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dc.contributor.authorWjst, Matthiaseng
dc.contributor.authorDharmage, Shyamalieng
dc.contributor.authorAndré, Elisabetheng
dc.contributor.authorNorbäck, Daneng
dc.contributor.authorRaherison, Chantaleng
dc.contributor.authorVillani, Simonaeng
dc.contributor.authorManfreda, Jureeng
dc.contributor.authorSunyer, Jordieng
dc.contributor.authorJarvis, Deboraheng
dc.contributor.authorBurney, Petereng
dc.contributor.authorSvanes, Cecilieeng
dc.date.accessioned2006-11-30T10:06:24Z
dc.date.available2006-11-30T10:06:24Z
dc.date.issued2005-10-04eng
dc.identifier.issn1549-1277eng
dc.identifier.urihttp://hdl.handle.net/1956/1994
dc.description.abstractBackground: The space and time distribution of risk factors for allergic diseases may provide insights into disease mechanisms. Allergy is believed to vary by month of birth, but multinational studies taking into account latitude have not been conducted. Methods and Findings: A questionnaire was distributed in 54 centres to a representative sample of 20- to 44-y-old men and women mainly in Europe but also including regions in North Africa, India, North America, Australia, and New Zealand. Data from 200,682 participants were analyzed. The median prevalence of allergic rhinitis was 22%, with a substantial variation across centres. Overall, allergic rhinitis decreased with geographical latitude, but there were many exceptions. No increase in prevalence during certain winters could be observed. Also, no altered risk by birth month was found, except borderline reduced risks in September and October. Effect estimates obtained by a multivariate analysis of total and specific IgE values in 18,085 individuals also excluded major birth month effects and confirmed the independent effect of language grouping. Conclusion: Neither time point of first exposure to certain allergens nor early infections during winter months seems to be a major factor for adult allergy. Although there might be effects of climate or environmental UV exposure by latitude, influences within language groups seem to be more important, reflecting so far unknown genetic or cultural risk factors.en
dc.format.extent238140 byteseng
dc.format.mimetypeapplication/pdfeng
dc.language.isoengeng
dc.publisherPublic Library of Scienceeng
dc.relation.ispartofseriesPLoS Medicine 2(10): e294en
dc.titleLatitude, Birth Date, and Allergyeng
dc.typeJournal articleeng
dc.typePeer reviewedeng
dc.subject.nsiVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750nob
bora.peerreviewedPeer reviewedeng
bora.cristinID394378eng
bibo.doihttp://dx.doi.org/10.1371/journal.pmed.0020294eng
dc.identifier.cristinID394378eng
dc.identifier.doihttp://dx.doi.org/10.1371/journal.pmed.0020294


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