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Afferent arteriolopathy and glomerular collapse but not segmental sclerosis induce tubular atrophy in old spontaneously hypertensive rats

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dc.contributor.author Leh, Sabine eng
dc.contributor.author Hultström, Michael eng
dc.contributor.author Rosenberger, Christian eng
dc.contributor.author Iversen, Bjarne M. eng
dc.date.accessioned 2011-11-21T12:31:35Z
dc.date.available 2011-11-21T12:31:35Z
dc.date.issued 2011-06-10 eng
dc.identifier.citation Virchows Archiv 459(1): 99-108 en
dc.identifier.issn 0945-6317 eng
dc.identifier.uri http://hdl.handle.net/1956/5208
dc.description.abstract In chronic renal disease, the temporal and spatial relationship between vascular, glomerular and tubular changes is still unclear. Hypertension, an important cause of chronic renal failure, leads to afferent arteriolopathy, segmental glomerulosclerosis and tubular atrophy in the juxtamedullary cortex. We investigated the pathological changes of hypertensive renal disease in aged spontaneously hypertensive rats using a large number of serial sections, where we traced and analyzed afferent arteriole, glomerulus and proximal tubule of single nephrons. Our major finding was that both afferent arteriolopathy and glomerular capillary collapse were linked to tubular atrophy. Only nephrons with glomerular collapse (n=13) showed tubules with reduced diameter indicating atrophy [21.66±2.56 μm vs. tubules in normotensive Wistar Kyoto rats (WKY) 38.56±0.56 μm, p<0.05], as well as afferent arteriolar wall hypertrophy (diameter 32.74±4.72 μm vs. afferent arterioles in WKY 19.24±0.98 μm, p<0.05). Nephrons with segmental sclerosis (n=10) did not show tubular atrophy and tubular diameters were unchanged (35.60±1.43 μm). Afferent arteriolar diameter negatively correlated with glomerular capillary volume fraction (r=−0.36) and proximal tubular diameter (r=−0.46) implying reduced glomerular and tubular flow. In line with this, chronically damaged tubules showed reduced staining for the ciliary protein inversin indicating changed ciliary signalling due to reduced urinary flow. This is the first morphological study on hypertensive renal disease making correlations between vascular, glomerular and tubular components of individual nephron units. Our data suggest that afferent arteriolopathy leads to glomerular collapse and reduced urinary flow with subsequent tubular atrophy. en
dc.language.iso eng eng
dc.publisher Springer eng
dc.relation.ispartof <a href="http://hdl.handle.net/1956/5961" target="blank">Progression of renal disease. Pathogenetic aspects and treatment options</a> en
dc.rights.uri http://www.springer.com/open+access/open+choice?SGWID=0-40359-0-0-0 eng
dc.subject Glomerular collapse eng
dc.subject Tubular atrophy eng
dc.title Afferent arteriolopathy and glomerular collapse but not segmental sclerosis induce tubular atrophy in old spontaneously hypertensive rats eng
dc.type Peer reviewed eng
dc.type Journal article eng
dc.subject.nsi VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Nephrology, urology: 772 eng
dc.rights.holder ©The Author(s) 2011
dc.type.version publishedVersion eng
bora.peerreviewed Peer reviewed eng
bibo.doi http://dx.doi.org/10.1007/s00428-011-1100-3 eng
dc.identifier.doi http://dx.doi.org/10.1007/s00428-011-1100-3


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