Browsing Department of Clinical Medicine by Journals "The journal of pathology. Clinical research"
Now showing items 1-6 of 6
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CD47 and CD68 expression in breast cancer is associated with tumor-infiltrating lymphocytes, blood vessel invasion, detection mode, and prognosis
(Journal article; Peer reviewed, 2023)CD47 expressed on tumor cells binds to signal regulatory protein alpha on macrophages, initiating inhibition of phagocytosis. We investigated the relationships between tumor expression of CD47 and CD68 macrophage content, ... -
The epithelial–mesenchymal transition regulators Twist, Slug, and Snail are associated with aggressive tumour features and poor outcome in prostate cancer patients
(Journal article; Peer reviewed, 2021)The prognostic importance of transcription factors promoting epithelial–mesenchymal transition (EMT) and angiogenesis has not been well explored in prostate cancer patients with long follow-up, nor the interplay between ... -
FOXC2 expression and epithelial–mesenchymal phenotypes are associated with castration resistance, metastasis and survival in prostate cancer
(Peer reviewed; Journal article, 2019)Epithelial–mesenchymal transition (EMT) is important for tumour cell invasion and metastasis and is a feature of aggressive carcinomas. EMT is characterised by reduced E‐cadherin and increased N‐cadherin expression ... -
Integrin α11β1 is expressed in breast cancer stroma and associates with aggressive tumor phenotypes
(Peer reviewed; Journal article, 2020)Cancer‐associated fibroblasts are essential modifiers of the tumor microenvironment. The collagen‐binding integrin α11β1 has been proposed to be upregulated in a pro‐tumorigenic subtype of cancer‐associated fibroblasts. ... -
Microvascular proliferation is associated with aggressive tumour features and reduced survival in lung adenocarcinoma
(Peer reviewed; Journal article, 2017-10)Despite new treatment options in lung cancer, there is still a need for better biomarkers to assist in therapy decisions. Angiogenesis has been associated with tumour growth and dissemination, and the vascular proliferation ... -
Predictive value of angiogenic proteins in patients with metastatic melanoma treated with bevacizumab monotherapy
(Peer reviewed; Journal article, 2019)The incidence of malignant melanoma is rising worldwide and survival for metastatic disease is still poor. Recently, new treatment options have become available. Still, predictive biomarkers are needed to optimise treatment ...