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Quantitative proteome profiling reveals molecular hallmarks of egg quality in Atlantic halibut: impairments of transcription and protein folding impede protein and energy homeostasis during early development
(Journal article; Peer reviewed, 2022)Background Tandem mass tag spectrometry (TMT labeling-LC-MS/MS) was utilized to examine the global proteomes of Atlantic halibut eggs at the 1-cell-stage post fertilization. Comparisons were made between eggs judged to ... -
Quantitative proteomic analyses of CD4+ and CD8+ T cells reveal differentially expressed proteins in multiple sclerosis patients and healthy controls
(Peer reviewed; Journal article, 2019-05-08)Background Multiple sclerosis (MS) is an autoimmune, neuroinflammatory disease, with an unclear etiology. However, T cells play a central role in the pathogenesis by crossing the blood–brain-barrier, leading to inflammation ... -
Quantitative proteomics comparison of arachnoid cyst fluid and cerebrospinal fluid collected perioperatively from arachnoid cyst patients
(Peer reviewed; Journal article, 2013-04-29)Background: There is little knowledge concerning the content and the mechanisms of filling of arachnoid cysts. The aim of this study was to compare the protein content of arachnoid cysts and cerebrospinal fluid by quantitative ... -
Quantitative proteomics reveals protein dysregulation during T cell activation in multiple sclerosis patients compared to healthy controls
(Journal article; Peer reviewed, 2022-07-05)Background: Multiple sclerosis (MS) is an autoimmune, neurodegenerative disorder with a strong genetic component that acts in a complex interaction with environmental factors for disease development. CD4+ T cells are pivotal ... -
Quantitative pupillometry in comatose out-of-hospital cardiac arrest patients: A post-hoc analysis of the TTH48 trial
(Journal article; Peer reviewed, 2022)Background: Quantitative pupillometry is an objective method to examine pupil reaction and subsequently grade the response on a neurological pupil index (NPi) scale from 0 to 5. The aim of the present sub-study was to ... -
Quantitative User Data From a Chatbot Developed for Women With Gestational Diabetes Mellitus: Observational Study
(Journal article; Peer reviewed, 2022)Background: The rising prevalence of gestational diabetes mellitus (GDM) calls for the use of innovative methods to inform and empower these pregnant women. An information chatbot, Dina, was developed for women with GDM ... -
The quaternary structure of human tyrosine hydroxylase: effects of dystonia‐associated missense variants on oligomeric state and enzyme activity
(Journal article; Peer reviewed, 2019)Tyrosine hydroxylase (TH) is a multi-domain, homo-oligomeric enzyme that catalyses the rate-limiting step of catecholamine neurotransmitter biosynthesis. Missense variants of human TH are associated with a recessive ... -
Queer challenges in maternity care. A qualitative study about lesbian couples’ experiences
(Doctoral thesis, 2015-03-20)The number of lesbian women opting for motherhood is increasing, implying that healthcare providers are likely to encounter lesbian couples in all maternity care contexts. Although an increasing proportion of the Norwegian ... -
Questioning the ethics of international research on formula milk supplementation in low-income African countries: response
(Journal article; Peer reviewed, 2022) -
Questions about complementary and alternative medicine to the Regional Medicines Information and Pharmacovigilance Centres in Norway (RELIS): a descriptive pilot study
(Peer reviewed; Journal article, 2014-02-14)Background: Provision of clinically relevant information about complementary and alternative medicine (CAM) to health care professionals is not well described. The aim of the study was to assess questions about CAM to the ... -
A question–answer pair (QAP) database integrated with websites to answer complex questions submitted to the Regional Medicines Information and Pharmacovigilance Centres in Norway (RELIS): a descriptive study
(Peer reviewed; Journal article, 2012-03-15)Objective To assess a question–answer pair (QAP) database integrated with websites developed for drug information centres to answer complex questions effectively. Design Descriptive study with comparison of two subsequent ... -
Quetiapine, Misuse and dependency: A case-series of questions to a Norwegian network of drug information centers
(Journal article; Peer reviewed, 2021)Purpose: The second-generation antipsychotic quetiapine has been associated with misuse and dependency. We aimed to review questions to the Norwegian network of drug information centers concerning this potential drug safety ... -
Race duration and blood pressure are major predictors of exercise-induced cardiac troponin elevation
(Peer reviewed; Journal article, 2019)Background: The underlying mechanisms of the exercise-induced increase in cardiac troponins (cTn) are poorly understood. The aim of this study was to identify independent determinants of exercise-induced cTn increase in a ... -
Radiation induced brain necrosis after proton therapy for head and neck cancer
(Doctoral thesis, 2022-12-09)Protonterapi gir reduksjon i normalvevsdoser sammenlignet med strålebehandling med fotoner, og det er antatt at dette vil resultere i en lavere forekomst av stråleinduserte seinskader. For å kompensere for en økt biologisk ... -
Radiofrequency ablation of atrial fibrillation. Clinical results and studies of mechanisms
(Doctoral thesis, 2011-09-30)Introduction: Atrial fibrillation (AF) is the most common form of sustained cardiac arrhythmia. AF requires a trigger that initiates the arrhythmia, and the presence of a predisposing substrate that perpetuates it. ... -
A radiogenomics application for prognostic profiling of endometrial cancer
(Journal article; Peer reviewed, 2021)Prognostication is critical for accurate diagnosis and tailored treatment in endometrial cancer (EC). We employed radiogenomics to integrate preoperative magnetic resonance imaging (MRI, n = 487 patients) with histologic-, ... -
Radiographic features in 2D imaging as predictors for justified CBCT examinations of canine-induced root resorption
(Journal article; Peer reviewed, 2022)Objectives: This retrospective observational study aimed to evaluate the diagnostic accuracy of two-dimensional radiographs on canine-induced root resorption (CIRR) in lateral incisors and identify predictors of CIRR in ... -
Radiographic imaging in relation to the mandibular third molar: a survey among oral surgeons in Sweden
(Journal article; Peer reviewed, 2022)Objectives To query the experience of oral surgeons concerning referral routines and preferences for radiographic imaging modality before surgical removal of mandibular third molars and investigate factors that influence ... -
Radiographic markers of hip dysplasia in young adults: predictive effect of factors in early life
(Journal article; Peer reviewed, 2023-02-11)Background and objectives: Acetabular dysplasia in young adults occurs, despite screening for developmental hip dysplasia (DDH) in the neonatal period. We aimed to examine how early life factors predict radiographic ...