Browsing University of Bergen Library by Title

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    • Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits 

      Vogelezang, Suzanne; Bradfield, Jonathan P.; Ahluwalia, Tarunveer S.; Curtin, John A.; Lakka, Timo A.; Grarup, Niels; Scholz, Markus; van der Most, Peter J.; Monnereau, Claire; Stergiakouli, Evie; Heiskala, Anni; Horikoshi, Momoko; Fedko, Iryna O.; Vilor-Tejedor, Natalia; Cousminer, Diana L.; Standl, Marie; Wang, Carol A.; Viikari, Jorma; Geller, Frank; Íñiguez, Carmen; Pitkänen, Niina; Chesi, Alessandra; Bacelis, Jonas; Yengo, Loic; Torrent, Maties; Ntalla, Ioanna; Helgeland, Øyvind; Selzam, Saskia; Vonk, Judith M.; Zafarmand, Mohammed H.; Heude, Barbara; Farooqi, Ismaa Sadaf; Alyass, Akram; Beaumont, Robin N.; Have, Christian T.; Rzehak, Peter; Bilbao, Jose Ramon; Schnurr, Theresia M.; Barroso, Inês; Bønnelykke, Klaus; Beilin, Lawrence J.; Carstensen, Lisbeth; Charles, Marie-Aline; Chawes, Bo; Clément, Karine; Closa-Monasterolo, Ricardo; Custovic, Adnan; Eriksson, Johan G.; Vaudel, Marc; Njølstad, Pål Rasmus (Journal article; Peer reviewed, 2020)
      The genetic background of childhood body mass index (BMI), and the extent to which the well-known associations of childhood BMI with adult diseases are explained by shared genetic factors, are largely unknown. We performed ...

    • The novel microRNAs hsa-miR-nov7 and hsamiR- nov3 are over-expressed in locally advanced breast cancer 

      Poduval, Deepak; Sichmanovà, Zuzana; Straume, Anne Hege; Lønning, Per Eystein; Knappskog, Stian (Journal article; Peer reviewed, 2020)
      miRNAs are an important class of small non-coding RNAs, which play a versatile role in gene regulation at the post-transcriptional level. Expression of miRNAs is often deregulated in human cancers. We analyzed small RNA ...

    • A novel moderately thermophilic facultative methylotroph within the class Alphaproteobacteria 

      Islam, Tajul; Hernández, Marcela; Gessesse, Amare; Colin Murrell, Murrell; Øvreås, Lise (Journal article; Peer reviewed, 2021-02-25)
      Methylotrophic bacteria (non-methanotrophic methanol oxidizers) consuming reduced carbon compounds containing no carbon–carbon bonds as their sole carbon and energy source have been found in a great variety of environments. ...

    • A Novel Moderately Thermophilic Type Ib Methanotroph Isolated from an Alkaline Thermal Spring in the Ethiopian Rift Valley 

      Islam, Tajul; Gessesse, Amare; Garcia-Moyano, Antonio; Murrell, J. Colin; Øvreås, Lise (Journal article; Peer reviewed, 2020-02-13)
      Aerobic moderately thermophilic and thermophilic methane-oxidizing bacteria make a substantial contribution in the control of global warming through biological reduction of methane emissions and have a unique capability ...

    • A novel MRI index for paraspinal muscle fatty infiltration: reliability and relation to pain and disability in lumbar spinal stenosis: results from a multicentre study 

      Aaen, Jørn Ståle; Storheim, Kjersti; Negård, Anne; Myklebust, Tor Åge; Grotle, Margreth; Hellum, Christian; Espeland, Ansgar; Anvar, Masoud D; Indrekvam, Kari; Weber, Clemens; Brox, Jens Ivar; Brisby, Helena; Hermansen, Erland; Banitalebi, Hasan (Journal article; Peer reviewed, 2022)
      Background Fatty infiltration of the paraspinal muscles may play a role in pain and disability in lumbar spinal stenosis. We assessed the reliability and association with clinical symptoms of a method for assessing fatty ...

    • Novel neonatal simulator provides high-fidelity ventilation training comparable to real-life newborn ventilation 

      Haynes, Joanna; Bjorland, Peder Aleksander; Gomo, Øystein; Ushakova, Anastasia; Rettedal, Siren; Perlman, Jeffrey M.; Ersdal, Hege Langli (Journal article; Peer reviewed, 2021)
      Face mask ventilation of apnoeic neonates is an essential skill. However, many non-paediatric healthcare personnel (HCP) in high-resource childbirth facilities receive little hands-on real-life practice. Simulation training ...

    • Novel oxygen desaturation parameters are associated with cardiac troponin I: Data from the Akershus Sleep Apnea Project 

      Sigurdardóttir, Fjóla Dögg; Øverby, Tonje Caroline; Nikkonen, Sami; Karhu, Tuomas; Dammen, Toril; Nordhus, Inger Hilde; Thorshov, Thea Christine; Einvik, Gunnar; Kainulainen, Samu; Leppänen, Timo; Arnardottir, Erna Sif; Töyräs, Juha; Omland, Torbjørn; Hrubos-Strøm, Harald (Journal article; Peer reviewed, 2022)
      Novel diagnostic markers for obstructive sleep apnea beyond the apnea–hypopnea index (AHI) have been introduced. There are no studies on their association with markers of subclinical myocardial injury. We assessed the ...

    • A novel patient-reported outcome monitoring with clinical feedback system in bariatric surgery care: study protocol, design and plan for evaluation 

      Hegland, Pål Andre; Aasprang, Anny; Kolotkin, Ronette Loganzo; Moltu, Christian; Tell, Grethe S.; Andersen, John Roger (Journal article; Peer reviewed, 2020)
      Background: Consultations before and after bariatric surgery should include structured assessments of patients’ health-related quality of life (HRQOL) and mental health. One way to conduct this assessment is to implement ...

    • A Novel Prophylaxis Strategy Using Liposomal Vaccine Adjuvant CAF09b Protects against Influenza Virus Disease 

      Zimmermann, Julie; Schmidt, Signe Tandrup; Trebbien, Ramona; Cox, Rebecca Jane; Zhou, Fan; Follmann, Frank; Pedersen, Gabriel Kristian; Christensen, Dennis (Journal article; Peer reviewed, 2022-02-06)
      The SARS-CoV-2 pandemic caused a massive health and societal crisis, although the fast development of effective vaccines reduced some of the impact. To prepare for future respiratory virus pandemics, a pan-viral prophylaxis ...

    • A novel protist parasite, Salmoxcellia vastator n. gen., n. sp. (Xcelliidae, Perkinsozoa), infecting farmed salmonids in Norway 

      Karlsbakk, Egil Erlingsson; Nystøyl, Cecilie Flatnes; Plarre, Heidrun; Nylund, Are (Journal article; Peer reviewed, 2021)
      Background In Norway, x-cell parasites associated with disease in farmed salmonids have been known as a rare phenomenon for two decades. These parasites cause systemic infections in farmed rainbow trout (Oncorhynchus ...

    • Novel RAB27A Variant Associated with Late-Onset Hemophagocytic Lymphohistiocytosis Alters Effector Protein Binding 

      Zondag, Timo C. E.; Torralba-Raga, Lamberto; Van Laar, Jan A. M.; Hermans, Maud A. W.; Bouman, Arjen; Hollink, Iris H. I. M.; Van Hagen, P. Martin; Briggs, Deborah A.; Hume, Alistair N.; Bryceson, Yenan (Journal article; Peer reviewed, 2022)
      Autosomal recessive mutations in RAB27A are associated with Griscelli syndrome type 2 (GS2), characterized by hypopigmentation and development of early-onset, potentially fatal hemophagocytic lymphohistiocytosis (HLH). We ...

    • Novel Reclassification of Adult Diabetes Is Useful to Distinguish Stages of β-Cell Function Linked to the Risk of Vascular Complications: The DOLCE Study From Northern Ukraine 

      Fedotkina, Olena; Sulaieva, Oksana; Özgümüs, Türküler; Cherviakova, Liubov; Khalimon, Nadiya; Svietleisha, Tetiana; Buldenko, Tetiana; Ahlqvist, Emma; Asplund, Olof; Groop, Leif; Nilsson, Peter M.; Lyssenko, Valeriya (Journal article; Peer reviewed, 2021)
      Background: Presently, persons with diabetes are classified as having type 1 (T1D) or type 2 diabetes (T2D) based on clinical diagnosis. However, adult patients exhibit diverse clinical representations and this makes ...

    • The novel reconsidered: Emotions and anti-realism in mid-19th-century Scandinavian literature 

      Bohlin, Anna (Journal article; Peer reviewed, 2021)
      The aim of the present article is to investigate the novel as remediation of nationalist pedagogy: how was the pedagogical, nationalist project charged with emotions? How did elements from non-realist genres make emotions ...

    • A novel splice-affecting HNF1A variant with large population impact on diabetes in Greenland 

      Thuesen, Anne Cathrine; Stæger, Fredrik Filip; Kaci, Alba; Solheim, Marie Holm; Aukrust, Ingvild; Jørsboe, Emil; Santander, Cindy G.; Andersen, Mette; Li, Zilong; Gilly, Arthur; Stinson, Sara Elizabeth; Gjesing, Anette Prior; Bjerregaard, Peter; Pedersen, Michael Lynge; Larsen, Christina Viskum Lytken; Grarup, Niels; Jørgensen, Marit E.; Zeggini, Eleftheria; Bjørkhaug, Lise; Njølstad, Pål Rasmus; Albrechtsen, Anders; Moltke, Ida; Hansen, Torben (Journal article; Peer reviewed, 2023)
      Background: The genetic disease architecture of Inuit includes a large number of common high-impact variants. Identification of such variants contributes to our understanding of the genetic aetiology of diseases and improves ...

    • Novel STAT3 Inhibitors Targeting STAT3 Dimerization by Binding to the STAT3 SH2 Domain 

      Hua, Yaping; Yuan, Xing; Shen, Yun-Heng; Wang, Jinxin; Azeem, Waqas; Yang, Shuo; Gade, Alexandra; Lellahi, Seyed Mohammad; Øyan, Anne Margrete; Ke, Xisong; Zhang, Wei-Dong; Kalland, Karl Henning (Journal article; Peer reviewed, 2022)
      Our drug discovery model has identified two novel STAT3 SH2 domain inhibitors 323–1 and 323–2 (delavatine A stereoisomers) in a series of experiments. In silico computational modeling, drug affinity responsive target ...

    • Nowcasting COVID-19 incidence indicators during the Italian first outbreak 

      Alaimo Di Loro, Pierfrancesco; Divino, Fabio; Farcomeni, Alessio; Jona Lasinio, Giovanna; Lovison, Gianfranco; Maruotti, Antonello; Mingione, Marco (Journal article; Peer reviewed, 2021)
      A novel parametric regression model is proposed to fit incidence data typically collected during epidemics. The proposal is motivated by real-time monitoring and short-term forecasting of the main epidemiological indicators ...

    • NPM1-Mutated Patient-Derived AML Cells Are More Vulnerable to Rac1 Inhibition 

      Hemsing, Anette Lodvir; Rye, Kristin Paulsen; Hatfield, Kimberley Joanne; Reikvam, Håkon (Journal article; Peer reviewed, 2022)
      The prognosis of acute myeloid leukemia (AML) is poor, especially for the elderly population. Targeted therapy with small molecules may be a potential strategy to overcome chemoresistance and improve survival in AML. We ...

    • NSAID use is not associated with Parkinson's disease incidence: A Norwegian Prescription Database study 

      Brakedal, Brage; Tzoulis, Charalampos; Tysnes, Ole-Bjørn; Haugarvoll, Kristoffer (Journal article; Peer reviewed, 2021-09-07)
      Objective: Whether use of nonsteroidal anti-inflammatory drugs (NSAIDs) reduce the risk of incident Parkinson’s disease (PD) remains unresolved. Here, we employed the Norwegian Prescription Database to examine whether NSAID ...

    • Nuclear and Mitochondrial Circulating Cell-Free DNA Is Increased in Patients With Inflammatory Bowel Disease in Clinical Remission 

      Vrablicova, Zuzana; Tomova, Kristina; Tothova, Lubomira; Babickova, Janka; Gromova, Barbora; Konecna, Barbora; Liptak, Robert; Hlavaty, Tibor; Gardlik, Roman (Journal article; Peer reviewed, 2020)
      Background: The role of cell-free DNA (cfDNA) in the pathogenesis of inflammatory bowel disease (IBD) has been recently suggested. The aim of this study was to analyze circulating cfDNA and deoxyribonuclease (DNase) activity ...

    • Nuclear modification factor of light neutral-meson spectra up to high transverse momentum in p–Pb collisions at √sNN = 8.16 TeV 

      Acharya, Shreyasi; Adamová, Dagmar; Adler, Alexander; Adolfsson, Jonatan; Aglieri Rinella, Gianluca; Agnello, Michelangelo; Agrawal, Nikita; Ahammed, Zubayer; Ahmad, Shafiq F.; Ahn, Sang Un; Alme, Johan; Altenkaemper, Lucas; Djuvsland, Øystein; Eikeland, Viljar Nilsen; Ersdal, Magnus Rentsch; Fionda, Fiorella Maria Celeste; Grøttvik, Ola Slettevoll; Lofnes, Ingrid Mckibben; Nystrand, Joakim Ingemar; Rehman, Attiq Ur; Röhrich, Dieter; Sætre, Jon-Are; Tambave, Ganesh Jagannath; Ullaland, Kjetil; Wagner, Boris; Yang, Shiming; Yuan, Shiming; Arsene, Ionut Cristian; Dordic, Olja; Malik, Qasim Waheed; Neagu, Alexandra; Richter, Matthias; Røed, Ketil; Skaali, Toralf Bernhard; Storehaug, Ida Torkjellsdatter; Tveter, Trine Spedstad; Wikne, Jon Christopher; Helstrup, Håvard; Hetland, Kristin Fanebust; Kileng, Bjarte; Nesbø, Simon Voigt; Reme-Ness, Haakon André; Storetvedt, Maksim Melnik; Langøy, Rune; Lien, Jørgen André; Ahuja, Ishaan; Akbar, Zaenai; Akindinov, Alexander; Al-Turany, Mohammed; Alam, Sk Noor; ALICE, Collaboration (Journal article; Peer reviewed, 2022)
      Neutral pion (π0) and η meson production cross sections were measured up to unprecedentedly high transverse momenta (pT) in p–Pb collisions at √sNN = 8.16 TeV. The mesons were reconstructed via their two-photon decay channel ...