studies of endogenous Pellino-2 have been performed in macrophages, but none in nonimmune cells. Using yeast two-hybrid ... -
A Pellino-2 variant is associated with constitutive NLRP3 inflammasome activation in a family with ocular pterygium–digital keloid dysplasia
(Journal article; Peer reviewed, 2023)Ocular pterygium–digital keloid dysplasia (OPDKD) is a rare hereditary disease characterized by corneal ingrowth of vascularized conjunctival tissue early in life. Later, patients develop keloids on fingers and toes but ...