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Risk factors for a non-favourable outcome after treated European Neuroborreliosis

Bergen Open Research Archive

Show simple item record Eikeland, Randi eng Mygland, Åse eng Herlofson, Karen eng Ljøstad, Unn eng 2012-07-02T11:15:22Z 2012-07-02T11:15:22Z 2011
dc.identifier.citation Acta Neurologica Scandinavica en
dc.identifier.issn 0001-6314
dc.description.abstract Aim: To identify risk factors for a non-favourable long term outcome with respect to Health Related Quality of Life (HRQoL) and fatigue after treated Lyme Neuroborreliosis (LNB). Methods: We followed 50 LNB patients, and assessed outcome by the self-report questionnaires Short Form-36 (SF-36) and Fatigue Severity Scale (FSS) 30 months after treatment. We analyzed associations between these outcomes and demographical, clinical and laboratory data by univariate analyses and linear regression. Clinical status was assessed by a composite score based on subjective complaints and objective findings. Results: Pre-treatment symptom duration > 6 weeks (B=-10.2, P=0.002) and non-complete recovery at 12 months (B=-5.6, P=0.033) were associated with lower scores in the SF-36 domain Physical Component Summary (R2=0.59). Non-complete recovery at 4 months was associated with lower scores in the SF-36 domain Mental Component Summary (B=-8.9, P=0.01 (R2= 0.37)). Pre-treatment symptom duration > 6 weeks (B=1.3, P= 0.028), high scores on the composite clinical score pre-treatment (B=0.1, P=0.019) and non-complete recovery at 12 months (B=1.7, P=0.001) were associated with higher FSS scores (R2=0.70). No laboratory test results were associated with these outcomes. Conclusions: Delayed treatment start, more symptoms and findings before and non-complete recovery at 4 and 12 months after treatment seem to predict a non-favourable outcome regarding HRQoL and fatigue 30 months after treated LNB. Age, gender, educational level involvement of the central nervous system pre-treatment, coexisting diseases and cerebrospinal fluid findings before treatment and during follow-up, were not long term HRQoL and fatigue. en
dc.language.iso eng eng
dc.publisher John Wiley & Sons, Inc. en
dc.relation.ispartof <a href="" target="blank">European neuroborreliosis: Long term follow-up</a>
dc.rights Copyright the author(s). Acta Neurologica Scandinavica Copyright 2012 John Wiley & Sons A/S eng
dc.subject fatigue eng
dc.subject inflammation eng
dc.subject Lyme disease eng
dc.subject Lyme neuroborreliosis eng
dc.subject predictors eng
dc.subject risk factors eng
dc.subject quality of life eng
dc.title Risk factors for a non-favourable outcome after treated European Neuroborreliosis en
dc.type Journal article eng
dc.subject.nsi VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Neurology: 752 eng
dc.type.version submittedVersion eng
bora.cristinID 1030470
bibo.doi eng

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