• Defective mitochondrial DNA homeostasis in the substantia nigra in Parkinson disease 

      Dölle, Christian; Flønes, Irene Hana; Sanchez Nido, Gonzalo; Miletic, Hrvoje; Osuagwu, Nelson; Kristoffersen, Stine; Lilleng, Peer Kåre; Larsen, Jan Petter; Tysnes, Ole-Bjørn; Haugarvoll, Kristoffer; Bindoff, Laurence; Tzoulis, Charalampos (Peer reviewed; Journal article, 2016-11-22)
      Increased somatic mitochondrial DNA (mtDNA) mutagenesis causes premature aging in mice, and mtDNA damage accumulates in the human brain with aging and neurodegenerative disorders such as Parkinson disease (PD). Here, we ...
    • An independent poor-prognosis subtype of breast cancer defined by a distinct tumor immune microenvironment 

      Tekpli, Xavier; Lien, Tonje Gulbrandsen; Røssevold, Andreas Hagen; Nebdal, Daniel J.H.; Borgen, Elin; Ohnstad, Hege Oma; Kyte, Jon A; Vallon-Christersson, Johan; Fongaard, Marie; Due, Eldri Undlien; Svartdal, Lisa Gregusson; Sveli, My Anh Tu; Garred, Øystein; Frigessi Di Rattalma, Arnoldo; Sahlberg, Kristine Kleivi; Sørlie, Therese; Russnes, Hege Elisabeth Giercksky; Naume, Bjørn; Kristensen, Vessela N. (Peer reviewed; Journal article, 2019)
      How mixtures of immune cells associate with cancer cell phenotype and affect pathogenesis is still unclear. In 15 breast cancer gene expression datasets, we invariably identify three clusters of patients with gradual levels ...