Browsing Faculty of Medicine by Author "Hardie, Jon Andrew"
Now showing items 1-14 of 14
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Airway obstruction, dynamic hyperinflation, and breathing pattern during incremental exercise in COPD patients
Frisk, Bente; Espehaug, Birgitte; Hardie, Jon Andrew; Strand, Liv Inger; Moe-Nilssen, Rolf; Eagan, Tomas Mikal; Bakke, Per; Thorsen, Einar (Peer reviewed; Journal article, 2014-02-01)Ventilatory capacity is reduced in chronic obstructive pulmonary disease (COPD) patients. Tidal volume (VT) is lower and breathing frequency higher at a given ventilation (VE) compared to healthy subjects. We examined ... -
Alcohol at bedtime induces minor changes in sleep stages and blood gases in stable chronic obstructive pulmonary disease
Holmedahl, Nils Henrik; Øverland, Britt; Fondenes, Ove; Ellingsen, Ivar; Hardie, Jon Andrew (Peer reviewed; Journal article, 2014-05-17)Purpose/background: The purpose of this study is to explore the effect of a moderate dose of alcohol on sleep architecture and respiration in chronic obstructive pulmonary disease (COPD). Alcohol depresses both hypercapnic ... -
The association of tidal EFL with exercise performance, exacerbations, and death in COPD
Aarli, Bernt Bøgvald; Calverley, Peter M.A.; Jensen, Robert L.; Dellacà, Raffaele; Eagan, Tomas Mikal; Bakke, Per S.; Hardie, Jon Andrew (Peer reviewed; Journal article, 2017-07-26)Background: Tidal expiratory flow limitation (EFLT) is frequently found in patients with COPD and can be detected by forced oscillations when within-breath reactance of a single-breath is ≥0.28 kPa·s·L-1. The present study ... -
Chronic Obstructive Pulmonary Disease Is Associated with Low Levels of Vitamin D
Persson, Louise Jeanette Pauline; Aanerud, Marianne; Hiemstra, Pieter Sicco; Hardie, Jon Andrew; Bakke, Per; Eagan, Tomas Mikal (Peer reviewed; Journal article, 2012-06-21)Introduction: COPD patients may be at increased risk for vitamin D (25(OH)D) deficiency, but risk factors for deficiency among COPD patients have not been extensively reported. Methods: Serum 25(OH)D levels were measured ... -
CT-defined emphysema in COPD patients and risk for change in desaturation status in 6-min walk test
Wåtevik, Marie; Frisk, Bente; Real, Francisco Gomez; Hardie, Jon Andrew; Bakke, Per; Eagan, Tomas Mikal Lind; Johannessen, Ane (Journal article; Peer reviewed, 2021)Background Emphysema and exercise induced desaturation (EID) are both related to poorer COPD prognosis. More knowledge of associations between emphysema and desaturation is needed for more efficient disease management. ... -
Lung hyperinflation and functional exercise capacity in patients with COPD - a three-year longitudinal study
Aalstad, Linn T.; Hardie, Jon Andrew; Espehaug, Birgitte; Thorsen, Einar; Bakke, Per S.; Eagan, Tomas Mikal; Frisk, Bente (Peer reviewed; Journal article, 2018-12-06)Background: Lung hyperinflation contributes to dyspnea, morbidity and mortality in chronic obstructive pulmonary disease (COPD). The inspiratory-to-total lung capacity (IC/TLC) ratio is a measure of lung hyperinflation and ... -
Peak oxygen uptake and breathing pattern in COPD patients – a four-year longitudinal study
Frisk, Bente; Hardie, Jon Andrew; Espehaug, Birgitte; Strand, Liv Inger; Moe-Nilssen, Rolf; Eagan, Tomas Mikal; Bakke, Per; Thorsen, Einar (Peer reviewed; Journal article, 2015-08-19)Background: Activities of daily living in patients with chronic obstructive pulmonary disease (COPD) are limited by exertional dyspnea and reduced exercise capacity. The aims of the study were to examine longitudinal changes ... -
Predictors of diagnostic yield in bronchoscopy: a retrospective cohort study comparing different combinations of sampling techniques
Roth, Kjetil; Hardie, Jon Andrew; Andreassen, Alf H.; Leh, Friedemann; Eagan, Tomas Mikal (Peer reviewed; Journal article, 2008-01-26)Background: The reported diagnostic yield from bronchoscopies in patients with lung cancer varies greatly. The optimal combination of sampling techniques has not been finally established. The objectives of this study were ... -
Predictors of exacerbations in chronic obstructive pulmonary disease - results from the Bergen COPD Cohort Study
Husebø, Gunnar Reksten; Bakke, Per; Aanerud, Marianne; Hardie, Jon Andrew; Ueland, Thor; Grønseth, Rune; Persson, Louise Jeanette Pauline; Aukrust, Pål; Eagan, Tomas Mikal (Peer reviewed; Journal article, 2014-10-03)Background: COPD exacerbations accelerate disease progression. Aims To examine if COPD characteristics and systemic inflammatory markers predict the risk for acute COPD exacerbation (AECOPD) frequency and duration. Methods: ... -
Prevalence and prognostic ability of the GOLD 2017 classification compared to the GOLD 2011 classification in a Norwegian COPD cohort
Le, Lan Ai Kieu; Johannessen, Ane; Hardie, Jon Andrew; Johansen, Odd Erik; Gulsvik, Amund; Vikse, Bjørn Egil; Bakke, Per S. (Peer reviewed; Journal article, 2019-07-23)Rationale: The Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2017 is based on an ABCD assessment tool of symptoms and exacerbation history and grade 1–4 of airflow limitation severity, facilitating ... -
Risk factors for lung cancer in COPD - results from the Bergen COPD cohort study
Husebø, Gunnar Reksten; Nielsen, Rune; Hardie, Jon Andrew; Bakke, Per S.; Lerner, Lorena; D'Alessandro-Gabazza, Corina; Gyuris, Jeno; Gabazza, Esteban; Aukrust, Pål; Eagan, Tomas Mikal (Peer reviewed; Journal article, 2019)Background: COPD patients have an increased risk of developing lung cancer, but the underlying mechanisms are poorly understood. We aimed to identify risk factors for lung cancer in patients from the Bergen COPD Cohort ... -
Sleep hypoventilation and daytime hypercapnia in stable chronic obstructive pulmonary disease
Holmedahl, Nils Henrik; Øverland, Britt; Fondenes, Ove; Ellingsen, Ivar; Hardie, Jon Andrew (Peer reviewed; Journal article, 2014-02-27)Purpose: To explore the associations between sleep hypoventilation (SH) and daytime arterial pressures of carbon dioxide (PaCO2), sleep stages, and sleep apneas/hypopneas (AHI) in subjects with chronic obstructive pulmonary ... -
TNF-α is associated with loss of lean body mass only in already cachectic COPD patients
Eagan, Tomas Mikal; Gabazza, Esteban C.; D’Alessandro-Gabazza, Corina; Gil-Bernabe, Paloma; Aoki, Shinya; Hardie, Jon Andrew; Bakke, Per; Wagner, Peter D. (Peer reviewed; Journal article, 2012-06-18) -
Vitamin D, vitamin D binding protein, and longitudinal outcomes in COPD
Persson, Louise Jeanette Pauline; Aanerud, Marianne; Hiemstra, Pieter Sicco; Michelsen, Annika; Ueland, Thor; Hardie, Jon Andrew; Aukrust, Pål; Bakke, Per S.; Eagan, Tomas Mikal (Peer reviewed; Journal article, 2015-03-24)Background: Associations between Vitamin D3 [25(OH)D], vitamin D binding protein (VDBP) and chronic obstructive pulmonary disease (COPD) are previously reported. We aimed to further investigate these associations on ...