dc.contributor.author | Iles, Mark M. | en_US |
dc.contributor.author | Bishop, D. Timothy | en_US |
dc.contributor.author | Taylor, John C. | en_US |
dc.contributor.author | Hayward, Nicholas K. | en_US |
dc.contributor.author | Brossard, Myriam | en_US |
dc.contributor.author | Cust, Anne E. | en_US |
dc.contributor.author | Dunning, Alison M. | en_US |
dc.contributor.author | Lee, Jeffrey E. | en_US |
dc.contributor.author | Moses, Eric K. | en_US |
dc.contributor.author | Akslen, Lars A. | en_US |
dc.contributor.author | Andresen, Per Arne | en_US |
dc.contributor.author | Avril, Marie-Francoise | en_US |
dc.contributor.author | Azizi, Esther | en_US |
dc.contributor.author | Scarra, Giovanna Bianchi | en_US |
dc.contributor.author | Brown, Kevin M. | en_US |
dc.contributor.author | Debniak, Tadeusz | en_US |
dc.contributor.author | Elder, David E. | en_US |
dc.contributor.author | Friedman, Eitan | en_US |
dc.contributor.author | Ghiorzo, Paola | en_US |
dc.contributor.author | Gillanders, Elizabeth M. | en_US |
dc.contributor.author | Goldstein, Alisa M. | en_US |
dc.contributor.author | Gruis, Nelleke A. | en_US |
dc.contributor.author | Hansson, Johan | en_US |
dc.contributor.author | Harland, Mark | en_US |
dc.contributor.author | Helsing, Per | en_US |
dc.contributor.author | Hočevar, Marko | en_US |
dc.contributor.author | Höiom, Veronica | en_US |
dc.contributor.author | Ingvar, Christian | en_US |
dc.contributor.author | Kanetsky, Peter A. | en_US |
dc.contributor.author | Landi, Maria Teresa | en_US |
dc.contributor.author | Lang, Julie L. | en_US |
dc.contributor.author | Lathrop, G. Mark | en_US |
dc.contributor.author | Lubinski, Jan | en_US |
dc.contributor.author | Mackie, Rona M. | en_US |
dc.contributor.author | Martin, Nicholas G. | en_US |
dc.contributor.author | Molven, Anders | en_US |
dc.contributor.author | Montgomery, Grant W. | en_US |
dc.contributor.author | Novakovic, Srdian | en_US |
dc.contributor.author | Olsson, Håkan | en_US |
dc.contributor.author | Puig, Susana | en_US |
dc.contributor.author | Puig-Butille, Joan Anton | en_US |
dc.contributor.author | Radford-Smith, Graham L. | en_US |
dc.contributor.author | Randerson-Moor, Juliette | en_US |
dc.contributor.author | Study Group, SDH | en_US |
dc.contributor.author | van der Stoep, Nienke | en_US |
dc.contributor.author | van Doorn, Remco | en_US |
dc.contributor.author | Whiteman, David C. | en_US |
dc.contributor.author | MacGregor, Stuart | en_US |
dc.contributor.author | Pooley, Karen A. | en_US |
dc.contributor.author | Ward, Sarah V. | en_US |
dc.contributor.author | Mann, Graham J. | en_US |
dc.contributor.author | Amos, Christopher I. | en_US |
dc.contributor.author | Pharoah, Paul D.P. | en_US |
dc.contributor.author | Demenais, Florence | en_US |
dc.contributor.author | Law, Matthew H. | en_US |
dc.contributor.author | Bishop, Julia A. Newton | en_US |
dc.contributor.author | Barrett, Jennifer H. | en_US |
dc.date.accessioned | 2015-05-15T13:16:05Z | |
dc.date.available | 2015-05-15T13:16:05Z | |
dc.date.issued | 2014 | eng |
dc.identifier.issn | 0027-8874 | |
dc.identifier.uri | https://hdl.handle.net/1956/9890 | |
dc.description.abstract | Telomere length has been associated with risk of many cancers, but results are inconsistent. Seven single nucleotide polymorphisms (SNPs) previously associated with mean leukocyte telomere length were either genotyped or well-imputed in 11108 case patients and 13933 control patients from Europe, Israel, the United States and Australia, four of the seven SNPs reached a P value under .05 (two-sided). A genetic score that predicts telomere length, derived from these seven SNPs, is strongly associated (P = 8.92x10-9, two-sided) with melanoma risk. This demonstrates that the previously observed association between longer telomere length and increased melanoma risk is not attributable to confounding via shared environmental effects (such as ultraviolet exposure) or reverse causality. We provide the first proof that multiple germline genetic determinants of telomere length influence cancer risk. | en_US |
dc.language.iso | eng | eng |
dc.publisher | Oxford University Press | eng |
dc.rights | Attribution CC BY | eng |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/ | eng |
dc.title | The effect on melanoma risk of genes previously associated with telomere length | en_US |
dc.type | Peer reviewed | |
dc.type | Journal article | |
dc.date.updated | 2015-04-08T11:14:41Z | en_US |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | Copyright 2014 The Authors | |
dc.source.articlenumber | dju267 | |
dc.identifier.doi | https://doi.org/10.1093/jnci/dju267 | |
dc.identifier.cristin | 1158542 | |
dc.source.journal | Journal of the National Cancer Institute | |
dc.source.40 | 106 | |
dc.source.14 | 10 | |
dc.relation.project | Norges forskningsråd: 191778 | |
dc.relation.project | Norges forskningsråd: 223250 | |
dc.subject.nsi | VDP::Medical sciences: 700::Basic medical, dental and veterinary sciences: 710::General pathology, anatomical pathology: 719 | eng |
dc.subject.nsi | VDP::Medical sciences: 700::Basic medical, dental and veterinary sciences: 710::Medical genetics: 714 | eng |
dc.subject.nsi | VDP::Medisinske fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Generell patologi, patologisk anatomi : 719 | nob |
dc.subject.nsi | VDP::Medisinske fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Medisinsk genetikk: 714 | nob |