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Latitude, Birth Date, and Allergy

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dc.contributor.author Wjst, Matthias
dc.contributor.author Dharmage, Shyamali
dc.contributor.author André, Elisabeth
dc.contributor.author Norbäck, Dan
dc.contributor.author Raherison, Chantal
dc.contributor.author Villani, Simona
dc.contributor.author Manfreda, Jure
dc.contributor.author Sunyer, Jordi
dc.contributor.author Jarvis, Deborah
dc.contributor.author Burney, Peter
dc.contributor.author Svanes, Cecilie
dc.date.accessioned 2006-11-30T10:06:24Z
dc.date.available 2006-11-30T10:06:24Z
dc.date.issued 2005-10-04
dc.identifier.issn 1549-1277
dc.identifier.uri http://dx.doi.org/10.1371/journal.pmed.0020294
dc.identifier.uri http://hdl.handle.net/1956/1994
dc.description.abstract Background: The space and time distribution of risk factors for allergic diseases may provide insights into disease mechanisms. Allergy is believed to vary by month of birth, but multinational studies taking into account latitude have not been conducted. Methods and Findings: A questionnaire was distributed in 54 centres to a representative sample of 20- to 44-y-old men and women mainly in Europe but also including regions in North Africa, India, North America, Australia, and New Zealand. Data from 200,682 participants were analyzed. The median prevalence of allergic rhinitis was 22%, with a substantial variation across centres. Overall, allergic rhinitis decreased with geographical latitude, but there were many exceptions. No increase in prevalence during certain winters could be observed. Also, no altered risk by birth month was found, except borderline reduced risks in September and October. Effect estimates obtained by a multivariate analysis of total and specific IgE values in 18,085 individuals also excluded major birth month effects and confirmed the independent effect of language grouping. Conclusion: Neither time point of first exposure to certain allergens nor early infections during winter months seems to be a major factor for adult allergy. Although there might be effects of climate or environmental UV exposure by latitude, influences within language groups seem to be more important, reflecting so far unknown genetic or cultural risk factors. en
dc.format.extent 238140 bytes
dc.format.mimetype application/pdf
dc.language.iso eng en
dc.publisher Public Library of Science en
dc.relation.ispartofseries PLoS Medicine 2(10): e294 en
dc.title Latitude, Birth Date, and Allergy en
dc.type Journal article en
dc.type Peer reviewed en
dc.subject.nsi VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750 en
bora.cristinID 394378


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