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Acute effects of orexigenic antipsychotic drugs on lipid and carbohydrate metabolism in rat

Bergen Open Research Archive

Show simple item record Jassim, Goran Skrede, Silje Vázquez, María Jesús Wergedahl, Hege Vik-Mo, Audun O. Lunder, Niclas Diéguez, Carlos Vidal-Puig, Antonio Berge, Rolf K. López, Miguel Steen, Vidar Martin Fernø, Johan 2012-01-18T09:38:30Z 2012-01-18T09:38:30Z 2011-07-12
dc.identifier.citation Psychopharmacology 219(3): 783-794 en
dc.identifier.issn 0033-3158
dc.description.abstract This study aims to investigate whether orexigenic antipsychotic drugs may induce dyslipidemia and glucose disturbances in female rats through direct perturbation of metabolically active peripheral tissues, independent of prior weight gain. Methods In the current study, we examined whether a single intraperitoneal injection of clozapine or olanzapine induced metabolic disturbances in adult female outbred Sprague–Dawley rats. Serum glucose and lipid parameters were measured during time-course experiments up to 48 h. Real-time quantitative PCR was used to measure specific transcriptional alterations in lipid and carbohydrate metabolism in adipose tissue depots or in the liver. Results Our results demonstrated that acute administration of clozapine or olanzapine induced a rapid, robust elevation of free fatty acids and glucose in serum, followed by hepatic accumulation of lipids evident after 12–24 h. These metabolic disturbances were associated with biphasic patterns of gluconeogenic and lipid-related gene expression in the liver and in white adipose tissue depots. Conclusion Our results support that clozapine and olanzapine are associated with primary effects on carbohydrate and lipid metabolism associated with transcriptional changes in metabolically active peripheral tissues prior to the development of drug-induced weight gain. en
dc.language.iso eng en
dc.publisher Springer en
dc.rights ©The Author(s) 2011 en
dc.rights.uri en
dc.subject Antipsychotics en
dc.subject Clozapine en
dc.subject Diabetes en
dc.subject Obesity en
dc.title Acute effects of orexigenic antipsychotic drugs on lipid and carbohydrate metabolism in rat en
dc.type Peer reviewed en
dc.type Journal article en
dc.subject.nsi VDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710::Pharmacology: 728 en
dc.type.version publishedVersion en

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