dc.contributor.author | Karlsen, Tom Hemming | en_US |
dc.contributor.author | Boberg, Kirsten Muri | en_US |
dc.date.accessioned | 2015-04-09T09:17:22Z | |
dc.date.available | 2015-04-09T09:17:22Z | |
dc.date.issued | 2013-09 | eng |
dc.identifier.issn | 0168-8278 | |
dc.identifier.uri | https://hdl.handle.net/1956/9730 | |
dc.description.abstract | Primary sclerosing cholangitis (PSC) remains one of the most challenging conditions of clinical hepatology. There has been a steady growth in research to overcome this fact and the present review aims at summarizing the most recently published literature. The main emphasis will be put on the link of recent pathogenetic insights to clinical characteristics and patient management. With regard to pathogenesis, there is no consensus yet as to whether immune mediated injury or factors related to bile acid physiology are the most important. It also remains to be clarified whether PSC is a mixed bag of various secondary etiologies yet to be defined, or a disease entity predominantly represented by sclerosing cholangitis in the context of inflammatory bowel disease. Most important, there is no available medical therapy with proven influence on clinical end points, and timing of liver transplantation and patient follow-up are challenging due to the unpredictable and high risk of cholangiocarcinoma. | en_US |
dc.language.iso | eng | eng |
dc.publisher | Elsevier | eng |
dc.rights | Attribution-NonCommercial-NoDerivs CC BY-NC-ND | eng |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | eng |
dc.subject | Primary sclerosing cholangitis | eng |
dc.subject | Inflammatory bowel disease | eng |
dc.subject | Cholangiocarcinoma | eng |
dc.title | Update on primary sclerosing cholangitis | en_US |
dc.type | Peer reviewed | |
dc.type | Journal article | |
dc.date.updated | 2015-04-01T08:00:55Z | en_US |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | Copyright 2013 European Association for the Study of the Liver | |
dc.identifier.doi | https://doi.org/10.1016/j.jhep.2013.03.015 | |
dc.identifier.cristin | 1061101 | |
dc.source.journal | Journal of Hepatology | |
dc.source.40 | 59 | |
dc.source.14 | 3 | |
dc.source.pagenumber | 571-582 | |
dc.subject.nsi | VDP::Medical sciences: 700::Clinical medical sciences: 750::Gastroenterology: 773 | eng |
dc.subject.nsi | VDP::Medical sciences: 700::Clinical medical sciences: 750::Radiology and diagnostic imaging: 763 | eng |
dc.subject.nsi | VDP::Medisinske fag: 700::Klinisk medisinske fag: 750::Gasteroenterologi: 773 | nob |
dc.subject.nsi | VDP::Medisinske fag: 700::Klinisk medisinske fag: 750::Radiologi og bildediagnostikk: 763 | nob |