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dc.contributor.authorJassim, Goraneng
dc.contributor.authorSkrede, Siljeeng
dc.contributor.authorVázquez, María Jesúseng
dc.contributor.authorWergedahl, Hegeeng
dc.contributor.authorVik-Mo, Audun O.eng
dc.contributor.authorLunder, Niclaseng
dc.contributor.authorDiéguez, Carloseng
dc.contributor.authorVidal-Puig, Antonioeng
dc.contributor.authorBerge, Rolf K.eng
dc.contributor.authorLópez, Migueleng
dc.contributor.authorSteen, Vidar Martineng
dc.contributor.authorFernø, Johaneng
dc.date.accessioned2012-01-18T09:38:30Z
dc.date.available2012-01-18T09:38:30Z
dc.date.issued2011-07-12eng
dc.identifier.citationPsychopharmacology 219(3): 783-794en
dc.identifier.issn0033-3158eng
dc.identifier.urihttp://hdl.handle.net/1956/5447
dc.description.abstractThis study aims to investigate whether orexigenic antipsychotic drugs may induce dyslipidemia and glucose disturbances in female rats through direct perturbation of metabolically active peripheral tissues, independent of prior weight gain. Methods In the current study, we examined whether a single intraperitoneal injection of clozapine or olanzapine induced metabolic disturbances in adult female outbred Sprague–Dawley rats. Serum glucose and lipid parameters were measured during time-course experiments up to 48 h. Real-time quantitative PCR was used to measure specific transcriptional alterations in lipid and carbohydrate metabolism in adipose tissue depots or in the liver. Results Our results demonstrated that acute administration of clozapine or olanzapine induced a rapid, robust elevation of free fatty acids and glucose in serum, followed by hepatic accumulation of lipids evident after 12–24 h. These metabolic disturbances were associated with biphasic patterns of gluconeogenic and lipid-related gene expression in the liver and in white adipose tissue depots. Conclusion Our results support that clozapine and olanzapine are associated with primary effects on carbohydrate and lipid metabolism associated with transcriptional changes in metabolically active peripheral tissues prior to the development of drug-induced weight gain.en
dc.language.isoengeng
dc.publisherSpringereng
dc.rights.urihttp://www.springer.com/open+access/open+choice?SGWID=0-40359-0-0-0eng
dc.subjectAntipsychoticseng
dc.subjectClozapineeng
dc.subjectDiabeteseng
dc.subjectObesityeng
dc.titleAcute effects of orexigenic antipsychotic drugs on lipid and carbohydrate metabolism in rateng
dc.typePeer reviewedeng
dc.typeJournal articleeng
dc.subject.nsiVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710::Pharmacology: 728eng
dc.rights.holder©The Author(s) 2011
dc.type.versionpublishedVersioneng
bora.peerreviewedPeer reviewedeng
bibo.doihttp://dx.doi.org/10.1007/s00213-011-2397-yeng
dc.identifier.doihttp://dx.doi.org/10.1007/s00213-011-2397-y


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