Blar i Faculty of Medicine på forfatter "Nepstad, Ina"
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Characterisation and expression analysis of the Atlantic halibut (Hippoglossus hippoglossus L.) cytokines: IL-1β, IL-6, IL-11, IL-12β and IFNγ
Øvergård, Aina-Cathrine; Nepstad, Ina; Nerland, Audun Helge; Patel, Sonal (Peer reviewed; Journal article, 2011-06-05)Genes encoding the five Atlantic halibut (Hippoglossus hippoglossus L.) cytokines; interleukin (IL)-1b, IL-6, IL-11b, IL-12bc, and interferon (IFN) c, were cloned and characterised at a molecular level. The genomic ... -
Clonal heterogeneity reflected by pi3k-akt-mtor signaling in human acute myeloid leukemia cells and its association with adverse prognosis
Nepstad, Ina; Hatfield, Kimberley Joanne; Tvedt, Tor Henrik Anderson; Reikvam, Håkon; Bruserud, Øystein (Peer reviewed; Journal article, 2018-09-14)Clonal heterogeneity detected by karyotyping is a biomarker associated with adverse prognosis in acute myeloid leukemia (AML). Constitutive activation of the phosphatidylinositol-3-kinase-Akt-mechanistic target of rapamycin ... -
Cytokines, adhesion molecules, and matrix metalloproteases as predisposing, diagnostic, and prognostic factors in venous thrombosis
Mosevoll, Knut Anders; Johansen, Silje; Wendelbo, Øystein; Nepstad, Ina; Bruserud, Øystein; Reikvam, Håkon (Peer reviewed; Journal article, 2018-05-22)The inflammatory response is a well-established part of, and a prerequisite for, venous thrombosis. To better understand the pathophysiology of venous thrombosis and to identify improved diagnostic biomarkers, further ... -
Mesenchymal stem cells support survival and proliferation of primary human acute myeloid leukemia cells through heterogeneous molecular mechanisms
Brenner, Annette; Nepstad, Ina; Bruserud, Øystein (Peer reviewed; Journal article, 2017-02-09)Acute myeloid leukemia (AML) is a bone marrow malignancy, and various bone marrow stromal cells seem to support leukemogenesis, including osteoblasts and endothelial cells. We have investigated how normal bone marrow ... -
The PI3K-Akt-mTOR intracellular signaling pathway in human acute myeloid leukemia
Nepstad, Ina (Doctoral thesis, 2019-03-08)Acute myeloid leukemia (AML) is a heterogeneous malignancy where disruption of normal intracellular signaling occurs due to mutations or abnormal external signaling. Many pathways have emerged as potential targets for ... -
The PI3K-Akt-mTOR signaling pathway in human acute myeloid leukemia (AML) cells
Nepstad, Ina; Hatfield, Kimberley Joanne; Grønningsæter, Ida Sofie; Reikvam, Håkon (Journal article; Peer reviewed, 2020)Acute myeloid leukemia (AML) is a heterogeneous group of diseases characterized by uncontrolled proliferation of hematopoietic stem cells in the bone marrow. Malignant cell growth is characterized by disruption of normal ... -
Resistance to the antiproliferative in vitro effect of PI3K-Akt-mTOR inhibition in primary human acute myeloid leukemia cells is associated with altered cell metabolism
Nepstad, Ina; Reikvam, Håkon; Brenner, Annette; Bruserud, Øystein; Hatfield, Kimberley Joanne (Peer reviewed; Journal article, 2018-01-27)Constitutive signaling through the phosphatidylinositol-3-kinase-Akt-mechanistic target of rapamycin (PI3K-Akt-mTOR) pathway is present in acute myeloid leukemia (AML) cells. However, AML is a heterogeneous disease, and ...