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Risk factors for a non-favourable outcome after treated European Neuroborreliosis

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dc.contributor.author Eikeland, Randi
dc.contributor.author Mygland, Åse
dc.contributor.author Herlofson, Karen
dc.contributor.author Ljøstad, Unn
dc.date.accessioned 2012-07-02T11:15:22Z
dc.date.available 2012-07-02T11:15:22Z
dc.date.issued 2011
dc.identifier.citation Acta Neurologica Scandinavica en
dc.identifier.issn 0001-6314
dc.identifier.uri http://dx.doi.org/10.1111/j.1600-0404.2012.01690.x
dc.identifier.uri http://hdl.handle.net/1956/5869
dc.description.abstract Aim: To identify risk factors for a non-favourable long term outcome with respect to Health Related Quality of Life (HRQoL) and fatigue after treated Lyme Neuroborreliosis (LNB). Methods: We followed 50 LNB patients, and assessed outcome by the self-report questionnaires Short Form-36 (SF-36) and Fatigue Severity Scale (FSS) 30 months after treatment. We analyzed associations between these outcomes and demographical, clinical and laboratory data by univariate analyses and linear regression. Clinical status was assessed by a composite score based on subjective complaints and objective findings. Results: Pre-treatment symptom duration > 6 weeks (B=-10.2, P=0.002) and non-complete recovery at 12 months (B=-5.6, P=0.033) were associated with lower scores in the SF-36 domain Physical Component Summary (R2=0.59). Non-complete recovery at 4 months was associated with lower scores in the SF-36 domain Mental Component Summary (B=-8.9, P=0.01 (R2= 0.37)). Pre-treatment symptom duration > 6 weeks (B=1.3, P= 0.028), high scores on the composite clinical score pre-treatment (B=0.1, P=0.019) and non-complete recovery at 12 months (B=1.7, P=0.001) were associated with higher FSS scores (R2=0.70). No laboratory test results were associated with these outcomes. Conclusions: Delayed treatment start, more symptoms and findings before and non-complete recovery at 4 and 12 months after treatment seem to predict a non-favourable outcome regarding HRQoL and fatigue 30 months after treated LNB. Age, gender, educational level involvement of the central nervous system pre-treatment, coexisting diseases and cerebrospinal fluid findings before treatment and during follow-up, were not long term HRQoL and fatigue. en
dc.language.iso eng en
dc.publisher John Wiley & Sons, Inc. en
dc.relation.ispartof <a href="http://hdl.handle.net/1956/5870" target="blank">European neuroborreliosis: Long term follow-up</a>
dc.rights Copyright the author(s). Acta Neurologica Scandinavica Copyright 2012 John Wiley & Sons A/S en
dc.subject fatigue en
dc.subject inflammation en
dc.subject Lyme disease en
dc.subject Lyme neuroborreliosis en
dc.subject predictors en
dc.subject risk factors en
dc.subject quality of life en
dc.title Risk factors for a non-favourable outcome after treated European Neuroborreliosis en
dc.type Journal article en
dc.subject.nsi VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Neurology: 752 en
dc.type.version submittedVersion en
bora.cristinID 1030470


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