Blar i Department of Clinical Medicine på tidsskrift "Nature Communications"
Viser treff 1-4 av 4
-
Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores
(Journal article; Peer reviewed, 2021)Genetic discoveries of Alzheimer’s disease are the drivers of our understanding, and together with polygenetic risk stratification can contribute towards planning of feasible and efficient preventive and curative clinical ... -
Defective mitochondrial DNA homeostasis in the substantia nigra in Parkinson disease
(Peer reviewed; Journal article, 2016-11-22)Increased somatic mitochondrial DNA (mtDNA) mutagenesis causes premature aging in mice, and mtDNA damage accumulates in the human brain with aging and neurodegenerative disorders such as Parkinson disease (PD). Here, we ... -
An independent poor-prognosis subtype of breast cancer defined by a distinct tumor immune microenvironment
(Peer reviewed; Journal article, 2019)How mixtures of immune cells associate with cancer cell phenotype and affect pathogenesis is still unclear. In 15 breast cancer gene expression datasets, we invariably identify three clusters of patients with gradual levels ... -
Single-cell ATAC and RNA sequencing reveal pre-existing and persistent cells associated with prostate cancer relapse
(Journal article; Peer reviewed, 2021)Prostate cancer is heterogeneous and patients would benefit from methods that stratify those who are likely to respond to systemic therapy. Here, we employ single-cell assays for transposase-accessible chromatin (ATAC) and ...