Show simple item record

dc.contributor.authorWiren, Saraen_US
dc.contributor.authorHäggström, Christelen_US
dc.contributor.authorUlmer, Hannoen_US
dc.contributor.authorManjer, Jonasen_US
dc.contributor.authorBjørge, Toneen_US
dc.contributor.authorNagel, Gabrieleen_US
dc.contributor.authorJohansen, Dortheen_US
dc.contributor.authorHallmans, Göranen_US
dc.contributor.authorEngeland, Andersen_US
dc.contributor.authorConcin, Hansen_US
dc.contributor.authorJonsson, Håkanen_US
dc.contributor.authorSelmer, Randien_US
dc.contributor.authorTretli, Steinaren_US
dc.contributor.authorStocks, Tanjaen_US
dc.contributor.authorStattin, Pären_US
dc.description.abstractPurpose: To assess the association between height and risk of cancer and cancer death. Methods: The metabolic syndrome and cancer project is a prospective pooled cohort study of 585,928 participants from seven cohorts in Austria, Norway, and Sweden. Hazard ratios (HRs) and 95 % confidence intervals (CIs) for cancer incidence and death were estimated in height categories and per 5-cm increment for each cancer site using Cox proportional hazards model. Results: During a mean follow-up of 12.7 years (SD = 7.2), 38,862 participants were diagnosed with cancer and 13,547 participants died of cancer. Increased height (per 5-cm increment) was associated with an increased overall cancer risk in women, HR 1.07 (95 % CI 1.06–1.09), and in men, HR 1.04 (95 % CI 1.03–1.06). The highest HR was seen for malignant melanoma in women, HR 1.17 (95 % CI 1.11–1.24), and in men HR 1.12 (95 % CI 1.08–1.19). Height was also associated with increased risk of cancer death in women, HR 1.03 (95 % CI 1.01–1.16), and in men, HR 1.03 (95 % CI 1.01–1.05). The highest HR was observed for breast cancer death in postmenopausal women (>60 years), HR 1.10 (95 % CI 1.00–1.21), and death from renal cell carcinoma in men, HR 1.18 (95 % CI 1.07–1.30). All these associations were independent of body mass index. Conclusion: Height was associated with risk of cancer and cancer death indicating that factors related to height such as hormonal and genetic factors stimulate both cancer development and progression.en_US
dc.publisherSpringer International Publishingeng
dc.rightsAttribution CC BYeng
dc.subjectBody statureeng
dc.subjectBody heighteng
dc.subjectCancer riskeng
dc.subjectCohort studyeng
dc.titlePooled cohort study on height and risk of cancer and cancer deathen_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright The Author(s) 2013. This article is published with open access at
dc.source.journalCancer Causes and Control
dc.subject.nsiVDP::Medical sciences: 700::Clinical medical sciences: 750::Oncology: 762eng
dc.subject.nsiVDP::Medisinske fag: 700::Klinisk medisinske fag: 750::Onkologi: 762nob

Files in this item


This item appears in the following Collection(s)

Show simple item record

Attribution CC BY
Except where otherwise noted, this item's license is described as Attribution CC BY