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Physical Activity Attenuates the Influence of FTO Variants on Obesity Risk: A Meta-Analysis of 218,166 Adults and 19,268 Children

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dc.contributor.author Kilpeläinen, Tuomas O. eng
dc.contributor.author Qi, Lu eng
dc.contributor.author Brage, Soren eng
dc.contributor.author Sharp, Stephen J. eng
dc.contributor.author Sonestedt, Emily eng
dc.contributor.author Demerath, Ellen eng
dc.contributor.author Johansson, Stefan eng
dc.contributor.author Njølstad, Pål Rasmus eng
dc.date.accessioned 2012-02-29T09:41:41Z
dc.date.available 2012-02-29T09:41:41Z
dc.date.issued 2011-11-01 eng
dc.identifier.citation PLoS Med 8(11): e1001116 en
dc.identifier.issn 1549-1277 eng
dc.identifier.uri http://hdl.handle.net/1956/5660
dc.description There are 116 authors. Only a few of them have been given author entries. en
dc.description.abstract Background: The FTO gene harbors the strongest known susceptibility locus for obesity. While many individual studies have suggested that physical activity (PA) may attenuate the effect of FTO on obesity risk, other studies have not been able to confirm this interaction. To confirm or refute unambiguously whether PA attenuates the association of FTO with obesity risk, we meta-analyzed data from 45 studies of adults (n=218,166) and nine studies of children and adolescents (n=19,268). Methods and Findings: All studies identified to have data on the FTO rs9939609 variant (or any proxy [r2.0.8]) and PA were invited to participate, regardless of ethnicity or age of the participants. PA was standardized by categorizing it into a dichotomous variable (physically inactive versus active) in each study. Overall, 25% of adults and 13% of children were categorized as inactive. Interaction analyses were performed within each study by including the FTO6PA interaction term in an additive model, adjusting for age and sex. Subsequently, random effects meta-analysis was used to pool the interaction terms. In adults, the minor (A2) allele of rs9939609 increased the odds of obesity by 1.23-fold/allele (95% CI 1.20–1.26), but PA attenuated this effect (pinteraction = 0.001). More specifically, the minor allele of rs9939609 increased the odds of obesity less in the physically active group (odds ratio = 1.22/allele, 95% CI 1.19–1.25) than in the inactive group (odds ratio = 1.30/ allele, 95% CI 1.24–1.36). No such interaction was found in children and adolescents. Conclusions: The association of the FTO risk allele with the odds of obesity is attenuated by 27% in physically active adults, highlighting the importance of PA in particular in those genetically predisposed to obesity. en
dc.language.iso eng eng
dc.publisher Public Library of Science eng
dc.rights Attribution CC BY eng
dc.rights.uri http://creativecommons.org/licenses/by/2.5/ eng
dc.title Physical Activity Attenuates the Influence of FTO Variants on Obesity Risk: A Meta-Analysis of 218,166 Adults and 19,268 Children eng
dc.type Peer reviewed eng
dc.type Journal article eng
dc.subject.nsi VDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710::Medical genetics: 714 eng
dc.rights.holder Copyright 2011 Loos et al.
dc.type.version publishedVersion eng
bora.peerreviewed Peer reviewed eng
bibo.doi http://dx.doi.org/10.1371/journal.pmed.1001116 eng
dc.identifier.doi http://dx.doi.org/10.1371/journal.pmed.1001116


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