Blar i Faculty of Medicine på emneord "Endometrial cancer"

Viser treff 1-13 av 13

    • Androgen receptor as potential therapeutic target in metastatic endometrial cancer 

      Tangen, Ingvild Løberg; Onyango, Therese Bredholt; Kopperud, Reidun Kristin; Berg, Anna; Halle, Mari Kyllesø; Øyan, Anne Margrete; Werner, Henrica Maria Johanna; Trovik, Jone; Kalland, Karl-Henning; Salvesen, Helga Birgitte; Krakstad, Camilla (Peer reviewed; Journal article, 2016-06-30)
      Purpose: The expression and involvement of estrogen (ER) and progesterone receptor (PR) is extensively studied in endometrial cancer. Androgen receptor (AR) is a hormone receptor less studied in female cancers, and we here ...

    • Aneuploidy related transcriptional changes in endometrial cancer link low expression of chromosome 15q genes to poor survival 

      Mauland, Karen Klepsland; Wik, Elisabeth; Høivik, Erling Andre; Kusonmano, Kanthida; Halle, Mari Kyllesø; Berg, Anna; Haugland, Hans Kristian; Øyan, Anne Margrete; Kalland, Karl-Henning; Stefansson, Ingunn Marie; Akslen, Lars A.; Krakstad, Camilla; Trovik, Jone; Werner, Henrica Maria Johanna; Salvesen, Helga Birgitte (Peer reviewed; Journal article, 2017)
      Aneuploidy is a widely studied prognostic marker in endometrial cancer (EC), however, not implemented in clinical decision-making. It lacks validation in large prospective patient cohorts adjusted for currently standard ...

    • Associations of pregnancy-related factors and birth characteristics with risk of endometrial cancer: A Nordic population-based case-control study 

      Trabert, Britton; Troisi, Rebecca; Grotmol, Tom; Ekbom, Anders; Engeland, Anders; Gissler, Mika; Glimelius, Ingrid; Madanat-Harjuoja, Laura M.; Sørensen, Henrik Toft; Tretli, Steinar; Ording, Anne Gulbech; Bjørge, Tone (Peer reviewed; Journal article, 2020)
      Many pregnancy‐related factors are associated with reduced endometrial cancer risk. However, it remains unclear whether pregnancy‐related complications (e.g., hypertensive conditions) are associated with risk and whether ...

    • Blood Metabolites Associate with Prognosis in Endometrial Cancer 

      Strand, Elin; Tangen, Ingvild Løberg; Fasmer, Kristine Eldevik; Jacob, Havjin; Halle, Mari Kyllesø; Hoivik, Erling A; Delvoux, Bert; Trovik, Jone; Haldorsen, Ingfrid S.; Romano, Andrea; Krakstad, Camilla (Peer reviewed; Journal article, 2019-12-14)
      Endometrial cancer has a high prevalence among post-menopausal women in developed countries. We aimed to explore whether certain metabolic patterns could be related to the characteristics of aggressive disease and poorer ...

    • Blood steroid levels predict survival in endometrial cancer and reflect tumor estrogen signaling 

      Forsse, David Erik; Tangen, Ingvild Løberg; Fasmer, Kristine Eldevik; Halle, Mari Kyllesø; Viste, Kristin; Almås, Bjørg; Bertelsen, Bjørn-Erik; Trovik, Jone; Haldorsen, Ingfrid S.; Krakstad, Camilla (Peer reviewed; Journal article, 2020-02)
      Objective Blood-based biomarkers are attractive due to ease of sampling and standardized measurement technology, reducing obstacles to clinical implementation. The objective of this study was to evaluate a clinically ...

    • DNA ploidy in curettage specimens identifies high-risk patients and lymph node metastasis in endometrial cancer 

      Njølstad, Tormund Salvesen; Trovik, Jone; Hveem, Tarjei Sveinsgjerd; Kjæreng, Marna Lill; Kildal, Wanja; Pradhan, Manohar; Marcickiewicz, Janusz; Tingulstad, Solveig; Staff, Anne Cathrine; Haugland, Hans Kristian; Eraker, Runar; Oddenes, Klaus; Rokne, Jan Anders; Tjugum, Jostein; Lode, Margaret Sævik; Amant, Frédéric; Werner, Henrica Maria Johanna; Salvesen, Helga Birgitte; Danielsen, Håvard Emil (Peer reviewed; Journal article, 2015-04-21)
      Background: Preoperative risk stratification is essential in tailoring endometrial cancer treatment, and biomarkers predicting lymph node metastasis and aggressive disease are aspired in clinical practice. DNA ploidy ...

    • High visceral fat percentage is associated with poor outcome in endometrial cancer 

      Mauland, Karen Klepsland; Eng, Øyvin Andre Solberg; Ytre-Hauge, Sigmund; Tangen, Ingvild Løberg; Berg, Anna; Salvesen, Helga; Salvesen, Øyvind; Krakstad, Camilla; Trovik, Jone; Høivik, Erling Andre; Werner, Henrica Maria Johanna; Mellgren, Gunnar; Haldorsen, Ingfrid S. (Peer reviewed; Journal article, 2017-10-19)
      Despite evidence of increased endometrial cancer (EC) risk in obese women, the impact of obesity on clinical and histological phenotype is poorly understood. This study explored abdominal fat volumes and fat distribution ...

    • Hormone receptor loss in endometrial carcinoma curettage predicts lymph node metastasis and poor outcome in prospective multicentre trial 

      Trovik, Jone; Wik, Elisabeth; Werner, Henrica Maria Johanna; Krakstad, Camilla; Helland, Harald; Vandenput, Ingrid; Njølstad, Tormund Salvesen; Stefansson, Ingunn; Marcickiewicz, Janusz; Tingulstad, Solveig; Staff, Anne Cathrine; Amant, Frédéric; Akslen, Lars A.; Salvesen, Helga Birgitte (Peer reviewed; Journal article, 2013-11)
      Background: Preoperative histologic examination of tumour tissue is essential when deciding if endometrial cancer surgery should include lymph node sampling. We wanted to investigate if biomarkers could improve prediction ...

    • Impact of body mass index and fat distribution on sex steroid levels in endometrial carcinoma: A retrospective study 

      van Weelden, Willem Jan; Fasmer, Kristine Eldevik; Tangen, Ingvild Løberg; IntHout, Joanna; Abbink, Karin; van Herwaarden, Antonius E.; Krakstad, Camilla; Massuger, Leon F.A.G.; Haldorsen, Ingfrid S.; Pijnenborg, Johanna M.A. (Peer reviewed; Journal article, 2019-06-07)
      Background Obesity is an important cause of multiple cancer types, amongst which endometrial cancer (EC). The relation between obesity and cancer is complicated and involves alterations in insulin metabolism, response to ...

    • KRAS gene amplification and overexpression but not mutation associates with aggressive and metastatic endometrial cancer 

      Birkeland, Even; Wik, Elisabeth; Mjøs, Siv; Høivik, Erling Andre; Trovik, Jone; Werner, Henrica Maria Johanna; Kusonmano, Kanthida; Petersen, Kjell; Ræder, Maria B.; Holst, Frederik; Øyan, Anne Margrete; Kalland, Karl-Henning; Akslen, Lars A.; Simon, Ronald; Krakstad, Camilla; Salvesen, Helga Birgitte (Peer reviewed; Journal article, 2012)
      BACKGROUND: Three quarter of endometrial carcinomas are treated at early stage. Still, 15 to 20% of these patients experience recurrence, with little effect from systemic therapies. Homo sapiens v-Ki-ras2 Kirsten rat sarcoma ...

    • MDM2 promoter polymorphism del1518 (rs3730485) and its impact on endometrial and ovarian cancer risk 

      Gansmo, Liv Beathe; Bjørnslett, Merete Pauline; Halle, Mari Kyllesø; Salvesen, Helga; Romundstad, Pål Richard; Hveem, Kristian; Vatten, Lars Johan; Dørum, Anne; Lønning, Per Eystein; Knappskog, Stian (Peer reviewed; Journal article, 2017-02-03)
      Background: The del1518 (rs3730485) polymorphism is an in/del variant in the MDM2 promoter P1. The variant is in complete linkage disequilibrium with MDM2 SNP309 (rs2279744) and has previously been found associated with ...

    • The MDM4 SNP34091 (rs4245739) C-allele is associated with increased risk of ovarian—but not endometrial cancer 

      Gansmo, Liv Beathe; Bjørnslett, Merete Pauline; Halle, Mari Kyllesø; Salvesen, Helga Birgitte; Dørum, Anne; Birkeland, Einar Elvbakken; Hveem, Kristian; Romundstad, Pål Richard; Vatten, Lars Johan; Lønning, Per Eystein; Knappskog, Stian (Peer reviewed; Journal article, 2016-02-11)
      The MDM4 protein (also known as MDMX or HDMX) is a negative regulator of p53, not only by direct interaction but also through its interaction with MDM2. Further, MDM4 overexpression and amplification have been observed in ...

    • What is the best preoperative imaging for endometrial cancer? 

      Haldorsen, Ingfrid S.; Salvesen, Helga (Peer reviewed; Journal article, 2016-04)
      Although endometrial cancer is surgicopathologically staged, preoperative imaging is recommended for diagnostic work-up to tailor surgery and adjuvant treatment. For preoperative staging, imaging by transvaginal ultrasound ...