• Neopterin and kynurenic acid as predictors of stroke recurrence and mortality: a multicentre prospective cohort study on biomarkers of infammation measured three months after ischemic stroke 

      Alme, Katinka Nordheim; Ulvik, Arve; Askim, Torunn; Assmus, Jörg; Mollnes, Tom Eirik; Naik, Mala; Næss, Halvor; Saltvedt, Ingvild; Ueland, Per-Magne; Knapskog, Anne Brita (Journal article; Peer reviewed, 2021)
      Background Chronic low-grade inflammation is associated with both ischemic stroke and sedentary behaviour. The aim of this study was to investigate the predictive abilities of biomarkers of inflammation and immune modulation ...
    • NOR-SASS (Norwegian Sonothrombolysis in Acute Stroke Study): Randomized controlled contrast-enhanced sonothrombolysis in an unselected acute ischemic stroke population 

      Nacu, Aliona; Kvistad, Christopher Elnan; Næss, Halvor; Øygarden, Halvor; Logallo, Nicola; Assmus, Jörg; Waje-Andreassen, Ulrike; Kurz, Kathinka Dæhli; Neckelmann, Gesche F; Thomassen, Lars (Peer reviewed; Journal article, 2016-02)
      Background and Purpose—The NOR-SASS (Norwegian Sonothrombolysis in Acute Stroke Study) aimed to assess effect and safety of contrast-enhanced ultrasound treatment in an unselected acute ischemic stroke population. ...
    • The Norwegian Cognitive impairment after stroke study (Nor-COAST): study protocol of a multicentre, prospective cohort study 

      Thingstad, Pernille; Askim, Torunn; Beyer, Mona K.; Bråthen, Geir; Ellekjær, Hanne; Ihle-Hansen, Hege; Knapskog, Anne Brita; Lydersen, Stian; Munthe-Kaas, Ragnhild; Næss, Halvor; Pendlebury, Sarah; Seljeseth, Yngve Müller; Saltvedt, Ingvild (Peer reviewed; Journal article, 2018-11-26)
      Background: Early and late onset post-stroke cognitive impairment (PCI) contributes substantially to disability following stroke, and is a high priority within stroke research. The aetiology for PCI is complex and related ...
    • The Norwegian Stroke in the Young Study (NOR-SYS): rationale and design 

      Fromm, Annette; Thomassen, Lars; Næss, Halvor; Meijer, Rudy; Eide, Geir Egil; Kråkenes, Jostein; Vedeler, Christian A.; Gerdts, Eva; Larsen, Terje H.; Kuiper, Karel Kier-Jan; Laxdal, Elin Hanna; Russell, David; Tatlisumak, Turgut; Waje-Andreassen, Ulrike (Peer reviewed; Journal article, 2013-07-17)
      Background: Ischemic stroke in young adults is a major health problem being associated with a higher vascular morbidity and mortality compared to controls, and a stroke recurrence rate of 25% during the first decade. The ...
    • The Norwegian tenecteplase stroke trial (NOR-TEST): randomised controlled trial of tenecteplase vs. alteplase in acute ischaemic stroke 

      Logallo, Nicola; Kvistad, Christopher Elnan; Nacu, Aliona; Næss, Halvor; Waje-Andreassen, Ulrike; Asmuss, Jörg; Aamodt, Anne Hege; Lund, Christian; Kurz, Martin; Rønning, Ole Morten; Salvesen, Rolf; Idicula, Titto T.; Thomassen, Lars (Peer reviewed; Journal article, 2014-05-15)
      Background: Alteplase is the only approved thrombolytic agent for acute ischaemic stroke. The overall benefit from alteplase is substantial, but some evidence indicates that alteplase also has negative effects on the ...
    • Olfactory dysfunction in chronic stroke patients 

      Wehling, Eike; Næss, Halvor; Wollschlaeger, Daniel; Hofstad, Håkon; Bramerson, Annika; Bende, Mats; Nordin, Steven (Peer reviewed; Journal article, 2015-10-12)
      Background The aim of the study was to investigate odor identification performance in patients one year after hospital admittance due to stroke. Predictors for olfactory dysfunction were investigated as well as self-reported ...
    • One-year versus five-year hospital readmission after ischemic stroke and TIA 

      Bjerkreim, Anna Therese; Næss, Halvor; Khanevski, Andrej; Thomassen, Lars; Waje-Andreassen, Ulrike; Logallo, Nicola (Peer reviewed; Journal article, 2019-01-29)
      Background: The burden of hospital readmission after stroke is substantial, but little knowledge exists on factors associated with long-term readmission after stroke. In a cohort comprising patients with ischemic stroke ...
    • Plasma Inflammatory Biomarkers Are Associated With Poststroke Cognitive Impairment: The Nor-COAST Study 

      Sandvig, Heidi Vihovde; Aam, Stina; Alme, Katinka Nordheim; Askim, Torunn; Beyer, Mona K.; Ellekjær, Hanne; Ihle-Hansen, Hege Beathe; Lydersen, Stian; Mollnes, Tom Eirik; Munthe-Kaas, Ragnhild; Næss, Halvor; Saltvedt, Ingvild Tina; Seljeseth, Yngve Müller; Thingstad, Anne Pernille Mæhle; Wethal, Torgeir; Knapskog, Anne Brita (Journal article; Peer reviewed, 2023)
      Background: Inflammation is proposed to be involved in the pathogenesis of poststroke cognitive impairment. The aim of this study was to investigate associations between concentrations of systemic inflammatory biomarkers ...
    • A pragmatic approach to sonothrombolysis in acute ischaemic stroke: The Norwegian randomised controlled sonothrombolysis in acute stroke study (NOR-SASS) 

      Nacu, Aliona; Kvistad, Christopher Elnan; Logallo, Nicola; Næss, Halvor; Waje-Andreassen, Ulrike; Aamodt, Anne Hege; Solhoff, Ragnar; Lund, Christian; Tobro, Håkon; Rønning, Ole Morten; Salvesen, Rolf; Idicula, Titto; Thomassen, Lars (Peer reviewed; Journal article, 2015-07-11)
      Background: Ultrasound accelerates thrombolysis with tPA (sonothrombolysis). Ultrasound in the absence of tPA also accelerates clot break-up (sonolysis). Adding intravenous gaseous microbubbles may potentiate the effect ...
    • Pre-stroke cognitive impairment is associated with vascular imaging pathology: a prospective observational study 

      Schellhorn, Till; Zucknick, Manuela; Askim, Torunn; Munthe-Kaas, Ragnhild; Ihle-Hansen, Hege; Seljeseth, Yngve Müller; Knapskog, Anne Brita; Næss, Halvor; Ellekjær, Hanne; Thingstad, Pernille; Wyller, Torgeir Bruun; Saltvedt, Ingvild; Beyer, Mona Kristiansen (Journal article; Peer reviewed, 2021)
      Background Chronic brain pathology and pre-stroke cognitive impairment (PCI) is predictive of post-stroke dementia. The aim of the current study was to measure pre-stroke neurodegenerative and vascular disease burden found ...
    • Prevalence of atherosclerosis and association with 5-year outcome: The Norwegian Stroke in the Young Study 

      Nawaz, Beenish; Fromm, Annette; Øygarden, Halvor; Eide, Geir E; Saeed, Sahrai; Meijer, Rudy; Bots, Michiel L; Sand, Kristin M; Thomassen, Lars; Næss, Halvor; Waje-Andreassen, Ulrike (Journal article; Peer reviewed, 2021)
      Objectives: We studied the prevalence of atherosclerosis among ischaemic stroke patients ≤60 years and controls at the time of the index stroke, and its association with occurrence of new cardiovascular events (CVEs) and ...
    • Recurrent ischemic stroke: Incidence, predictors, and impact on mortality 

      Khanevski, Andrej; Bjerkreim, Anna Therese; Novotny, Vojtech; Næss, Halvor; Thomassen, Lars; Logallo, Nicola; Kvistad, Christopher Elnan (Peer reviewed; Journal article, 2019)
      Background and purpose: Recurrent ischemic stroke (IS) or TIA is frequent with a considerable variation in incidence and mortality across populations. Current data on stroke recurrence and mortality are useful to examine ...
    • Risk factors and their impact on carotid intima-media thickness in young and middle-aged ischemic stroke patients and controls: The Norwegian Stroke in the Young Study 

      Fromm, Annette; Haaland, Øystein Ariansen; Næss, Halvor; Thomassen, Lars; Waje-Andreassen, Ulrike (Peer reviewed; Journal article, 2014-03-26)
      Background: Vascular morbidity and mortality due to cardiovascular disease (CVD) are high after ischemic stroke at a young age. Data on carotid intima-media thickness (cIMT) as marker of atherosclerosis are scarce for young ...
    • Serum uri acid: neuroprotection in thrombolysis. The Bergen NORSTROKE study 

      Logallo, Nicola; Næss, Halvor; Idicula, Titto T.; Brøgger, Jan C.; Waje-Andreassen, Ulrike; Thomassen, Lars (Peer reviewed; Journal article, 2011-09-25)
      Background: A possible synergic role of serum uric acid (SUA) with thrombolytic therapies is controversial and needs further investigations. We therefore evaluated association of admission SUA with clinical improvement and ...
    • Stroke patients’ knowledge about cardiovascular family history – the Norwegian Stroke in the Young Study (NOR-SYS). 

      Øygarden, Halvor; Fromm, Annette; Sand, Kristin Modalsli; Eide, Geir Egil; Thomassen, Lars; Næss, Halvor; Waje-Andreassen, Ulrike (Peer reviewed; Journal article, 2015-03-12)
      Background: Family history (FH) is a risk factor for cardiovascular disease, especially coronary artery disease (CAD). The impact on risk of stroke is less clear. This study investigated young and middle-aged ischemic ...
    • Stroke unit demand in Norway – present and future estimates 

      Dahl, Fredrik Andreas; Barra, Mathias; Faiz, Kashif Waqar; Ihle-Hansen, Hege; Næss, Halvor; Rand, Kim; Rønning, Ole Morten; Simonsen, Tone Breines; Thommessen, Bente; Labberton, Angela Susan (Journal article; Peer reviewed, 2022-03-15)
      Background: All stroke patients should receive timely admission to a stroke unit (SU). Consequently, most patients with suspected strokes – including stroke mimics (SM) are admitted. The aim of this study was to estimate ...
    • Tenecteplase, 0.4 mg/kg, in Moderate and Severe Acute Ischemic Stroke: A Pooled Analysis of NOR-TEST and NOR-TEST 2A 

      Novotny, Vojtech; Kvistad, Christopher Elnan; Næss, Halvor; Logallo, Nicola; Fromm, Annette; Khanevski, Andrej; Thomassen, Lars (Journal article; Peer reviewed, 2023)
      Background: The optimal dose of tenecteplase in acute ischemic stroke remains to be defined. We present a pooled analysis of the 2 NOR‐TESTs (Norwegian Tenecteplase Stroke Trials) exploring the efficacy and safety of ...
    • Vascular risk factor control and adherence to secondary preventive medication after ischaemic stroke 

      Gynnild, Mari Nordbø; Aakerøy, Rachel; Spigset, Olav; Askim, Torunn; Beyer, Mona Kristiansen; Ihle-Hansen, Hege; Munthe-Kaas, Ragnhild; Knapskog, Anne Brita; Lydersen, Stian; Næss, Halvor; Røsstad, Tove Garåsen; Seljeseth, Yngve Müller; Thingstad, Pernille; Saltvedt, Ingvild; Ellekjær, Hanne (Journal article; Peer reviewed, 2021)
      Background Studies regarding adequacy of secondary stroke prevention are limited. We report medication adherence, risk factor control and factors influencing vascular risk profile following ischaemic stroke. Methods A ...
    • Vascular risk factors and staging of atherosclerosis in patients and controls: The Norwegian Stroke in the Young Study 

      Nawaz, Beenish; Fromm, Annette; Øygarden, Halvor; Eide, Geir Egil; Saeed, Sahrai; Meijer, Rudy; Bots, Michiel L; Sand, Kristin Modalsli; Thomassen, Lars; Næss, Halvor; Waje-Andreassen, Ulrike (Journal article; Peer reviewed, 2022)
      Objectives: We studied the prevalence of vascular risk factors (RFs) among 385 ischaemic stroke patients ⩽60 years and 260 controls, and their association with atherosclerosis in seven vascular areas. Methods: History ...
    • Young ischaemic stroke incidence and demographic characteristics - The Norwegian stroke in the young study - A three-generation research program 

      Nawaz, Beenish; Eide, Geir Egil; Fromm, Annette; Øygarden, Halvor; Sand, Kristin Modalsli; Thomassen, Lars; Næss, Halvor; Waje-Andreassen, Ulrike (Journal article; Peer reviewed, 2019)
      Introduction: Norwegian Stroke in the Young Study (NOR-SYS) is a three-generation research program of young ischaemic stroke. In this study, we assessed ischaemic stroke incidence, education and work status among young ...