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dc.contributor.authorEikeland, Randieng
dc.contributor.authorMygland, Åseeng
dc.contributor.authorHerlofson, Kareneng
dc.contributor.authorLjøstad, Unneng
dc.date.accessioned2012-07-02T11:15:22Z
dc.date.available2012-07-02T11:15:22Z
dc.date.issued2011eng
dc.identifier.citationActa Neurologica Scandinavicaen
dc.identifier.issn0001-6314eng
dc.identifier.urihttp://hdl.handle.net/1956/5869
dc.description.abstractAim: To identify risk factors for a non-favourable long term outcome with respect to Health Related Quality of Life (HRQoL) and fatigue after treated Lyme Neuroborreliosis (LNB). Methods: We followed 50 LNB patients, and assessed outcome by the self-report questionnaires Short Form-36 (SF-36) and Fatigue Severity Scale (FSS) 30 months after treatment. We analyzed associations between these outcomes and demographical, clinical and laboratory data by univariate analyses and linear regression. Clinical status was assessed by a composite score based on subjective complaints and objective findings. Results: Pre-treatment symptom duration > 6 weeks (B=-10.2, P=0.002) and non-complete recovery at 12 months (B=-5.6, P=0.033) were associated with lower scores in the SF-36 domain Physical Component Summary (R2=0.59). Non-complete recovery at 4 months was associated with lower scores in the SF-36 domain Mental Component Summary (B=-8.9, P=0.01 (R2= 0.37)). Pre-treatment symptom duration > 6 weeks (B=1.3, P= 0.028), high scores on the composite clinical score pre-treatment (B=0.1, P=0.019) and non-complete recovery at 12 months (B=1.7, P=0.001) were associated with higher FSS scores (R2=0.70). No laboratory test results were associated with these outcomes. Conclusions: Delayed treatment start, more symptoms and findings before and non-complete recovery at 4 and 12 months after treatment seem to predict a non-favourable outcome regarding HRQoL and fatigue 30 months after treated LNB. Age, gender, educational level involvement of the central nervous system pre-treatment, coexisting diseases and cerebrospinal fluid findings before treatment and during follow-up, were not long term HRQoL and fatigue.en
dc.language.isoengeng
dc.publisherJohn Wiley & Sons, Inc.eng
dc.relation.ispartof<a href="http://hdl.handle.net/1956/5870" target="blank">European neuroborreliosis: Long term follow-up</a>eng
dc.subjectfatigueeng
dc.subjectInflammationeng
dc.subjectLyme diseaseeng
dc.subjectLyme neuroborreliosiseng
dc.subjectPredictorseng
dc.subjectRisk factorseng
dc.subjectQuality of lifeeng
dc.titleRisk factors for a non-favourable outcome after treated European Neuroborreliosiseng
dc.typeJournal articleeng
dc.subject.nsiVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Neurology: 752eng
dc.rights.holderCopyright the author(s). Acta Neurologica Scandinavica Copyright 2012 John Wiley & Sons A/S
dc.type.versionsubmittedVersioneng
bora.cristinID1030470eng
bibo.doihttp://dx.doi.org/10.1111/j.1600-0404.2012.01690.xeng
dc.identifier.cristinID1030470eng
dc.identifier.doihttp://dx.doi.org/10.1111/j.1600-0404.2012.01690.x
dcterms.isPartOfhttp://hdl.handle.net/1956/5870


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