Browsing Department of Clinical Medicine by Journals "Frontiers in Cell and Developmental Biology"
Now showing items 1-4 of 4
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Distinct Mitochondrial Remodeling During Mesoderm Differentiation in a Human-Based Stem Cell Model
(Journal article; Peer reviewed, 2021-10-14)Given the considerable interest in using stem cells for modeling and treating disease, it is essential to understand what regulates self-renewal and differentiation. Remodeling of mitochondria and metabolism, with the shift ... -
Ferroptosis Holds Novel Promise in Treatment of Cancer Mediated by Non-coding RNAs
(Journal article; Peer reviewed, 2021)Ferroptosis is a newly identified form of regulated cell death that is associated with iron metabolism and oxidative stress. As a physiological mechanism, ferroptosis selectively removes cancer cells by regulating the ... -
Mitochondrial respiratory chain dysfunction—A hallmark pathology of idiopathic Parkinson’s disease?
(Journal article; Peer reviewed, 2022)Parkinson’s disease (PD) is the most common age-dependent neurodegenerative synucleinopathy. Loss of dopaminergic neurons of the substantia nigra pars compacta, together with region- and cell-specific aggregations of ... -
Nicotinamide Riboside and Metformin Ameliorate Mitophagy Defect in Induced Pluripotent Stem Cell-Derived Astrocytes With POLG Mutations
(Journal article; Peer reviewed, 2021)Mitophagy specifically recognizes and removes damaged or superfluous mitochondria to maintain mitochondrial homeostasis and proper neuronal function. Defective mitophagy and the resulting accumulation of damaged mitochondria ...